scholarly journals A Review of Clinical Disease Scoring Systems for Cicatricial Diseases of the Conjunctiva

2021 ◽  
Vol 8 ◽  
Author(s):  
Hon Shing Ong ◽  
John K. Dart ◽  
Jodhbir S. Mehta
Keyword(s):  
Ocular Surface ◽  
Visual Loss ◽  
Scoring Systems ◽  
Objective Evaluation ◽  
Clinical Disease ◽  
Diverse Group ◽  
International Consensus ◽  
Ocular Surface Diseases ◽  
Ocular Morbidity ◽  
Disease Scoring

Cicatricial conjunctival diseases (CCDs), are a diverse group of ocular surface diseases characterized by chronic scarring of the conjunctiva. These diseases can cause significant ocular morbidity. They are life-long once acquired and can be debilitating, painful diseases leading to visual loss. A recent international consensus of ocular surface disease experts have placed emphasis on the need of validated clinical disease scoring systems for CCDs, important for the objective evaluation of disease severity, outcomes of therapies, and longitudinal monitoring of disease. This review aims to describe the various published clinical disease scoring systems available for CCDs and evaluates the benefits and limitations of each system. It can be used as a guide for clinicians managing patients with CCDs and for researchers evaluating potential therapies in clinical trials.

scholarly journals Use of Acellular Umbilical Cord-Derived Tissues in Corneal and Ocular Surface Diseases

Medicines ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. 12
Author(s):  
Arianna A. Tovar ◽  
Ian A. White ◽  
Alfonso L. Sabater
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Ocular Surface ◽  
Cellular Proliferation ◽  
Mononuclear Cells ◽  
Autologous Serum ◽  
High Concentration ◽  
Ocular Surface Diseases ◽  
Natural Healing

Blood derived products have become a valuable source of tissue for the treatment of ocular surface diseases that are refractory to conventional treatments. These can be obtained from autologous or allogeneic sources (patient’s own blood or from healthy adult donors/umbilical cord blood, respectively). Allogeneic cord blood demonstrates practical advantages over alternatives and these advantages will be discussed herein. Umbilical cord blood (UCB) can be divided, generally speaking, into two distinct products: first, mononuclear cells, which can be used in regenerative ophthalmology, and second, the plasma/serum (an acellular fraction), which may be used in the form of eyedrops administered directly to the damaged ocular surface. The rationale for using umbilical cord serum (UCS) to treat ocular surface diseases such as severe dry eye syndrome (DES), persistent epithelial defects (PED), recurrent epithelial erosions, ocular chemical burns, graft versus host disease (GVHD), among others, is the considerably high concentration of growth factors and cytokines, mimicking the natural healing properties of human tears. Allogeneic serum also offers the opportunity for therapeutic treatment to patients who, due to poor heath, cannot provide autologous serum. The mechanism of action involves the stimulation of endogenous cellular proliferation, differentiation and maturation, which is highly efficient in promoting and enhancing corneal epithelial healing where other therapies have previously failed.

Amniotic membrane extract eye drops for ocular surface diseases: use and clinical outcome in real-world practice

2021 ◽  
Author(s):  
Noelia Sabater-Cruz ◽  
◽  
Marc Figueras-Roca ◽  
Miriam Ferrán-Fuertes ◽  
Elba Agustí ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Amniotic Membrane ◽  
Real World ◽  
Ocular Surface ◽  
Eye Drops ◽  
Ocular Surface Diseases ◽  
Membrane Extract

Ocular surface diseases and corneal refractive surgery

2014 ◽  
Vol 25 (4) ◽  
pp. 264-269 ◽  
Author(s):  
Debora Garcia-Zalisnak ◽  
David Nash ◽  
Elizabeth Yeu
Keyword(s):  
Ocular Surface ◽  
Refractive Surgery ◽  
Ocular Surface Diseases ◽  
Corneal Refractive Surgery

Smog analysis and its effect on reported ocular surface diseases: A case study of 2016 smog event of Lahore

2019 ◽  
Vol 198 ◽  
pp. 257-264 ◽  
Author(s):  
Arooj Ashraf ◽  
Aleem Butt ◽  
Imran Khalid ◽  
Rao Umair Alam ◽  
Sajid Rashid Ahmad
Keyword(s):  
Ocular Surface ◽  
Ocular Surface Diseases

Reconsidering the central role of mucins in dry eye and ocular surface diseases

2019 ◽  
Vol 71 ◽  
pp. 68-87 ◽  
Author(s):  
Christophe Baudouin ◽  
Maurizio Rolando ◽  
Jose M. Benitez Del Castillo ◽  
Elisabeth M. Messmer ◽  
Francisco C. Figueiredo ◽  
...  
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Ocular Surface Diseases

scholarly journals Penetrating Ocular Trauma Caused by Steel Wire from a Rotating Wire Brush: A Case Report with Review of Literature

2021 ◽  
Vol 3 (2) ◽  
pp. 49-52
Author(s):  
Sagili Chandrasekhara Reddy
Keyword(s):  
Visual Loss ◽  
Ocular Trauma ◽  
Steel Wire ◽  
Eye Drops ◽  
Review Of Literature ◽  
Eye Injuries ◽  
Thin Steel ◽  
Ocular Morbidity ◽  
Full Face ◽  
Penetrating Ocular Trauma

A 19-year-old young man came to emergency department with a complaint of injury in the left eye with a wire, while cleaning the car engine parts in the workshop with motorized rotating wire brush. He was referred immediately to the eye clinic. On examination of the left eye, a thin steel wire was seen penetrating at the nasal limbus which was projecting forwards. The wire was removed (33 mm in length) under aseptic precautions using topical anaesthesia. Postoperatively, he was treated with ciprofloxacin eye drops. The patient had no ocular morbidity; the vision was normal, and he was asymptomatic in the left eye. Eye injuries from rotating wire brushes are caused by detached fragments. These eyes should be examined in detail for the involvement of different structures of the eye; and should be treated adequately in-time to prevent visual loss/ blindness. Wearing of safety glasses/ full face shield while working is recommended to prevent such injuries.

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