scholarly journals Red Blood Cell Classification Based on Attention Residual Feature Pyramid Network

2021 ◽  
Vol 8 ◽  
Author(s):  
Weiqing Song ◽  
Pu Huang ◽  
Jing Wang ◽  
Yajuan Shen ◽  
Jian Zhang ◽  
...  

Clinically, red blood cell abnormalities are closely related to tumor diseases, red blood cell diseases, internal medicine, and other diseases. Red blood cell classification is the key to detecting red blood cell abnormalities. Traditional red blood cell classification is done manually by doctors, which requires a lot of manpower produces subjective results. This paper proposes an Attention-based Residual Feature Pyramid Network (ARFPN) to classify 14 types of red blood cells to assist the diagnosis of related diseases. The model performs classification directly on the entire red blood cell image. Meanwhile, a spatial attention mechanism and channel attention mechanism are combined with residual units to improve the expression of category-related features and achieve accurate extraction of features. Besides, the RoI align method is used to reduce the loss of spatial symmetry and improve classification accuracy. Five hundred and eighty eight red blood cell images are used to train and verify the effectiveness of the proposed method. The Channel Attention Residual Feature Pyramid Network (C-ARFPN) model achieves an mAP of 86%; the Channel and Spatial Attention Residual Feature Pyramid Network (CS-ARFPN) model achieves an mAP of 86.9%. The experimental results indicate that our method can classify more red blood cell types and better adapt to the needs of doctors, thus reducing the doctor's time and improving the diagnosis efficiency.

2020 ◽  
Vol 28 (22) ◽  
pp. 33504 ◽  
Author(s):  
Timothy O’Connor ◽  
Christopher Hawxhurst ◽  
Leslie M. Shor ◽  
Bahram Javidi

2020 ◽  
Vol 1444 ◽  
pp. 012036 ◽  
Author(s):  
Budi Sunarko ◽  
Djuniadi ◽  
Murk Bottema ◽  
Nur Iksan ◽  
Khakim A N Hudaya ◽  
...  

2013 ◽  
Vol 99 ◽  
pp. 98-110 ◽  
Author(s):  
Taoyi Chen ◽  
Yong Zhang ◽  
Changhong Wang ◽  
Zhenshen Qu ◽  
Fei Wang ◽  
...  

2012 ◽  
Vol 2012 ◽  
pp. 1-15 ◽  
Author(s):  
Mawadda Alnaeeli ◽  
Li Wang ◽  
Barbora Piknova ◽  
Heather Rogers ◽  
Xiaoxia Li ◽  
...  

Erythropoietin is known as the requisite cytokine for red blood cell production. Its receptor, expressed at a high level on erythroid progenitor/precursor cells, is also found on endothelial, neural, and other cell types. Erythropoietin and erythropoietin receptor expression in the developing and adult brain suggest their possible involvement in neurodevelopment and neuroprotection. During ischemic stress, erythropoietin, which is hypoxia inducible, can contribute to brain homeostasis by increasing red blood cell production to increase the blood oxygen carrying capacity, stimulate nitric oxide production to modulate blood flow and contribute to the neurovascular response, or act directly on neural cells to provide neuroprotection as demonstrated in culture and animal models. Clinical studies of erythropoietin treatment in stroke and other diseases provide insight on safety and potential adverse effects and underscore the potential pleiotropic activity of erythropoietin. Herein, we summarize the roles of EPO and its receptor in the developing and adult brain during health and disease, providing first a brief overview of the well-established EPO biology and signaling, its hypoxic regulation, and role in erythropoiesis.


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