scholarly journals Editorial: Omics Data Integration Towards Mining of Phenotype Specific Biomarkers in Cancers and Diseases

2021 ◽  
Vol 9 ◽  
Author(s):  
Liang Cheng ◽  
Lei Deng ◽  
Chuan-Xing Li ◽  
Yan Zhang
Keyword(s):  
Data Integration ◽  
Omics Data ◽  
Omics Data Integration

scholarly journals Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer

2021 ◽  
Author(s):  
Kevin Chappell ◽  
Kanishka Manna ◽  
Charity L. Washam ◽  
Stefan Graw ◽  
Duah Alkam ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Data Integration ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Biological Pathways ◽  
Omics Data ◽  
Insight Into ◽  
Omics Data Integration

Multi-omics data integration of triple negative breast cancer (TNBC) provides insight into biological pathways.

scholarly journals MuSA: a graphical user interface for multi-OMICs data integration in radiogenomic studies

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mario Zanfardino ◽  
Rossana Castaldo ◽  
Katia Pane ◽  
Ornella Affinito ◽  
Marco Aiello ◽  
...  
Keyword(s):  
User Interface ◽  
Data Integration ◽  
Graphical User Interface ◽  
Data Science ◽  
Heterogeneous Data ◽  
Biological Information ◽  
Omics Data ◽  
Correlation Clustering ◽  
Downstream Analysis ◽  
Omics Data Integration

AbstractAnalysis of large-scale omics data along with biomedical images has gaining a huge interest in predicting phenotypic conditions towards personalized medicine. Multiple layers of investigations such as genomics, transcriptomics and proteomics, have led to high dimensionality and heterogeneity of data. Multi-omics data integration can provide meaningful contribution to early diagnosis and an accurate estimate of prognosis and treatment in cancer. Some multi-layer data structures have been developed to integrate multi-omics biological information, but none of these has been developed and evaluated to include radiomic data. We proposed to use MultiAssayExperiment (MAE) as an integrated data structure to combine multi-omics data facilitating the exploration of heterogeneous data. We improved the usability of the MAE, developing a Multi-omics Statistical Approaches (MuSA) tool that uses a Shiny graphical user interface, able to simplify the management and the analysis of radiogenomic datasets. The capabilities of MuSA were shown using public breast cancer datasets from TCGA-TCIA databases. MuSA architecture is modular and can be divided in Pre-processing and Downstream analysis. The pre-processing section allows data filtering and normalization. The downstream analysis section contains modules for data science such as correlation, clustering (i.e., heatmap) and feature selection methods. The results are dynamically shown in MuSA. MuSA tool provides an easy-to-use way to create, manage and analyze radiogenomic data. The application is specifically designed to guide no-programmer researchers through different computational steps. Integration analysis is implemented in a modular structure, making MuSA an easily expansible open-source software.

Multilevel heterogeneous omics data integration with kernel fusion

2018 ◽  
Author(s):  
Haitao Yang ◽  
Hongyan Cao ◽  
Tao He ◽  
Tong Wang ◽  
Yuehua Cui
Keyword(s):  
Data Integration ◽  
Omics Data ◽  
Kernel Fusion ◽  
Omics Data Integration

scholarly journals Application of multi-omics data integration and machine learning approaches to identify epigenetic and transcriptomic differences between in vitro and in vivo produced bovine embryos

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0252096
Author(s):  
Maria B. Rabaglino ◽  
Alan O’Doherty ◽  
Jan Bojsen-Møller Secher ◽  
Patrick Lonergan ◽  
Poul Hyttel ◽  
...  
Keyword(s):  
Machine Learning ◽  
Data Integration ◽  
Focal Adhesion ◽  
Learning Approach ◽  
Omics Data ◽  
Machine Learning Approach ◽  
Cluster 2 ◽  
Omics Data Integration

Pregnancy rates for in vitro produced (IVP) embryos are usually lower than for embryos produced in vivo after ovarian superovulation (MOET). This is potentially due to alterations in their trophectoderm (TE), the outermost layer in physical contact with the maternal endometrium. The main objective was to apply a multi-omics data integration approach to identify both temporally differentially expressed and differentially methylated genes (DEG and DMG), between IVP and MOET embryos, that could impact TE function. To start, four and five published transcriptomic and epigenomic datasets, respectively, were processed for data integration. Second, DEG from day 7 to days 13 and 16 and DMG from day 7 to day 17 were determined in the TE from IVP vs. MOET embryos. Third, genes that were both DE and DM were subjected to hierarchical clustering and functional enrichment analysis. Finally, findings were validated through a machine learning approach with two additional datasets from day 15 embryos. There were 1535 DEG and 6360 DMG, with 490 overlapped genes, whose expression profiles at days 13 and 16 resulted in three main clusters. Cluster 1 (188) and Cluster 2 (191) genes were down-regulated at day 13 or day 16, respectively, while Cluster 3 genes (111) were up-regulated at both days, in IVP embryos compared to MOET embryos. The top enriched terms were the KEGG pathway "focal adhesion" in Cluster 1 (FDR = 0.003), and the cellular component: "extracellular exosome" in Cluster 2 (FDR<0.0001), also enriched in Cluster 1 (FDR = 0.04). According to the machine learning approach, genes in Cluster 1 showed a similar expression pattern between IVP and less developed (short) MOET conceptuses; and between MOET and DKK1-treated (advanced) IVP conceptuses. In conclusion, these results suggest that early conceptuses derived from IVP embryos exhibit epigenomic and transcriptomic changes that later affect its elongation and focal adhesion, impairing post-transfer survival.

Sign in / Sign up

Export Citation Format

Share Document