scholarly journals Enhancing Working Memory Based on Mismatch Negativity Neurofeedback in Subjective Cognitive Decline Patients: A Preliminary Study

2020 ◽  
Vol 12 ◽  
Author(s):  
Guangying Pei ◽  
Ruoshui Yang ◽  
Zhongyan Shi ◽  
Guoxin Guo ◽  
Shujie Wang ◽  
...  
Keyword(s):  
Working Memory ◽  
Cognitive Decline ◽  
Mismatch Negativity ◽  
Subjective Cognitive Decline ◽  
Preliminary Study

Is the Discrimination of Subjective Cognitive Decline from Cognitively Healthy Adulthood and Mild Cognitive Impairment Possible? A Pilot Study Utilizing the R4Alz Battery

2020 ◽  
Vol 77 (2) ◽  
pp. 715-732
Author(s):  
Eleni Poptsi ◽  
Despina Moraitou ◽  
Emmanouil Tsardoulias ◽  
Andreas L. Symeonidisd ◽  
Magda Tsolaki
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Control ◽  
Cognitive Decline ◽  
Neurocognitive Disorders ◽  
Community Dwelling ◽  
Subjective Cognitive Decline ◽  
Working Memory Updating

Background: The early diagnosis of neurocognitive disorders before the symptoms’ onset is the ultimate goal of the scientific community. REMEDES for Alzheimer (R4Alz) is a battery, designed for assessing cognitive control abilities in people with minor and major neurocognitive disorders. Objective: To investigate whether the R4Alz battery’s tasks differentiate subjective cognitive decline (SCD) from cognitively healthy adults (CHA) and mild cognitive impairment (MCI). Methods: The R4Alz battery was administered to 175 Greek adults, categorized in five groups a) healthy young adults (HYA; n = 42), b) healthy middle-aged adults (HMaA; n = 33), c) healthy older adults (HOA; n = 14), d) community-dwelling older adults with SCD (n = 34), and e) people with MCI (n = 52). Results: Between the seven R4Alz subtasks, four showcased the best results for differentiating HOA from SCD: the working memory updating (WMCUT-S3), the inhibition and switching subtask (ICT/RST-S1&S2), the failure sets (FS) of the ICT/RST-S1&S2, and the cognitive flexibility subtask (ICT/RST-S3). The total score of the four R4Alz subtasks (R4AlzTot4) leads to an excellent discrimination among SCD and healthy adulthood, and to fare discrimination among SCD and MCI. Conclusion: The R4Alz battery is a novel approach regarding the neuropsychological assessment of people with SCD, since it can very well assist toward discriminating SCD from HOA. The R4Alz is able to measure decline of specific cognitive control abilities - namely of working memory updating, and complex executive functions - which seem to be the neuropsychological substrate of cognitive complaints in community dwelling adults of advancing age.

scholarly journals ASSOCIATION BETWEEN SUBJECTIVE AND OBJECTIVE COGNITIVE FUNCTION IN CHINA

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S205-S205
Author(s):  
Bada Kang ◽  
Hanzhang Xu ◽  
Eleanor S McConnell ◽  
Bei Wu
Keyword(s):  
Working Memory ◽  
Cognitive Function ◽  
Cognitive Decline ◽  
Verbal Fluency ◽  
Digit Span ◽  
World Health ◽  
Subjective Cognitive Decline ◽  
Related Factors ◽  
Memory Decline ◽  
Subjective Cognitive Function

Abstract Although subjective cognitive decline is considered as a potential symptomatic indicator of cognitive decline, little is known regarding the relationships in older adults in China. Using the World Health Organization Study on global AGEing and adult health (SAGE) Wave 1 data, we examined the association between subjective cognitive function, perceived memory decline, and objective cognitive function among adults aged 50 or older (N=13,367) in China. Objective cognitive function was measured by immediate and delayed recall test, digit span test, and verbal fluency test. Multivariate linear regression models were used to account for sociodemographic, psychosocial, and health-related factors. We found worse subjective cognitive function was associated with poorer working memory and verbal fluency. Greater perceived memory decline was also associated with poorer working memory but not with verbal fluency. Psychosocial factors including social cohesion and social support attenuated the relationships between subjective cognitive function, perceived memory decline, and objective cognitive performance.

Spatiotemporal Oscillatory Patterns During Working Memory Maintenance in Mild Cognitive Impairment and Subjective Cognitive Decline

2019 ◽  
Vol 30 (01) ◽  
pp. 1950019
Author(s):  
N. Serrano ◽  
D. López-Sanz ◽  
R. Bruña ◽  
P. Garcés ◽  
I. C. Rodríguez-Rojo ◽  
...  
Keyword(s):  
Working Memory ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Decline ◽  
Subjective Cognitive Decline ◽  
Alpha Power ◽  
Time Frequency ◽  
Neuronal Processes ◽  
Cortical Regions ◽  
Local Synchronization

Working memory (WM) is a crucial cognitive process and its disruption is among the earliest symptoms of Alzheimer’s disease. While alterations of the neuronal processes underlying WM have been evidenced in mild cognitive impairment (MCI), scarce literature is available in subjective cognitive decline (SCD). We used magnetoencephalography during a WM task performed by MCI [Formula: see text], SCD [Formula: see text] and healthy elders [Formula: see text] to examine group differences during the maintenance period (0–4000[Formula: see text]ms). Data were analyzed using time–frequency analysis and significant oscillatory differences were localized at the source level. Our results indicated significant differences between groups, mainly during the early maintenance (250–1250[Formula: see text]ms) in the theta, alpha and beta bands and in the late maintenance (2750–3750[Formula: see text]ms) in the theta band. MCI showed lower local synchronization in fronto-temporal cortical regions in the early theta–alpha window relative to controls [Formula: see text] and SCD [Formula: see text], and in the late theta window relative to controls [Formula: see text] and SCD [Formula: see text]. Early theta–alpha power was significantly correlated with memory scores [Formula: see text] and late theta power was correlated with task performance [Formula: see text] and functional activity scores [Formula: see text]. In the early beta window, MCI showed reduced power in temporo-posterior regions relative to controls [Formula: see text] and SCD [Formula: see text]. Our results may suggest that these alterations would reflect that memory-related networks are damaged.

scholarly journals Aberrant memory system connectivity and working memory performance in subjective cognitive decline

NeuroImage ◽  
2019 ◽  
Vol 185 ◽  
pp. 556-564 ◽  
Author(s):  
Raymond P. Viviano ◽  
Jessica M. Hayes ◽  
Patrick J. Pruitt ◽  
Zachary J. Fernandez ◽  
Sanneke van Rooden ◽  
...  
Keyword(s):  
Working Memory ◽  
Cognitive Decline ◽  
Memory Performance ◽  
Memory System ◽  
Subjective Cognitive Decline

scholarly journals P3-409: WORKING MEMORY TASK-BASED FMRI IN SUBJECTIVE COGNITIVE DECLINE: EVIDENCE FOR NEURAL COMPENSATION

2019 ◽  
Vol 15 ◽  
pp. P1111-P1111
Author(s):  
Jian Zhu ◽  
Shannon L. Risacher ◽  
John D. West ◽  
Rachael Deardorff ◽  
Eileen F. Tallman ◽  
...  
Keyword(s):  
Working Memory ◽  
Cognitive Decline ◽  
Memory Task ◽  
Subjective Cognitive Decline ◽  
Neural Compensation

Human Event-Related Potentials to Higher-Order Acoustic Spatial Changes

2002 ◽  
Vol 16 (2) ◽  
pp. 114-118 ◽  
Author(s):  
Timo Ruusuvirta ◽  
Heikki Hämäläinen
Keyword(s):  
Working Memory ◽  
Mismatch Negativity ◽  
Spatial Information ◽  
Free Field ◽  
Event Related Potentials ◽  
Negative Polarity ◽  
Positive Polarity ◽  
Spatial Changes ◽  
Related Potentials ◽  
Human Event

Abstract Human event-related potentials (ERPs) to a tone continuously alternating between its two spatial loci of origin (middle-standards, left-standards), to repetitions of left-standards (oddball-deviants), and to the tones originally representing these repetitions presented alone (alone-deviants) were recorded in free-field conditions. During the recordings (Fz, Cz, Pz, M1, and M2 referenced to nose), the subjects watched a silent movie. Oddball-deviants elicited a spatially diffuse two-peaked deflection of positive polarity. It differed from a deflection elicited by left-standards and commenced earlier than a prominent deflection of negative polarity (N1) elicited by alone-deviants. The results are discussed in the context of the mismatch negativity (MMN) and previous findings of dissociation between spatial and non-spatial information in auditory working memory.

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