Case Report: A Rare Case of Lupus Nephritis Associated With Mantle Cell Lymphoma

In this research, we described a very rare case of secondary lupus nephritis associated with B-cell lymphoma. An 84-year-old man was hospitalized at our institute for lower extremity edema persisting for over 2 months. He was diagnosed with systemic lupus erythematosus based on clinical and laboratory criteria, which showed impaired renal function and nephrotic syndrome with predominant hematuria. Renal biopsy showed IV+V lupus nephritis with highly infiltrated lymphoid cells in the kidney. Secondary lupus nephritis was suspected based on the possible pathogenesis of glomerular injury due to mantle cell lymphoma. Low-dose dexamethasone, rituximab, and lenalidomide were immediately started on the patient, and his renal function was improved after the first cycle of chemotherapy.

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Primary mantle cell lymphoma complicated with cutaneous diffuse large B-cell lymphoma, leg type: a rare case report of composite non-Hodgkin lymphoma in different organs

10.21203/rs.3.rs-70686/v1 ◽

2020 ◽

Author(s):

Yanfeng Jiang ◽

Zhiming Zeng ◽

Lihua Yang ◽

Jie Zeng ◽

Fengyan Qin ◽

...

Keyword(s):

B Cell ◽

Mantle Cell Lymphoma ◽

Hodgkin Lymphoma ◽

Rare Case ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Non Hodgkin Lymphoma ◽

Large B Cell Lymphoma ◽

Mantle Cell ◽

Large B Cell

Abstract Background Composite lymphomas (CLs) are a kind of rare disease that two distinct categories of lymphomas occur in the same patient. Histologically, composite lymphomas can be composed of a Hodgkin’s lymphoma and a non-Hodgkin lymphoma or two distinct non-Hodgkin lymphomas. So far, most of the cases have been reported to occur in a single anatomical site or mass. Case presentation: A 61-year-old man without any B-type symptoms complained of an enlarging mass in the abdomen for one month. A 10 × 10 cm abdominal mass could be touched in the hypogastric region. Through pathological biopsy, mantle cell lymphoma can be diagnosed. After one cycle chemotherapy regimen of FCD, red rashes and blisters came out on the patient's right lower extremity. Cutaneous diffuse large B-cell lymphoma (DLBCL) was diagnosed by skin biopsy. In this report, we describe a case of composite lymphoma occurring in different organs, which consisted of primary mantle cell lymphoma (MCL) and cutaneous DLBCL, leg type. The patient then received a series of chemotherapy regimens without rituximab then achieved partial response (PR). Conclusions To our knowledge, this is a rare case of CLs occurring in different anatomic sites that were treated by chemotherapy and achieved PR. As we learn more about the mechanisms and treatment of CLs, we look forward to more treatment options in the future for patients to give them a better prognosis.

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Aggressive Cyclin D1 Negative Blastoid Variant Mantle Cell Lymphoma—A Case Report

International Journal of Surgical Pathology ◽

10.1177/10668969211027409 ◽

2021 ◽

pp. 106689692110274

Author(s):

Lavina Loungani ◽

Rajesh Mundhe ◽

Roshan Chinoy

Keyword(s):

Lymph Node ◽

B Cell ◽

Cyclin D1 ◽

Mantle Cell Lymphoma ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Lymphoid Cells ◽

Proliferation Index ◽

Axillary Lymph ◽

Mantle Cell

A 68-year-old male presents with generalized lymphadenopathy and fever of short duration. Axillary lymph node excision was performed and was sent for histopathological evaluation. Microscopic evaluation of the submitted lymph node revealed diffuse proliferation of intermediate-sized atypical lymphoid cells with round nuclei, irregular membranes, finely dispersed chromatin, and inconspicuous nucleoli. Mitotic figures were frequently seen. Immunohistochemical evaluation revealed diffuse expression of CD20, CD5, CD10, B-cell lymphoma 2 (Bcl2), and B-cell lymphoma 6 (Bcl6). Atypical lymphoid cells were negative for cyclin D1; however, showed diffuse and strong nuclear expression of SOX11. MIB1 proliferation index was high (Ki67: 90%-95%). Based on morphological features and immunohistochemical findings a diagnosis of “cyclin D1 negative aggressive blastoid variant of mantle cell lymphoma (MCL)” was offered. The classic morphology of MCL is seen in 90% of cases, while the remaining (∼10%) are considered as variants. A blastoid variant is an aggressive subtype that can lack expression of CD5 as well as cyclin D1, but instead expresses CD10, Bcl6, and CD23. SOX11 expression is seen in 90% cases of MCL and in almost 100% cases of cyclin D1 negative MCL. The current case highlights the unusual morphologic and aggressive variant of MCL and a significant role of SOX11 in its diagnosis.

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A Rare Case of Multiple Lymphomatous Polyposis With Widespread Involvement of the Gastrointestinal Tract

Archives of Pathology & Laboratory Medicine ◽

10.5858/2003-127-1028-arcoml ◽

2003 ◽

Vol 127 (8) ◽

pp. 1028-1030

Author(s):

JoséM. Remes-Troche ◽

Jazmín De-Anda ◽

Víctor Ochoa ◽

Rafael Barreto-Zuñiga ◽

Julián Arista-Nasr ◽

...

Keyword(s):

Rare Case ◽

Chemotherapy Regimen ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Malignant Cells ◽

Gi Tract ◽

Diffuse Abdominal Pain ◽

Mantle Cell ◽

Lower Gi Bleeding ◽

Multiple Lymphomatous Polyposis

Abstract Multiple lymphomatous polyposis (MLP) is an uncommon type of primary non-Hodgkin gastrointestinal (GI) B-cell lymphoma characterized by the presence of multiple polyps along the GI tract. Malignant cells of MLP have mantle cell characteristics and thus are considered to be the counterpart of the mantle cell lymphoma (MCL) in the GI tract. Since 1961, no more than 70 well-documented cases have been published. We report the case of 53-year-old man diagnosed as having MLP. The patient presented with diffuse abdominal pain, chronic lower GI bleeding, peripheral lymphadenopathy, and weight loss. The lymphomatous polyps extended from the esophagus to the rectum, with bone marrow infiltration. Immunohistologic findings were characteristic of MCL. The patient was treated with a combined cyclophosphamide, vincristine, and prednisone chemotherapy regimen, resulting in a partial response.

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Prospective clinical study of R-CMD therapy for indolent B cell lymphoma and mantle cell lymphoma from the Hokuriku Hematology Oncology Study Group

Medical Oncology ◽

10.1007/s12032-015-0677-9 ◽

2015 ◽

Vol 32 (9) ◽

Author(s):

Tomoyuki Sakai ◽

Yasufumi Masaki ◽

Nozomi Otsuki ◽

Ippei Sakamaki ◽

Shinji Kishi ◽

...

Keyword(s):

Clinical Study ◽

B Cell ◽

Mantle Cell Lymphoma ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Prospective Clinical Study ◽

Study Group ◽

Mantle Cell

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Mantle Cell Lymphoma

Archives of Pathology & Laboratory Medicine ◽

10.5858/1999-123-1182-mcl ◽

1999 ◽

Vol 123 (12) ◽

pp. 1182-1188 ◽

Cited By ~ 1

Author(s):

Rebecca C. Hankin ◽

Susan V. Hunter

Keyword(s):

Polymerase Chain Reaction ◽

B Cell ◽

Mantle Cell Lymphoma ◽

Diagnostic Tests ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Molecular Diagnostic ◽

Chain Reaction ◽

Mantle Cell ◽

Polymerase Chain

Abstract Objective.—This article summarizes the most useful ancillary immunohistochemical and molecular assays for use in the diagnosis of mantle cell lymphoma. Data Sources.—The English language literature was surveyed, with an emphasis on recent publications, for articles presenting key advances in the molecular characterization of mantle cell lymphomas and for series of cases testing the utility of molecular diagnostic tests. The authors' series of 26 small B-cell lymphomas, analyzed for the cyclin D1 protein by paraffin immunohistochemistry and for t(11;14) by polymerase chain reaction, is included. Conclusions.—Mantle cell lymphoma, a B-cell lymphoma now recognized in the 1994 Revised European-American Classification of Lymphoid Neoplasms (REAL) classification, is a relatively aggressive lymphoma with a poor prognosis. Its characteristic t(11;14)(q13;q32) translocation has a role in oncogenesis and has been exploited for molecular diagnostic tests, but these tests vary in sensitivity, specificity, and ease of use. Improved immunohistochemical tests are sufficient to confirm the diagnosis in most cases. Conventional cytogenetics and molecular diagnostic tests for t(11;14)—Southern blot and polymerase chain reaction analysis—may be helpful in selected cases, but are laborious or of limited sensitivity. Other methods, such as fluorescence in situ hybridization, need further development to provide faster, more sensitive diagnosis.

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