scholarly journals Quantitative Magnetic Resonance Imaging of the Pancreas of Individuals With Diabetes

2020 ◽  
Vol 11 ◽  
Author(s):  
John Virostko
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Exocrine Pancreas ◽  
Endocrine Pancreas ◽  
Quantitative Mri ◽  
Resonance Imaging ◽  
Clinical Tool ◽  
Quantitative Magnetic Resonance Imaging ◽  
Magnetic Resonance Imaging Mri ◽  
Image Analyses

Magnetic resonance imaging (MRI) has the potential to improve our understanding of diabetes and improve both diagnosis and monitoring of the disease. Although the spatial resolution of MRI is insufficient to directly image the endocrine pancreas in people, the increasing awareness that the exocrine pancreas is also involved in diabetes pathogenesis has spurred new MRI applications. These techniques build upon studies of exocrine pancreatic diseases, for which MRI has already developed into a routine clinical tool for diagnosis and monitoring of pancreatic cancer and pancreatitis. By adjusting the imaging contrast and carefully controlling image acquisition and processing, MRI can quantify a variety of tissue pathologies. This review introduces a number of quantitative MRI techniques that have been applied to study the diabetic pancreas, summarizes progress in validating and standardizing each technique, and discusses the need for image analyses that account for spatial heterogeneity in the pancreas.

Magnetic Resonance Imaging of Articular Cartilage within the Knee

2018 ◽  
Vol 31 (02) ◽  
pp. 155-165 ◽  
Author(s):  
Alissa Burge ◽  
Hollis Potter ◽  
Erin Argentieri
Keyword(s):  
Magnetic Resonance Imaging ◽  
Articular Cartilage ◽  
Magnetic Resonance ◽  
Cartilage Repair ◽  
Quantitative Mri ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Mri ◽  
Biochemical Assessment ◽  
Insight Into ◽  
Repair Techniques

AbstractMagnetic resonance imaging (MRI) provides an effective and noninvasive means by which to evaluate articular cartilage within the knee. Existing techniques can be utilized to detect and monitor longitudinal changes in cartilage status due to injury or progression of degenerative disease. Quantitative MRI (qMRI) techniques can provide a metric by which to evaluate the efficacy of cartilage repair techniques and offer insight into the composition of cartilage and cartilage repair tissue. In this review, we provide background on MR signal generation and decay, the utility of morphologic MRI assessment, and qMRI techniques for the biochemical assessment of cartilage (dGEMRIC, T2, T2*, T1ρ, sodium, gagCEST). Finally, the description and utility of these qMRI techniques for the evaluation of cartilage repair are discussed.

Antiuterotrophic effects of a pure antioestrogen, ICI 182,780: magnetic resonance imaging of the uterus in ovariectomized monkeys

1992 ◽  
Vol 135 (2) ◽  
pp. 239-NP ◽  
Author(s):  
M. Dukes ◽  
D. Miller ◽  
A. E. Wakeling ◽  
J. C. Waterton
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Quantitative Mri ◽  
Macaca Nemestrina ◽  
Dependent Manner ◽  
Resonance Imaging ◽  
Ici 182,780 ◽  
Uterine Involution ◽  
Magnetic Resonance Imaging Mri ◽  
Long Acting

ABSTRACT ICI 182,780 is a potent specific pure antioestrogen which may offer advantages in breast cancer treatment compared with partial agonists like tamoxifen. To characterize further the potency and efficacy of ICI 182,780, its effects on the uterus of ovariectomized, oestrogen-treated monkeys (Macaca nemestrina) have been measured using magnetic resonance imaging (MRI). Quantitative MRI allows accurate non-invasive repetitive measurements of endometrial and myometrial volume following hormonal treatments, using each animal as its own control. Single i.m. injections of a long-acting oil-based formulation of ICI 182,780 sustained blockade of oestradiol action on the monkey uterus in a dose-dependent manner for 3–6 weeks. Repeated injections of 4 mg ICI 182,780/kg at 4-weekly intervals provided increasingly effective blockade of uterine proliferation. In a short-acting formulation, ICI 182,780 also completely blocked the trophic action of oestradiol, administered concurrently, in ovariectomized monkeys. Similarly, ICI 182,780 caused involution of the uterus stimulated by prior treatment with oestradiol. The rate and extent of uterine involution in monkeys treated with ICI 182,780 was similar to that seen following oestrogen withdrawal. These studies demonstrate that ICI 182,780 is a fully effective pure antioestrogen in a primate. Journal of Endocrinology (1992) 135, 239–247

Sign in / Sign up

Export Citation Format

Share Document