scholarly journals Altered Regional Cerebral Blood Flow and Brain Function Across the Alzheimer's Disease Spectrum: A Potential Biomarker

2021 ◽  
Vol 13 ◽  
Author(s):  
Qianqian Zhang ◽  
Qing Wang ◽  
Cancan He ◽  
Dandan Fan ◽  
Yao Zhu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Brain Activity ◽  
Posterior Cingulate Cortex ◽  
Regional Cerebral Blood ◽  
Posterior Cingulate ◽  
Disease Spectrum

Objective: To investigate variation in the characteristics of regional cerebral blood flow (rCBF), brain activity, and intrinsic functional connectivity (FC) across the Alzheimer's disease spectrum (ADS).Methods: The study recruited 20 individuals in each of the following categories: Alzheimer's disease (AD), mild cognitive impairment (MCI), subjective cognitive decline (SCD), and healthy control (HC). All participants completed the 3.0T resting-state functional MRI (rs-fMRI) and arterial spin labeling scans in addition to neuropsychological tests. Additionally, the normalized CBF, regional homogeneity (ReHo), and amplitude of low-frequency fluctuation (ALFF) of individual subjects were compared in the ADS. Moreover, the changes in intrinsic FC were investigated across the ADS using the abnormal rCBF regions as seeds and behavioral correlations. Finally, a support-vector classifier model of machine learning was used to distinguish individuals with ADS from HC.Results: Compared to the HC subjects, patients with AD showed the poorest level of rCBF in the left precuneus (LPCUN) and right middle frontal gyrus (RMFG) among all participants. In addition, there was a significant decrease in the ALFF in the bilateral posterior cingulate cortex (PCC) and ReHo in the right PCC. Moreover, RMFG- and LPCUN-based FC analysis revealed that the altered FCs were primarily located in the posterior brain regions. Finally, a combination of altered rCBF, ALFF, and ReHo in posterior cingulate cortex/precuneus (PCC/PCUN) showed a better ability to differentiate ADS from HC, AD from SCD and MCI, but not MCI from SCD.Conclusions: The study demonstrated the significance of an altered rCBF and brain activity in the early stages of ADS. These findings, therefore, present a potential diagnostic neuroimaging-based biomarker in ADS. Additionally, the study provides a better understanding of the pathophysiology of AD.

scholarly journals Regional cerebral blood flow decline can predict atrophy in Alzheimer’s disease spectrum

2021 ◽  
Author(s):  
Fardin Nabizadeh ◽  
Mohammad Reza Rostami ◽  
Mohammad Balabandian
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Structural Changes ◽  
Regional Cerebral Blood ◽  
Mri Findings ◽  
Disease Spectrum ◽  
Subcortical Volume

Abstract According to MRI findings, brain atrophy and structural changes play important roles as valid biomarkers for Alzheimer’s Disease (AD) and can support the clinical diagnosis of AD. A decline in the regional cerebral blood flow (rCBF) is believed to be one of the initial changes in the AD continuum. Some studies revealed an association between the amyloid beta (Aβ) and rCBF pattern and suggested that reduced rCBF is an early consequence of neural death prior to considerable grey matter loss. Therefore, in the present study, we investigated the association between rCBF and brain structural changes in three groups of individuals, that is, control (CN), MCI, and AD groups. Our findings revealed a wide spread significant correlation between the rCBF and structural changes, including cortical volume, subcortical volume, surface area, and thickness in all groups after adjusting for age, sex, and APOE genotyping status. According to the present results, CBF might predict future structural changes and cause neurodegeneration associated with AD development, regardless of Aβ or tau accumulation.

scholarly journals Regional cerebral blood flow decline can predict atrophy in Alzheimer’s disease spectrum

2021 ◽  
Author(s):  
Fardin Nabizadeh ◽  
Mohammad Reza Rostami ◽  
Mohammad Balabandian
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Structural Changes ◽  
Executive Dysfunction ◽  
Regional Cerebral Blood ◽  
Disease Spectrum ◽  
Personality Changes

Abstract Alzheimer’s disease (AD) is a neurodegenerative disease characterized by symptoms such as dementia, personality changes, and executive dysfunction. Brain atrophy and structural changes based on the MRI play an important role as a valid biomarker of AD and can support the clinical diagnosis of AD. The decline in the regional cerebral blood flow (rCBF) is believed to be among the first changes in Alzheimer’s continuum. The reason for this reduction in cerebral blood flow is not fully understood yet. Previous studies revealed the association between amyloid-beta and rCBF pattern and suggested that reduced rCBF is an early consequence of neural death and is prior to the considerable grey matter loss. In this study we investigated the association between rCBF and brain structural changes in three different groups of subjects consisted of control (CN), MCI, and AD groups. Our findings revealed a significant correlation between rCBF and structural changes including cortical volume, subcortical volume, surface area, and thickness in all groups after adjusting for age, sex, and APOE genotyping status. As our investigation, cerebral blood flow as measured by ASL-MRI might independent from Aβ and tau accumulation predict future structural changes and causes neurodegeneration in relation to AD development.

scholarly journals Regional cerebral blood flow decline can predict atrophy in Alzheimer’s disease spectrum

2021 ◽  
Author(s):  
Fardin Nabizadeh ◽  
Mohammad Reza Rostami ◽  
Mohammad Balabandian
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Structural Changes ◽  
Regional Cerebral Blood ◽  
Mri Findings ◽  
Disease Spectrum ◽  
Subcortical Volume

Abstract According to MRI findings, brain atrophy and structural changes play important roles as valid biomarkers for Alzheimer’s Disease (AD) and can support the clinical diagnosis of AD. A decline in the regional cerebral blood flow (rCBF) is believed to be one of the initial changes in the AD continuum. Some studies revealed an association between the amyloid beta (Aβ) and rCBF pattern and suggested that reduced rCBF is an early consequence of neural death prior to considerable grey matter loss. Therefore, in the present study, we investigated the association between rCBF and brain structural changes in three groups of individuals, that is, control (CN), MCI, and AD groups. Our findings revealed a wide spread significant correlation between the rCBF and structural changes, including cortical volume, subcortical volume, surface area, and thickness in all groups after adjusting for age, sex, and APOE genotyping status. According to the present results, CBF might predict future structural changes and cause neurodegeneration associated with AD development, regardless of Aβ or tau accumulation.

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