Nuchal Skinfold Thickness in Pediatric Brain Tumor Patients

BackgroundSevere obesity and tumor relapse/progression have impact on long-term prognosis in pediatric brain tumor patients.MethodsIn a cross-sectional study, we analyzed nuchal skinfold thickness (NST) on magnetic-resonance imaging (MRI) follow-up monitoring as a parameter for assessment of nuchal adipose tissue in 177 brain tumor patients (40 World Health Organization (WHO) grade 1–2 brain tumor; 31 grade 3–4 brain tumor; 106 craniopharyngioma), and 53 healthy controls. Furthermore, body mass index (BMI), waist-to-height ratio, caliper-measured skinfold thickness, and blood pressure were analyzed for association with NST.ResultsCraniopharyngioma patients showed higher NST, BMI, waist-to-height ratio, and caliper-measured skinfold thickness when compared to other brain tumors and healthy controls. WHO grade 1–2 brain tumor patients were observed with higher BMI, waist circumference and triceps caliper-measured skinfold thickness when compared to WHO grade 3–4 brain tumor patients. NST correlated with BMI, waist-to-height ratio, and caliper-measured skinfold thickness. NST, BMI and waist-to-height ratio were associated with increased blood pressure. In craniopharyngioma patients with hypothalamic involvement/lesion or gross-total resection, rate and degree of obesity were increased.ConclusionsNST could serve as a novel useful marker for regional nuchal adipose tissue. NST is highly associated with body mass and waist-to-height ratio, and easily measurable in routine MRI monitoring of brain tumor patients.

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Body Composition and Nuchal Skinfold Thickness in Pediatric Brain Tumor Patients

Journal of the Endocrine Society ◽

10.1210/jendso/bvab048.1272 ◽

2021 ◽

Vol 5 (Supplement_1) ◽

pp. A624-A624

Author(s):

Junxiang Peng ◽

Svenja Boekhoff ◽

Maria Eveslage ◽

Panjarat Sowithayasakul ◽

Brigitte Bison ◽

...

Keyword(s):

Cardiovascular Disease ◽

Body Composition ◽

Brain Tumor ◽

Skinfold Thickness ◽

Healthy Controls ◽

Height Ratio ◽

Tumor Patients ◽

Who Grade ◽

Waist To Height Ratio

Abstract Obesity, cardiovascular disease, and relapse/progression have major impact on prognosis in pediatric brain tumor patients. Cranial MRI is part of routine follow-up. In a cross-sectional study, we analyzed nuchal skinfold thickness (NST) by a standardized method on MRI performed for brain tumor follow-up monitoring as a novel parameter for body composition and cardiovascular disease in 177 brain tumor patients (40 WHO grade 1-2 brain tumors; 31 grade 3-4 brain tumors; 106 craniopharyngioma), and 53 healthy controls. Associations of NST with body mass index (BMI), waist-to-height ratio, caliper-measured skinfold thickness, and blood pressure were analysed in brain tumor patients and healthy controls. Craniopharyngioma patients showed higher BMI, waist-to-height ratio, NST and caliper-measured skinfold thickness when compared with brain tumor patients and healthy controls, whereas these differences were not detectable between brain tumor patients and healthy controls. However, WHO grade 1-2 brain tumor patients were observed with higher BMI, waist circumference and caliper-measured triceps skinfold thickness when compared to WHO grade 3-4 brain tumor patients. NST showed high correlations with BMI, waist-to-height ratio, and caliper-measured skinfold thickness. NST, BMI and waist-to-height ratio had predictive value for cardiovascular disease in terms of increased blood pressure, and in multivariate analysis, only BMI was selected for the final model resulting in an odds ratio of 1.25 (1.14-1.379). In craniopharyngioma patients with hypothalamic involvement/lesion or gross-total resection, rate and degree of obesity were increased. As monitoring of MRI and body composition play an important role in follow-up after brain tumor, we conclude that NST could serve as a novel useful parameter for assessment of body composition and cardiovascular disease risk in brain tumor patients.

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Body Composition and Nuchal Skinfold Thickness in Pediatric Brain Tumor Patients

10.21203/rs.3.rs-138502/v1 ◽

2021 ◽

Author(s):

Junxiang Peng ◽

Svenja Boekhoff ◽

Maria Eveslage ◽

Brigitte Bison ◽

Panjarat Sowithayasakul ◽

...

Keyword(s):

Body Composition ◽

Brain Tumor ◽

Pediatric Brain Tumor ◽

Skinfold Thickness ◽

Cross Sectional Study ◽

Cvd Risk ◽

Cross Sectional ◽

Who Grade ◽

Grade 3 ◽

Pediatric Brain

Abstract Background: Obesity, cardiovascular disease (CVD), and relapse/progression have impact on prognosis in pediatric brain tumor (BT) patients. Methods: In a cross-sectional study, we analyzed nuchal skinfold thickness (NST) on MRI follow-up monitoring as a parameter for body composition (BC) and CVD in 177 BT patients (40 WHO grade 1–2 BT; 31 grade 3–4 BT; 106 craniopharyngioma (CP)), and 53 healthy controls (HC). Furthermore, BMI, waist-to-height ratio (WHtR), caliper-measured skinfold thickness (cSFT), and blood-pressure (BP) were analysed.Results: CP patients showed higher BMI, WHtR, NST and cSFT when compared with BT and HC. WHO grade 1–2 BT patients were observed with higher BMI, waist circumference and triceps cSFT when compared to WHO grade 3–4 BT patients. NST correlated with BMI, WHtR, and cSFT. NST, BMI and WHtR had predictive value for CVD in terms of increased BP. In multivariate analysis, only BMI was selected for the final model resulting in an odds ratio of 1.25 (1.14–1.379). In CP patients with hypothalamic involvement/lesion or gross-total resection, rate and degree of obesity were increased. Conclusions: NST could serve as a novel useful parameter for assessment of BC and CVD risk in BT patients.

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RARE-61. BODY COMPOSITION AND NUCHAL SKINFOLD THICKNESS IN PEDIATRIC BRAIN TUMOR PATIENTS

Neuro-Oncology ◽

10.1093/neuonc/noaa222.771 ◽

2020 ◽

Vol 22 (Supplement_3) ◽

pp. iii455-iii455

Author(s):

Junxiang Peng ◽

Svenja Boekhoff ◽

Maria Eveslage ◽

Brigitte Bison ◽

Panjarat Sowithayasakul ◽

...

Keyword(s):

Body Composition ◽

Brain Tumor ◽

Pediatric Brain Tumor ◽

Skinfold Thickness ◽

Cvd Risk ◽

Cross Sectional ◽

Who Grade ◽

Grade 3 ◽

Pediatric Brain

Abstract BACKGROUND Obesity, cardiovascular disease (CVD), and relapse/progression have major impact on prognosis in pediatric brain tumor (BT) patients. Cranial MRI is part of routine follow-up. METHODS In a cross-sectional study, we analyzed nuchal skinfold thickness (NST) on MRI performed for BT follow-up monitoring as a novel parameter for body composition (BC) and CVD in 177 BT patients (40 WHO grade 1–2 BT; 31 grade 3–4 BT; 106 craniopharyngioma (CP)), and 53 healthy controls (HC). Associations of NST with body mass index (BMI), waist-to-height ratio (WHtR), caliper-measured skinfold thickness (cSFT), and blood pressure (BP) were analysed in BT and HC. RESULTS CP patients showed higher BMI, WHtR, NST and cSFT when compared with BT and HC, whereas these differences were not detectable between BT and HC. However, WHO grade 1–2 BT patients were observed with higher BMI, waist circumference and triceps cSFT when compared to WHO grade 3–4 BT patients. NST showed high correlations with BMI, WHtR, and cSFT. NST, BMI and WHtR had predictive value for CVD in terms of increased BP, and in multivariate analysis, only BMI was selected for the final model resulting in an odds ratio of 1.25 (1.14–1.379). In CP patients with hypothalamic involvement/lesion or gross-total resection, rate and degree of obesity were increased. CONCLUSIONS As monitoring of MRI and BC play an important role in follow-up after BT, NST could serve as a novel useful parameter for assessment of BC and CVD risk in BT patients.

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LGG-32. CLINICAL OUTCOME OF PEDIATRIC GLIOMAS IN SINGLE INSTITUTION

Neuro-Oncology ◽

10.1093/neuonc/noaa222.414 ◽

2020 ◽

Vol 22 (Supplement_3) ◽

pp. iii372-iii372

Author(s):

Hiroyuki Uchida ◽

Nayuta Higa ◽

Hajime Yonezawa ◽

Tatsuki Oyoshi ◽

Koji Yoshimoto

Keyword(s):

Brain Tumor ◽

Tumor Resection ◽

Treatment Strategies ◽

Pediatric Brain Tumor ◽

University Hospital ◽

Subependymal Giant Cell Astrocytoma ◽

Histopathological Diagnosis ◽

Tumor Patients ◽

Who Grade ◽

Pediatric Brain

Abstract Gliomas in children are rarer than in adult, then treatment strategies might vary from facility to facility. We report clinical features and outcome of pediatric glioma in our institution. Twenty-nine patients diagnosed with glioma, exclude ependymoma, 14 boys and 15 girls, among 98 pediatric brain tumor patients treated at Kagoshima University Hospital since 2006 were reviewed histopathology, extent of resection, adjuvant therapy and outcome, etc. Mean age at surgery was 10.4 (S.D. 5.6) years. Median follow-up period was 19.1 months. Histopathological diagnosis comprised 8 pilocytic astrocytoma, 3 ganglioglioma, 2 subependymal giant cell astrocytoma, 5 WHO grade Ⅱ astrocytoma, 8 glioblastoma, and desmoplastic infantile astrocytoma, anaplastic astrocytoma and astroblastoma were one case each. Tumor resection was performed in 24 cases, and 5 cases underwent biopsy. Chemotherapy was performed in 15 cases and irradiation was performed in 9 cases. Out of 5 WHO grade Ⅱ astrocytoma cases, 2 cases underwent biopsy following chemotherapy, 1 case underwent biopsy only and other 1 case underwent total resection. The four cases show long survival ranged from 71 to 136 months without irradiation. All of eight glioblastoma cases show poor prognosis ranged from 8.6 to 26.7 months regardless of chemo-radiotherapy. In management for pediatric brain tumor patients, irradiation is often laid over until recurrence. In WHO grade Ⅱ astrocytoma, the treatment strategy might be reasonable using appropriate chemotherapy even though biopsy cases.

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Body composition and nuchal skinfold thickness in pediatric brain tumor patients

Endocrine Abstracts ◽

10.1530/endoabs.73.aep477 ◽

2021 ◽

Author(s):

Junxiang Peng ◽

Svenja Boekhoff ◽

Maria Eveslage ◽

Brigitte Bison ◽

Panjarat Sowithayasakul ◽

...

Keyword(s):

Body Composition ◽

Brain Tumor ◽

Pediatric Brain Tumor ◽

Skinfold Thickness ◽

Tumor Patients ◽

Pediatric Brain

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Benefit of Static FET PET in Pretreated Pediatric Brain Tumor Patients with Equivocal Conventional MRI Results

Klinische Pädiatrie ◽

10.1055/a-1335-4844 ◽

2021 ◽

Author(s):

Frederik Grosse ◽

Florian Wedel ◽

Ulrich-Wilhelm Thomale ◽

Ingo Steffen ◽

Arend Koch ◽

...

Keyword(s):

Brain Tumor ◽

Tumor Tissue ◽

Pediatric Brain Tumor ◽

Ct Scans ◽

Tumor Patients ◽

Fet Pet ◽

Conventional Mri ◽

Pet Ct ◽

Pediatric Brain

Abstract Background MRI has shortcomings in differentiation between tumor tissue and post-therapeutic changes in pretreated brain tumor patients. Patients We assessed 22 static FET-PET/CT-scans of 17 pediatric patients (median age 12 years, range 2–16 years, ependymoma n=4, medulloblastoma n=4, low-grade glioma n=6, high-grade glioma n=3, germ cell tumor n=1, choroid plexus tumor n=1, median follow-up: 112 months) with multimodal treatment. Method FET-PET/CT-scans were analyzed visually by 3 independent nuclear medicine physicians. Additionally quantitative FET-Uptake for each lesion was determined by calculating standardized uptake values (SUVmaxT/SUVmeanB, SUVmeanT/SUVmeanB). Histology or clinical follow-up served as reference. Results Static FET-PET/CT reliably distinguished between tumor tissue and post-therapeutic changes in 16 out of 17 patients. It identified correctly vital tumor tissue in 13 patients and post-therapeutic changes in 3 patients. SUV-based analyses were less sensitive than visual analyses. Except from a choroid plexus carcinoma, all tumor entities showed increased FET-uptake. Discussion Our study comprises a limited number of patients but results corroborate the ability of FET to detect different brain tumor entities in pediatric patients and discriminate between residual/recurrent tumor and post-therapeutic changes. Conclusions We observed a clear benefit from additional static FET-PET/CT-scans when conventional MRI identified equivocal lesions in pretreated pediatric brain tumor patients. These results warrant prospective studies that should include dynamic scans.

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