scholarly journals Impact of Chronic Viral Infection on T-Cell Dependent Humoral Immune Response

2017 ◽  
Vol 8 ◽  
Author(s):  
Stéphane Rodriguez ◽  
Mikaël Roussel ◽  
Karin Tarte ◽  
Patricia Amé-Thomas
Keyword(s):  
Immune Response ◽  
T Cell ◽  
Viral Infection ◽  
Humoral Immune Response ◽  
Chronic Viral Infection ◽  
Humoral Immune

Global Stability and Hopf Bifurcation in a Delayed Viral Infection Model with Cell-to-Cell Transmission and Humoral Immune Response

2019 ◽  
Vol 29 (12) ◽  
pp. 1950161 ◽  
Author(s):  
Jinhu Xu ◽  
Yan Geng ◽  
Suxia Zhang
Keyword(s):  
Immune Response ◽  
Hopf Bifurcation ◽  
Viral Infection ◽  
Humoral Immune Response ◽  
Dynamical Behavior ◽  
Infection Model ◽  
Humoral Immune ◽  
Cell Transmission ◽  
Viral Infection Model ◽  
Intracellular Delays

We have developed a class of viral infection model with cell-to-cell transmission and humoral immune response. The model addresses both immune and intracellular delays. We also constructed Lyapunov functionals to establish the global dynamical properties of the equilibria. Theoretical results indicate that considering only two intracellular delays did not affect the dynamical behavior of the model, but incorporating an immune delay greatly affects the dynamics, i.e. an immune delay may destabilize the immunity-activated equilibrium and lead to Hopf bifurcation, oscillations and stability switches. Our results imply that an immune delay dominates the intracellular delays in the model. We also investigated the direction of the Hopf bifurcation and the stability of the periodic solutions by applying normal form and center manifold theory, and investigated the existence of global Hopf bifurcation by regarding the immune delay as a bifurcation parameter. Numerical simulations are carried out to support the analytical conclusions.

scholarly journals Antioxidant Treatment Regulates the Humoral Immune Response during Acute Viral Infection

2012 ◽  
Vol 87 (5) ◽  
pp. 2577-2586 ◽  
Author(s):  
K. E. Crump ◽  
P. K. Langston ◽  
S. Rajkarnikar ◽  
J. M. Grayson
Keyword(s):  
Immune Response ◽  
Viral Infection ◽  
Humoral Immune Response ◽  
Antioxidant Treatment ◽  
Humoral Immune ◽  
Acute Viral Infection

scholarly journals Association between Reactogenicity and Immunogenicity after Vaccination with BNT162b2

Vaccines ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1089
Author(s):  
Stilla Bauernfeind ◽  
Bernd Salzberger ◽  
Florian Hitzenbichler ◽  
Karolina Scigala ◽  
Sebastian Einhauser ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cell ◽  
Immune Responses ◽  
Humoral Immune Response ◽  
Adverse Reactions ◽  
Medical Center ◽  
Neutralization Activity ◽  
Humoral Immune ◽  
Cell Mediated Immune Response ◽  
Severe Adverse Reactions

It is not clear whether there is an association between adverse reactions and immune response after vaccination. Seven hundred and thirty-five vaccinees from our University Medical Center vaccination clinic provided information about sex, age and adverse reactions after first and second vaccination with BNT162b2. Adverse reactions were categorized into three groups: no or minor on the injection side, moderate (not further classified) and severe—defined as any symptom(s) resulting in sick leave. We chose 38 vaccinees with the most severe adverse reactions and compared their humoral and T-cell-mediated immune responses after second vaccination with those of 38 sex and age matched controls without or only minor injection-side related adverse reactions. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) anti-receptor binding domain (RBD) IgG titers were detectable in all participants (median 5528; range 958–26,285). Men with severe adverse reactions had 1.5-fold higher median SARS-CoV-2 RBD IgG titers compared to men without adverse reactions (median 7406 versus 4793; p < 0.001). Similarly; neutralization activity was significantly higher in men with severe adverse reactions (half maximal inhibitory concentrations (IC50) median 769 versus 485; p < 0.001). Reactogenicity did not influence humoral immune response in women nor T-cell-mediated immune response in any sex. To conclude; adverse reactions after vaccination with BNT162b2 do influence humoral immune response yet only in men and are not a prerequisite for a robust antibody response.

scholarly journals Neonatally Induced Inactivation of the Vascular Cell Adhesion Molecule 1 Gene Impairs B Cell Localization and T Cell–Dependent Humoral Immune Response

2001 ◽  
Vol 193 (6) ◽  
pp. 755-768 ◽  
Author(s):  
Christoph E. Leuker ◽  
Mark Labow ◽  
Werner Müller ◽  
Norbert Wagner
Keyword(s):  
Immune Response ◽  
T Cell ◽  
B Cells ◽  
B Cell ◽  
Adhesion Molecule ◽  
Humoral Immune Response ◽  
Cellular Adhesion ◽  
Humoral Immune ◽  
Cell Localization ◽  
Cellular Adhesion Molecule

Vascular cellular adhesion molecule (VCAM)-1 is a membrane-bound cellular adhesion molecule that mediates adhesive interactions between hematopoietic progenitor cells and stromal cells in the bone marrow (BM) and between leukocytes and endothelial as well as dendritic cells. Since VCAM-1–deficient mice die embryonically, conditional VCAM-1 mutant mice were generated to analyze the in vivo function of this adhesion molecule. Here we show that interferon-induced Cre-loxP–mediated deletion of the VCAM-1 gene after birth efficiently ablates expression of VCAM-1 in most tissues like, for example, BM, lymphoid organs, and lung, but not in brain. Induced VCAM-1 deficiency leads to a reduction of immature B cells in the BM and to an increase of these cells in peripheral blood but not in lymphoid organs. Mature recirculating B cells are reduced in the BM. In a migration assay, the number of mature B cells that appears in the BM after intravenous injection is decreased. In addition, the humoral immune response to a T cell–dependent antigen is impaired. VCAM-1 serves an important role for B cell localization and the T cell–dependent humoral immune response.

scholarly journals B and CD4+ T-cell expression of TLR2 is critical for optimal induction of a T-cell-dependent humoral immune response to intact Streptococcus pneumoniae

2008 ◽  
Vol 38 (12) ◽  
pp. 3316-3326 ◽  
Author(s):  
Sam Vasilevsky ◽  
Gouri Chattopadhyay ◽  
Jesus Colino ◽  
Tze-Jou Yeh ◽  
Quanyi Chen ◽  
...  
Keyword(s):  
Immune Response ◽  
Streptococcus Pneumoniae ◽  
T Cell ◽  
Humoral Immune Response ◽  
Cd4 T Cell ◽  
Humoral Immune ◽  
Cell Expression

scholarly journals AJP001, a novel helper T‐cell epitope, induces a humoral immune response with activation of innate immunity when included in a peptide vaccine

2019 ◽  
Vol 1 (12) ◽  
pp. 760-772 ◽  
Author(s):  
Akiko Tenma ◽  
Hironori Nakagami ◽  
Hideki Tomioka ◽  
Makoto Sakaguchi ◽  
Ryoko Ide ◽  
...  
Keyword(s):  
Immune Response ◽  
Innate Immunity ◽  
T Cell ◽  
Humoral Immune Response ◽  
Peptide Vaccine ◽  
Cell Epitope ◽  
T Cell Epitope ◽  
Helper T Cell ◽  
Humoral Immune
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