A Temporal Activity of CA1 Neurons Underlying Short-Term Memory for Social Recognition Altered in PTEN Mouse Models of Autism Spectrum Disorder

Memory-guided social recognition identifies someone from previous encounters or experiences, but the mechanisms of social memory remain unclear. Here, we find that a short-term memory from experiencing a stranger mouse lasting under 30 min interval is essential for subsequent social recognition in mice, but that interval prolonged to hours by replacing the stranger mouse with a familiar littermate. Optogenetic silencing of dorsal CA1 neuronal activity during trials or inter-trial intervals disrupted short-term memory-guided social recognition, without affecting the ability of being sociable or long-term memory-guided social recognition. Postnatal knockdown or knockout of autism spectrum disorder (ASD)-associated phosphatase and tensin homolog (PTEN) gene in dorsal hippocampal CA1 similarly impaired neuronal firing rate in vitro and altered firing pattern during social recognition. These PTEN mice showed deficits in social recognition with stranger mouse rather than littermate and exhibited impairment in T-maze spontaneous alternation task for testing short-term spatial memory. Thus, we suggest that a temporal activity of dorsal CA1 neurons may underlie formation of short-term memory to be critical for organizing subsequent social recognition but that is possibly disrupted in ASD.

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Application of Skeleton Data and Long Short-Term Memory in Action Recognition of Children with Autism Spectrum Disorder

Sensors ◽

10.3390/s21020411 ◽

2021 ◽

Vol 21 (2) ◽

pp. 411

Author(s):

Yunkai Zhang ◽

Yinghong Tian ◽

Pingyi Wu ◽

Dongfan Chen

Keyword(s):

Autism Spectrum Disorder ◽

Action Recognition ◽

Short Term Memory ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Short Term ◽

Term Memory ◽

Clinical Observations ◽

The Neural Network ◽

Long Short Term Memory

The recognition of stereotyped action is one of the core diagnostic criteria of Autism Spectrum Disorder (ASD). However, it mainly relies on parent interviews and clinical observations, which lead to a long diagnosis cycle and prevents the ASD children from timely treatment. To speed up the recognition process of stereotyped actions, a method based on skeleton data and Long Short-Term Memory (LSTM) is proposed in this paper. In the first stage of our method, the OpenPose algorithm is used to obtain the initial skeleton data from the video of ASD children. Furthermore, four denoising methods are proposed to eliminate the noise of the initial skeleton data. In the second stage, we track multiple ASD children in the same scene by matching distance between current skeletons and previous skeletons. In the last stage, the neural network based on LSTM is proposed to classify the ASD children’s actions. The performed experiments show that our proposed method is effective for ASD children’s action recognition. Compared to the previous traditional schemes, our scheme has higher accuracy and is almost non-invasive for ASD children.

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Intact inner speech use in autism spectrum disorder: evidence from a short-term memory task

Journal of Child Psychology and Psychiatry ◽

10.1111/j.1469-7610.2007.01836.x ◽

2008 ◽

Vol 49 (1) ◽

pp. 51-58 ◽

Cited By ~ 37

Author(s):

David Williams ◽

Francesca Happé ◽

Christopher Jarrold

Keyword(s):

Autism Spectrum Disorder ◽

Short Term Memory ◽

Memory Task ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Inner Speech ◽

Short Term ◽

Term Memory

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Inner speech is used to mediate short-term memory, but not planning, among intellectually high-functioning adults with autism spectrum disorder

Development and Psychopathology ◽

10.1017/s0954579411000794 ◽

2012 ◽

Vol 24 (1) ◽

pp. 225-239 ◽

Cited By ~ 42

Author(s):

David M. Williams ◽

Dermot M. Bowler ◽

Christopher Jarrold

Keyword(s):

Autism Spectrum Disorder ◽

Articulatory Suppression ◽

Short Term Memory ◽

Recall Performance ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Inner Speech ◽

Short Term ◽

Order Problem ◽

Term Memory

AbstractEvidence regarding the use of inner speech by individuals with autism spectrum disorder (ASD) is equivocal. To clarify this issue, the current study employed multiple techniques and tasks used across several previous studies. In Experiment 1, participants with and without ASD showed highly similar patterns and levels of serial recall for visually presented stimuli. Both groups were significantly affected by the phonological similarity of items to be recalled, indicating that visual material was spontaneously recoded into a verbal form. Confirming that short-term memory is typically verbally mediated among the majority of people with ASD, recall performance among both groups declined substantially when inner speech use was prevented by the imposition of articulatory suppression during the presentation of stimuli. In Experiment 2, planning performance on a tower of London task was substantially detrimentally affected by articulatory suppression among comparison participants, but not among participants with ASD. This suggests that planning is not verbally mediated in ASD. It is important that the extent to which articulatory suppression affected planning among participants with ASD was uniquely associated with the degree of their observed and self-reported communication impairments. This confirms a link between interpersonal communication with others and intrapersonal communication with self as a means of higher order problem solving.

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Enhancement of Short-Term Memory by Methyl-6-(Phenylethynyl)-Pyridine in the BTBR T+tf/J Mouse Model of Autism Spectrum Disorder

Endocrinology and Metabolism ◽

10.3803/enm.2015.30.1.98 ◽

2015 ◽

Vol 30 (1) ◽

pp. 98 ◽

Cited By ~ 8

Author(s):

Haijie Yang ◽

Sung-Oh Huh ◽

Jae Seung Hong

Keyword(s):

Autism Spectrum Disorder ◽

Mouse Model ◽

Short Term Memory ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Short Term ◽

Term Memory

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Short-term memory in autism spectrum disorder.

Journal of Abnormal Psychology ◽

10.1037/a0022298 ◽

2011 ◽

Vol 120 (1) ◽

pp. 247-252 ◽

Cited By ~ 43

Author(s):

Marie Poirier ◽

Jonathan S. Martin ◽

Sebastian B. Gaigg ◽

Dermot M. Bowler

Keyword(s):

Autism Spectrum Disorder ◽

Short Term Memory ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Short Term ◽

Term Memory

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Verbal Short-Term Memory as Language Predictor in Children with Autism Spectrum Disorder

Journal of Behavioral and Brain Science ◽

10.4236/jbbs.2020.10513 ◽

2020 ◽

Vol 10 (05) ◽

pp. 200-219

Author(s):

Ioanna Talli

Keyword(s):

Autism Spectrum Disorder ◽

Short Term Memory ◽

Children With Autism ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Short Term ◽

Term Memory

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Short‐Term Memory Span and Cross‐Modality Integration in Younger and Older Adults With and Without Autism Spectrum Disorder

Autism Research ◽

10.1002/aur.2387 ◽

2020 ◽

Vol 13 (11) ◽

pp. 1970-1984

Author(s):

Melanie Ring ◽

Bérengère Guillery‐Girard ◽

Peggy Quinette ◽

Sebastian B. Gaigg ◽

Dermot M. Bowler

Keyword(s):

Older Adults ◽

Autism Spectrum Disorder ◽

Short Term Memory ◽

Memory Span ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Short Term ◽

Term Memory

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Visuospatial Short-Term Memory Explains Deficits in Tower Task Planning in High-Functioning Children with Autism Spectrum Disorder

Child Neuropsychology ◽

10.1080/09297040903559648 ◽

2010 ◽

Vol 16 (3) ◽

pp. 229-241 ◽

Cited By ~ 21

Author(s):

Katharina Zinke ◽

Eva Fries ◽

Mareike Altgassen ◽

Clemens Kirschbaum ◽

Lucia Dettenborn ◽

...

Keyword(s):

Autism Spectrum Disorder ◽

Short Term Memory ◽

Children With Autism ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Task Planning ◽

Short Term ◽

Term Memory ◽

High Functioning

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AppPECS: Mobile Application for Children with Autism Spectrum Disorder

ECORFAN Journal Spain ◽

10.35429/ejs.2019.10.6.27.38 ◽

2019 ◽

pp. 27-38

Author(s):

Carlos Enríquez-Ramírez ◽

Juan Carlos Cruz-Reséndiz ◽

Miriam Olvera-Cueyar ◽

Roberto Arturo Sánchez-Herrera

Keyword(s):

Autism Spectrum Disorder ◽

Mobile Applications ◽

Mobile Application ◽

Short Term Memory ◽

Educational Games ◽

Children With Autism ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Short Term ◽

Learning Development

The study of treatments for children with autism and interventions through educational games is growing because researchers have seen an acceptance by users with autism spectrum disorder in this type of applications. Allowing this type of users to acquire and develop new skills such as digital, the development of writing through the use of the keyboard, as a means of communication and a mechanism of reinforcement in sociable aspects. Taking into account the benefits of using games through mobile applications in the treatment of targeted therapies in children with autism spectrum disorder, a mobile application has been developed to obtain an experience that interactively stimulates children for the purpose of Reinforce areas of learning development, such as repetition of activities (socialization), concentration, reinforcement of short-term memory, order and development of kinesthetic skills through the use of digitization. This project was applied in the Unidad de Servicios de Apoyo a la Escuela Regular No. 21 (USAER) instance of Special Education, dependent on the Secretaría de Educación Pública de Hidalgo.

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