Body Composition and Nuchal Skinfold Thickness in Pediatric Brain Tumor Patients

Abstract Obesity, cardiovascular disease, and relapse/progression have major impact on prognosis in pediatric brain tumor patients. Cranial MRI is part of routine follow-up. In a cross-sectional study, we analyzed nuchal skinfold thickness (NST) by a standardized method on MRI performed for brain tumor follow-up monitoring as a novel parameter for body composition and cardiovascular disease in 177 brain tumor patients (40 WHO grade 1-2 brain tumors; 31 grade 3-4 brain tumors; 106 craniopharyngioma), and 53 healthy controls. Associations of NST with body mass index (BMI), waist-to-height ratio, caliper-measured skinfold thickness, and blood pressure were analysed in brain tumor patients and healthy controls. Craniopharyngioma patients showed higher BMI, waist-to-height ratio, NST and caliper-measured skinfold thickness when compared with brain tumor patients and healthy controls, whereas these differences were not detectable between brain tumor patients and healthy controls. However, WHO grade 1-2 brain tumor patients were observed with higher BMI, waist circumference and caliper-measured triceps skinfold thickness when compared to WHO grade 3-4 brain tumor patients. NST showed high correlations with BMI, waist-to-height ratio, and caliper-measured skinfold thickness. NST, BMI and waist-to-height ratio had predictive value for cardiovascular disease in terms of increased blood pressure, and in multivariate analysis, only BMI was selected for the final model resulting in an odds ratio of 1.25 (1.14-1.379). In craniopharyngioma patients with hypothalamic involvement/lesion or gross-total resection, rate and degree of obesity were increased. As monitoring of MRI and body composition play an important role in follow-up after brain tumor, we conclude that NST could serve as a novel useful parameter for assessment of body composition and cardiovascular disease risk in brain tumor patients.

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Nuchal Skinfold Thickness in Pediatric Brain Tumor Patients

Frontiers in Endocrinology ◽

10.3389/fendo.2021.772856 ◽

2021 ◽

Vol 12 ◽

Author(s):

Junxiang Peng ◽

Svenja Boekhoff ◽

Maria Eveslage ◽

Brigitte Bison ◽

Panjarat Sowithayasakul ◽

...

Keyword(s):

Brain Tumor ◽

Pediatric Brain Tumor ◽

Skinfold Thickness ◽

Healthy Controls ◽

Height Ratio ◽

Tumor Patients ◽

Who Grade ◽

Waist To Height Ratio ◽

Grade 3 ◽

Pediatric Brain

BackgroundSevere obesity and tumor relapse/progression have impact on long-term prognosis in pediatric brain tumor patients.MethodsIn a cross-sectional study, we analyzed nuchal skinfold thickness (NST) on magnetic-resonance imaging (MRI) follow-up monitoring as a parameter for assessment of nuchal adipose tissue in 177 brain tumor patients (40 World Health Organization (WHO) grade 1–2 brain tumor; 31 grade 3–4 brain tumor; 106 craniopharyngioma), and 53 healthy controls. Furthermore, body mass index (BMI), waist-to-height ratio, caliper-measured skinfold thickness, and blood pressure were analyzed for association with NST.ResultsCraniopharyngioma patients showed higher NST, BMI, waist-to-height ratio, and caliper-measured skinfold thickness when compared to other brain tumors and healthy controls. WHO grade 1–2 brain tumor patients were observed with higher BMI, waist circumference and triceps caliper-measured skinfold thickness when compared to WHO grade 3–4 brain tumor patients. NST correlated with BMI, waist-to-height ratio, and caliper-measured skinfold thickness. NST, BMI and waist-to-height ratio were associated with increased blood pressure. In craniopharyngioma patients with hypothalamic involvement/lesion or gross-total resection, rate and degree of obesity were increased.ConclusionsNST could serve as a novel useful marker for regional nuchal adipose tissue. NST is highly associated with body mass and waist-to-height ratio, and easily measurable in routine MRI monitoring of brain tumor patients.

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RARE-61. BODY COMPOSITION AND NUCHAL SKINFOLD THICKNESS IN PEDIATRIC BRAIN TUMOR PATIENTS

Neuro-Oncology ◽

10.1093/neuonc/noaa222.771 ◽

2020 ◽

Vol 22 (Supplement_3) ◽

pp. iii455-iii455

Author(s):

Junxiang Peng ◽

Svenja Boekhoff ◽

Maria Eveslage ◽

Brigitte Bison ◽

Panjarat Sowithayasakul ◽

...

Keyword(s):

Body Composition ◽

Brain Tumor ◽

Pediatric Brain Tumor ◽

Skinfold Thickness ◽

Cvd Risk ◽

Cross Sectional ◽

Who Grade ◽

Grade 3 ◽

Pediatric Brain

Abstract BACKGROUND Obesity, cardiovascular disease (CVD), and relapse/progression have major impact on prognosis in pediatric brain tumor (BT) patients. Cranial MRI is part of routine follow-up. METHODS In a cross-sectional study, we analyzed nuchal skinfold thickness (NST) on MRI performed for BT follow-up monitoring as a novel parameter for body composition (BC) and CVD in 177 BT patients (40 WHO grade 1–2 BT; 31 grade 3–4 BT; 106 craniopharyngioma (CP)), and 53 healthy controls (HC). Associations of NST with body mass index (BMI), waist-to-height ratio (WHtR), caliper-measured skinfold thickness (cSFT), and blood pressure (BP) were analysed in BT and HC. RESULTS CP patients showed higher BMI, WHtR, NST and cSFT when compared with BT and HC, whereas these differences were not detectable between BT and HC. However, WHO grade 1–2 BT patients were observed with higher BMI, waist circumference and triceps cSFT when compared to WHO grade 3–4 BT patients. NST showed high correlations with BMI, WHtR, and cSFT. NST, BMI and WHtR had predictive value for CVD in terms of increased BP, and in multivariate analysis, only BMI was selected for the final model resulting in an odds ratio of 1.25 (1.14–1.379). In CP patients with hypothalamic involvement/lesion or gross-total resection, rate and degree of obesity were increased. CONCLUSIONS As monitoring of MRI and BC play an important role in follow-up after BT, NST could serve as a novel useful parameter for assessment of BC and CVD risk in BT patients.

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Body Composition and Nuchal Skinfold Thickness in Pediatric Brain Tumor Patients

10.21203/rs.3.rs-138502/v1 ◽

2021 ◽

Author(s):

Junxiang Peng ◽

Svenja Boekhoff ◽

Maria Eveslage ◽

Brigitte Bison ◽

Panjarat Sowithayasakul ◽

...

Keyword(s):

Body Composition ◽

Brain Tumor ◽

Pediatric Brain Tumor ◽

Skinfold Thickness ◽

Cross Sectional Study ◽

Cvd Risk ◽

Cross Sectional ◽

Who Grade ◽

Grade 3 ◽

Pediatric Brain

Abstract Background: Obesity, cardiovascular disease (CVD), and relapse/progression have impact on prognosis in pediatric brain tumor (BT) patients. Methods: In a cross-sectional study, we analyzed nuchal skinfold thickness (NST) on MRI follow-up monitoring as a parameter for body composition (BC) and CVD in 177 BT patients (40 WHO grade 1–2 BT; 31 grade 3–4 BT; 106 craniopharyngioma (CP)), and 53 healthy controls (HC). Furthermore, BMI, waist-to-height ratio (WHtR), caliper-measured skinfold thickness (cSFT), and blood-pressure (BP) were analysed.Results: CP patients showed higher BMI, WHtR, NST and cSFT when compared with BT and HC. WHO grade 1–2 BT patients were observed with higher BMI, waist circumference and triceps cSFT when compared to WHO grade 3–4 BT patients. NST correlated with BMI, WHtR, and cSFT. NST, BMI and WHtR had predictive value for CVD in terms of increased BP. In multivariate analysis, only BMI was selected for the final model resulting in an odds ratio of 1.25 (1.14–1.379). In CP patients with hypothalamic involvement/lesion or gross-total resection, rate and degree of obesity were increased. Conclusions: NST could serve as a novel useful parameter for assessment of BC and CVD risk in BT patients.

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Body composition and nuchal skinfold thickness in pediatric brain tumor patients

Endocrine Abstracts ◽

10.1530/endoabs.73.aep477 ◽

2021 ◽

Author(s):

Junxiang Peng ◽

Svenja Boekhoff ◽

Maria Eveslage ◽

Brigitte Bison ◽

Panjarat Sowithayasakul ◽

...

Keyword(s):

Body Composition ◽

Brain Tumor ◽

Pediatric Brain Tumor ◽

Skinfold Thickness ◽

Tumor Patients ◽

Pediatric Brain

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Is waist-to-height ratio the best predictive indicator of cardiovascular disease incidence in hypertensive adults? A cohort study

10.21203/rs.3.rs-744910/v1 ◽

2021 ◽

Author(s):

Yingxian Sun ◽

Shu Zhang ◽

Xin Fu ◽

Zhi Du ◽

Xiaofan Guo ◽

...

Keyword(s):

Cardiovascular Disease ◽

Cohort Study ◽

Rural Areas ◽

Disease Incidence ◽

Positive Association ◽

Adverse Outcomes ◽

Height Ratio ◽

Cvd Risk ◽

Waist To Height Ratio

Abstract Background Cardiovascular disease (CVD) brings high mortality and economic burden to patients, especially in rural areas. Simple, low-cost abdominal adiposity measures may help identify individuals with increased CVD risk. It is unclear that which obesity indice is the best to predict CVD in hypertensive people. Methods NCRCHS is a prospective cohort study in a general population in Northeast China. The study examined the cardiovascular health from 2013–2015, and follow-up captured the CVD incidence in 2018. Baseline waist-to-height ratio (WHtR), body mass index (BMI),waist-to-hip(WHR)and waist circumference (WC) were calculated and analyzed in relation to the CVD incidence. Results A total of 4244 hypertensive adults without pre-existing CVD at baseline were included in this analysis (age 35–92 years; 2108 men). Over a median follow-up of 4.66 years, a total of 290 CVD cases (6.83%) were documented during the follow-up. Baseline WHtR showed a significant positive association with CVD incidence, even after adjusting for age, sex, diabetes, drinking, smoking, SBP, DBP, Triglyceride, HDL-C, LDL-C, and TC (Hazard Ratios per SD of WHtR ranging from 1.03 to 1.31, p = 0.017). Reclassification and discrimination analyses indicated WHtR addition could improve the conventional model for predicting adverse outcomes within 4 years. Moreover, WHtR predicted the CVD incidence better than other obesity indices (BMI, WC, WHR). Conclusion These findings support a positive association between WHtR and CVD incidence in CVD-free hypertensive adults. WHtR may be useful in predicting CVD incidence in hypertensive adults.

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Is Waist-To-Height Ratio The Best Predictive Indicator of Cardiovascular Disease Incidence in Hypertensive Adults? A Cohort Study

10.21203/rs.3.rs-752424/v1 ◽

2021 ◽

Author(s):

Shu Zhang ◽

Xin Fu ◽

Zhi Du ◽

Xiaofan Guo ◽

Zhao Li ◽

...

Keyword(s):

Cardiovascular Disease ◽

Cohort Study ◽

Rural Areas ◽

Disease Incidence ◽

Positive Association ◽

Adverse Outcomes ◽

Height Ratio ◽

Cvd Risk ◽

Waist To Height Ratio

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Effectiveness of a Multidisciplinary Lifestyle Intervention to Reduce Obesity among Children and Adolescents

Dhaka Shishu (Children) Hospital Journal ◽

10.3329/dshj.v35i2.49691 ◽

2020 ◽

Vol 35 (2) ◽

pp. 111-118

Author(s):

Md Rizwanul Ahsan ◽

Sabrina Makbul ◽

Probir Kumar Sarkar

Keyword(s):

Body Composition ◽

Body Weight ◽

Children And Adolescents ◽

Physical Performance ◽

Cardiometabolic Risk ◽

Dietary Habits ◽

Obese Children ◽

Height Ratio ◽

Waist To Height Ratio ◽

Family Based

Background: Now a days unhealthy lifestyle primarily responsible for the dramatic increase obesity among children and adolescents. Objective: The purpose of the study is to see the effects of a multidisciplinary lifestyle intervention to reduce obese children and adolescents. The main outcome was cardiometabolic risk based on the waist-to-height ratio (WHTR) measurement. Secondary outcomes were (1) changes in body composition; (2) adherence to a Mediterranean diet; and (3) physical performance. Methods: The study involved 64 overweight/obese children or adolescents conducted at Dhaka Shishu Hospital from October 2017 to September 2018. The intervention was multidisciplinary including nutrition, exercise, and psychological aspects based on a family-based approach; it was delivered for six months for children and three months for adolescents. Before and after the intervention, several anthropometric measures height, body weight, body mass index (BMI), waist circumference, and body composition, cardiometabolic risk index waist-to-height ratio (WHTR), and dietary habits of the participants and their families were evaluated. In addition, a set of functional motor fitness tests was performed to evaluate physical performance measures. Results: After the intervention both children and adolescents showed a significant reduction in body weight, BMI, waist circumference, fat mass, and WHTR index and an improvement of fat-free mass, adherence to the Mediterranean diet, and physical fitness performance. Conclusion: A short term family-based multidisciplinary approach is effective in ameliorating the health status, dietary habits, and physical performance in children and adolescents. DS (Child) H J 2019; 35(2) : 111-118

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Benefit of Static FET PET in Pretreated Pediatric Brain Tumor Patients with Equivocal Conventional MRI Results

Klinische Pädiatrie ◽

10.1055/a-1335-4844 ◽

2021 ◽

Author(s):

Frederik Grosse ◽

Florian Wedel ◽

Ulrich-Wilhelm Thomale ◽

Ingo Steffen ◽

Arend Koch ◽

...

Keyword(s):

Brain Tumor ◽

Tumor Tissue ◽

Pediatric Brain Tumor ◽

Ct Scans ◽

Tumor Patients ◽

Fet Pet ◽

Conventional Mri ◽

Pet Ct ◽

Pediatric Brain

Abstract Background MRI has shortcomings in differentiation between tumor tissue and post-therapeutic changes in pretreated brain tumor patients. Patients We assessed 22 static FET-PET/CT-scans of 17 pediatric patients (median age 12 years, range 2–16 years, ependymoma n=4, medulloblastoma n=4, low-grade glioma n=6, high-grade glioma n=3, germ cell tumor n=1, choroid plexus tumor n=1, median follow-up: 112 months) with multimodal treatment. Method FET-PET/CT-scans were analyzed visually by 3 independent nuclear medicine physicians. Additionally quantitative FET-Uptake for each lesion was determined by calculating standardized uptake values (SUVmaxT/SUVmeanB, SUVmeanT/SUVmeanB). Histology or clinical follow-up served as reference. Results Static FET-PET/CT reliably distinguished between tumor tissue and post-therapeutic changes in 16 out of 17 patients. It identified correctly vital tumor tissue in 13 patients and post-therapeutic changes in 3 patients. SUV-based analyses were less sensitive than visual analyses. Except from a choroid plexus carcinoma, all tumor entities showed increased FET-uptake. Discussion Our study comprises a limited number of patients but results corroborate the ability of FET to detect different brain tumor entities in pediatric patients and discriminate between residual/recurrent tumor and post-therapeutic changes. Conclusions We observed a clear benefit from additional static FET-PET/CT-scans when conventional MRI identified equivocal lesions in pretreated pediatric brain tumor patients. These results warrant prospective studies that should include dynamic scans.

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