Empreendedorismo Social em contexto Public - Descrição Bibliométrica com suporte em 76 anos de Investigações Indexadas na Web of Science

A pesquisa objetiva compreender o campo científico do tema Empreendedorismo Social a partir de pesquisas que abordam o campo de públicas. Após levantamento de 157 artigos indexados na base Web of Science, de 1945 a 2021, utilizando-se da palavra “social entrepreneurship”, no título, e “public”, em todos os campos, os dados foram inseridos no software VOSviewer para a construção dos mapas bibliométricos. Os resultados em relação às redes de (i) co-corrência de palavras-chave, que definiu: cluster 1 agrupou as palavras “field”, “innovation”, “legitimacy”, “organizations”, e “performance”; o cluster 2 que reuniu as palavras “challenges”, “management”, “perspective” e “social innovation”; o cluster 3, uniu as palavras “entrepreneurship”, “social economy”, “social enterprise” e “social entrepreseurship”; cluster 4 com as palavras “context”, “enterprise”, “impact” e “work”; cluster 5 “business”, “responsibility” e “susteainability”. Em relação à rede de (ii) co-citação por artigo, têm-se o cluster 1, com os autores Agafonow (2014), Bacq (2011), Fowler (2000), o cluster 2, com Baron (2007), Hoogendoorn (2016), Short (2009), o cluster 3, com Bacq (2018), Desa (2013) e o cluster 4, representado por Cook (2003), Karosec (2006). Outras três análises evidenciam um campo de estudo atrelado às questões críticas da sociedade, como crises socioambientais.

Prognostic Impact of An Integrative Landscape of Clinical, Immune, and Molecular Features in Non-Metastatic Rectal Cancer

Rectal Cancer (RC) is a complex disease that involves highly variable treatment responses. Currently, there is a lack of reliable markers beyond TNM to deliver a personalized treatment in a cancer setting where the goal is a curative treatment. Here, we performed an integrated characterization of the predictive and prognostic role of clinical features, mismatch-repair deficiency markers, HER2, CDX2, PD-L1 expression, and CD3−CD8+ tumor-infiltrating lymphocytes (TILs) coupled with targeted DNA sequencing of 76 non-metastatic RC patients assigned to total mesorectal excision upfront (TME; n = 15) or neoadjuvant chemo-radiotherapy treatment (nCRT; n = 61) followed by TME. Eighty-two percent of RC cases displayed mutations affecting cancer driver genes such as TP53, APC, KRAS, ATM, and PIK3CA. Good response to nCRT treatment was observed in approximately 40% of the RC cases, and poor pathological tumor regression was significantly associated with worse disease-free survival (DFS, HR = 3.45; 95%CI = 1.14–10.4; p = 0.028). High neutrophils-platelets score (NPS) (OR = 10.52; 95%CI=1.34–82.6; p = 0.025) and KRAS mutated cases (OR = 5.49; 95%CI = 1.06–28.4; p = 0.042) were identified as independent predictive factors of poor response to nCRT treatment in a multivariate analysis. Furthermore, a Cox proportional-hazard model showed that the KRAS mutational status was an independent prognostic factor associated with higher risk of local recurrence (HR = 9.68; 95%CI = 1.01–93.2; p <0.05) and shorter DFS (HR = 2.55; 95%CI = 1.05–6.21; p <0.05), while high CEA serum levels were associated with poor DFS (HR = 2.63; 95%CI = 1.01–6.85; p <0.05). Integrated clinical and molecular-based unsupervised analysis allowed us to identify two RC prognostic groups (cluster 1 and cluster 2) associated with disease-specific OS (HR = 20.64; 95%CI = 2.63–162.2; p <0.0001), metastasis-free survival (HR = 3.67; 95%CI = 1.22–11; p = 0.012), local recurrence-free survival (HR = 3.34; 95%CI = 0.96–11.6; p = 0.043) and worse DFS (HR = 2.68; 95%CI = 1.18–6.06; p = 0.012). The worst prognosis cluster 2 was enriched by stage III high-risk clinical tumors, poor responders to nCRT, with low TILs density and high frequency of KRAS and TP53 mutated cases compared with the best prognosis cluster 1 (p <0.05). Overall, this study provides a comprehensive and integrated characterization of non-metastatic RC cases as a new insight to deliver a personalized therapeutic approach.

NF-κB-Related Metabolic Gene Signature Predicts the Prognosis and Immunotherapy Response in Gastric Cancer

Background. Sufficient evidence indicated the crucial role of NF-κB family played in gastric cancer (GC). The novel discovery that NF-κB could regulate cancer metabolism and immune evasion greatly increased its attraction in cancer research. However, the correlation among NF-κB, metabolism, and cancer immunity in GC still requires further improvement. Methods. TCGA, hTFtarget, and MSigDB databases were employed to identify NF-κB-related metabolic genes (NFMGs). Based on NFMGs, we used consensus clustering to divide GC patients into two subtypes. GSVA was employed to analyze the enriched pathway. ESTIMATE, CIBERSORT, ssGSEA, and MCPcounter algorithms were applied to evaluate immune infiltration in GC. The tumor immune dysfunction and exclusion (TIDE) algorithm was used to predict patients’ response to immunotherapy. We also established a NFMG-related risk score by using the LASSO regression model and assessed its efficacy in TCGA and GSE62254 datasets. Results. We used 27 NFMGs to conduct an unsupervised clustering on GC samples and classified them into two clusters. Cluster 1 was characterized by high active metabolism, tumor mutant burden, and microsatellite instability, while cluster 2 was featured with high immune infiltration. Compared to cluster 2, cluster 1 had a better prognosis and higher response to immunotherapy. In addition, we constructed a 12-NFMG (ADCY3, AHCY, CHDH, GUCY1A2, ITPA, MTHFD2, NRP1, POLA1, POLR1A, POLR3A, POLR3K, and SRM) risk score. Followed analysis indicated that this risk score acted as an effectively prognostic factor in GC. Conclusion. Our data suggested that GC subtypes classified by NFMGs may effectively guide prognosis and immunotherapy. Further study of these NFMGs will deepen our understanding of NF-κB-mediated cancer metabolism and immunity.

Determinate Location Of MBKM Internship Based On Clusterring Student's Skills With K-Means (Case In Universitas PGRI Argopuro Jember)

The purpose of this study was to determinate location of MBKM internship based on clusterring student's skills with K-Means. This is important to detect some of student’s skills which will become the output of the university that must be recorded early so that they were truly ready to compete. To analyze the skills of some students, the Mathematics Education study program at the University of Argopuro Jember conducted a survey of additional skills outside of lectures. This survey is carried out regularly every year as material for reporting on the development of students' skills and qualities. Thus the skills possessed by students can be monitored and evaluated whether in the future special skills were needed that must be given to students. The skills of students who become points in the survey include: 1)Foreign language skills, 2)IT Skills, 3)Public Speaking and Management Skills, 4)Analitical and Graphic Design Skills, 5)Microteaching Skills. We clustering 67 respondent, it is our student at Universitas Argopuro Jember in fiveth. Cause of outlier in 7 respondent, we just make clustering with K-means with 60 respondent. Based on K-Means clusterring we have 3 cluster .It shows that cluster 1 has 32 respondents, cluster 2 has 21 respondents and cluster 3 has 7 respondents. Abd also on the result and discussion, we knew that cluster 1 with 32 respondent has more skills, it were foreign language, public speaking skills and microteaching skills. So the internship locations that match these skills clusters such as LBB then Publication Offices such as Radio, Jawapos, etc. For second conclusion, we knew that cluster 2 with 21 respondent have more skills except for microteaching skills. Appropriate internship places for these students are in administrative offices, local government offices, etc.And for third conclusion, that cluster 3 with 7 respondent have more skills too except public speaking but they have a middle skills in microteaching. The office or internship location where we can suggest is Dinas Parawisata, Perbankan that needs good communication and good team work, etc

PENGARUH MEDIA PEMBELAJARAN TEKNOLOGI AUGMENTED REALITY (AR) PADA TEMATIK TERPADU TERHADAP HASIL BELAJAR SISWA SD

This research is motivated by the absence of new technology based learning media in the integrated thematic learning process. Thios studdy aims to determine the effiect of Augomented Rveality( AR) tekhnology learning media on integrated thematic on student learning outcomes in grade IV SDN 005 Langgini, Bangkinang District in the even semester of the 2020/ 2021 akademic year. This reseiarch was conducted on Theme 8 Sub- theme 2 Learning 3 and 4. The type of research was quantitative in the foarm off a quasi exsperimental design. By design Nonequivalent control group design. The samplig technique is cluster random sampling. The populations consistead of several schools located in on cluster 2 Bangkinang District and grades IV A and IV B SDN 005 Langgini werw selected as samples. Class IV A as the control claess annd claess IV B as the experimental class. Based on the results of the study, the average value of the experimental class was 80, 00 wit a standarnd deviationsf of 8, 18 and the average value of the control class was 72, 22 wih a standarnd deviatian ef 8, 17. Baseaid om the calculatiop of th t- tst obtaind tcount 3, 1966 Whil the ttableat the confidece tingkat 0, 05 is 2, 017 so tha tcounnt ttble. Thuss, it can be conclded theat there is a positive and significbant effecth of using Augmented Reality( AR) technology learning media in integrated thematic on the learnisng outwcomes of fourth graode students at SDN 005 Langgini.

Collisions of Cortical Microtubules with Membrane Associated Myosin VIII Tail

The distribution of myosin VIII ATM1 tail in association with the plasma membrane is often observed in coordination with that of cortical microtubules (MTs). The prevailing hypothesis is that coordination between the organization of cortical MTs and proteins in the membrane results from the inhibition of free lateral diffusion of the proteins by barriers formed by MTs. Since the positioning of myosin VIII tail in the membrane is relatively stable, we ask: can it affect the organization of MTs? Myosin VIII ATM1 tail co-localized with remorin 6.6, the position of which in the plasma membrane is also relatively stable. Overexpression of myosin VIII ATM1 tail led to a larger fraction of MTs with a lower rate of orientation dispersion. In addition, collisions between MTs and cortical structures labeled by ATM1 tail or remorin 6.6 were observed. Collisions between EB1 labeled MTs and ATM1 tail clusters led to four possible outcomes: 1—Passage of MTs through the cluster; 2—Decreased elongation rate; 3—Disengagement from the membrane followed by a change in direction; and 4—retraction. EB1 tracks became straighter in the presence of ATM1 tail. Taken together, collisions of MTs with ATM1 tail labeled structures can contribute to their coordinated organization.

Perfil de trabalhadores da enfermagem de hospitais universitários e as cargas de trabalho: análise por cluster

Resumo Objetivo analisar o perfil sociodemográfico, laboral e a intensidade das cargas de trabalho de trabalhadores da enfermagem de hospitais universitários. Método quantitativo e transversal, com 361 trabalhadores de enfermagem, entre novembro de 2019 e fevereiro de 2020, por meio da Escala de Cargas de Trabalho nas Atividades de Enfermagem. Realizou-se análise de cluster. Resultados formaram-se quatro clusters com trabalhadores do sexo feminino (2, 3 e 4) e sexo masculino (1). A exposição às cargas de trabalho foi identificada como intensa (1, 2 e 3) e pouco intensa (4). As unidades de trabalho evidenciadas com mais frequência nos clusters 1, 2 e 3 foram a Rede de Urgência e Emergência, Pediátrica e Clínica Médica, e no cluster 4, a Maternidade e Clínica Cirúrgica. Os clusters 1 e 3 identificaram com mais frequência o período de trabalho de 1 a 5 anos, no cluster 2, foi de 15 a 20 anos, e no cluster 4, inferior a um ano. Conclusão e implicações para a prática a identificação dos quatro clusters possibilitou a análise do perfil de trabalhadores de enfermagem, permitindo o planejamento de intervenções direcionadas a minimizar as cargas de trabalho de acordo com as particularidades de cada grupo.

Perfil de usuários de um serviço de estomaterapia: análise de cluster

Resumo Objetivo Analisar o perfil das pessoas com estomias intestinais e/ou urinárias acompanhadas em serviço de estomaterapia, conforme variáveis sociodemográficas e clínicas. Método Trata-se de um estudo transversal, realizado com 90 usuários do serviço de estomaterapia. A coleta foi realizada de janeiro a fevereiro de 2020, por meio de dois instrumentos: COH-QOL-Ostomy, adaptado e traduzido para o contexto brasileiro; e City of Hope Quality of Life – Ostomy Questionnaire, instrumento original com questionário elaborado pelas próprias pesquisadoras, contemplando os aspectos sociodemográfico e clínico. Esses dados foram transferidos e organizados no Software Statistical Package for the Social Science, versão 22. Resultados Foram identificados quatro grupos distintos. No cluster 1, o grupo possui de duas a três complicações associadas ao estoma e 52,9% possuem colostomia. No cluster 2, 45% não apresentam nenhuma complicação e 70% têm urostomia. Já no cluster 3, a totalidade do grupo apresenta uma complicação e colostomia. E no cluster 4, nenhum participante do grupo apresenta complicação e todos têm colostomia. Conclusão e implicações para a prática O estudo proporcionou a geração de dados que podem auxiliar no planejamento do trabalho desenvolvido pelas equipes de saúde junto aos pacientes estomizados.

Medieval Authorship and Canonicity in the Digital Age – an Introduction

Jeroen Deploige and Jeroen De Gussem introduce Cluster 2 of Interfaces 8, on the topic of Medieval Authorship and Canonicity in the Digital Age.

Aplikasi Metode K-Medoid pada Pengelompokan Kabupaten/Kota di Jawa Barat Berdasarkan Indikator Indeks Pembangunan Manusia Tahun 2020

Masyarakat memiliki lebih banyak pilihan dalam memenuhi kebutuhan ekonomi, sosial dan budaya. Pembangunan Jawa Barat bukan hanya terpusat pada pemerataan, tetapi juga menekankan pada proses pembangunan dan perubahan, serta menekankan pada percepatan pertumbuhan dan pemerataan pembangunan Jawa Barat. Oleh karena itu, penting sebagai pertimbangan penggunaan Indeks Pembangunan Manusia (IPM) untuk mengelompokkan daerah/kota Jawa Barat. Metode kali ini menggunakan clustering K-Medoids, yang mengambil objek untuk perwakilan pusat cluster dari setiap cluster. Kelebihan dari algoritma K-Medoids adalah tidak sensitif kepada pencilan, sehingga objek yang mempunnyai nilai lebih dapat disimpan dalam distribusi data. Didapatkan pengelompokan dengan K-medoids clustering diperoleh hasil cluster 1 sebanyak 14 anggota sebagai kabupaten/kota dengan jumlah IPM yang rendah. Cluster 2 sebanyak 9 anggota sebagai kabupaten/kota dengan jumlah IPM yang sedang. Sedangkan cluster 3 sebanyak 4 anggota sebagai kabupaten/kota dengan jumlah IPM yang tinggi.