scholarly journals Cerebrovascular Function in Hormonal Migraine: An Exploratory Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Jemima S. A. Dzator ◽  
Peter R. C. Howe ◽  
Lyn R. Griffiths ◽  
Kirsten G. Coupland ◽  
Rachel H. X. Wong
Keyword(s):  
Quality Of Life ◽  
Blood Flow ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Neurovascular Coupling ◽  
Cognitive Stimulation ◽  
Cerebrovascular Function ◽  
Increased Risk ◽  
The Right

Background: Migraineurs, particularly young premenopausal women, are at increased risk of cerebrovascular disease; however, there is currently limited evidence as to whether hormonal migraine is associated with poor cerebrovascular function.Objectives: The objectives of this study were to: (1) investigate the potential association of cerebrovascular function with hormonal migraine and (2) determine whether abnormalities of cerebrovascular function in hormonal migraineurs are associated with migraine-related disability and/or quality of life.Method: A cross-sectional study was undertaken in 50 hormonal migraineurs (mean age: 38.7 ± 1.2 years) and 29 controls (mean age: 35.6 ± 1.8 years). Data were collected at a single point in time from all participants during the inter-ictal period when they were free from migraine and not menstruating. Transcranial Doppler ultrasound was used to measure resting blood flow velocity and cerebrovascular responsiveness (CVR) to hypercapnia and cognitive stimulation (neurovascular coupling) in the left and right middle cerebral artery (MCA). Additionally, hormonal migraineurs completed three questionnaires to assess migraine-related disability and quality of life as well as migraine frequency and intensity: Headache Impact Test-6™, Migraine-Specific Quality of Life and Migraine Disability Assessment.Results: Hormonal migraineurs had lower resting mean blood flow velocity (MBFV) (P = 0.009) and neurovascular coupling during cognitive stimulation (P = 0.010) in the left MCA than controls. No such differences were found in the right MCA. Additionally, heart rate (P = 0.004) was higher in hormonal migraineurs than controls. However, no differences in CVR to hypercapnia were found between hormonal migraineurs and controls. Multi-variate analysis revealed age to be a significant (P = 0.012) predictor of MBFV in the left MCA. Negative correlations between headache frequency and CVR to hypercapnia in the left (P = 0.026) and right MCA (P = 0.044) were found. Additionally, negative correlations between neurovascular coupling during the 2-Back 1.5 s task in the right MCA and the MSQoL emotional (P = 0.013) and role-function restrictive (P = 0.039) domains were found.Conclusions: This is the first study to show that hormonal migraineurs have poorer cerebrovascular function, as represented by lower resting MBFV and impaired neurovascular coupling in the left MCA. Future studies should investigate whether improving cerebrovascular function can prevent hormonal migraine and improve quality of life.Clinical Trial Registration: ACTRN12618001230246.

Alterations in cerebral autoregulation and cerebral blood flow velocity during acute hypoxia: rest and exercise

2007 ◽  
Vol 292 (2) ◽  
pp. H976-H983 ◽  
Author(s):  
Philip N. Ainslie ◽  
Alice Barach ◽  
Carissa Murrell ◽  
Mike Hamlin ◽  
John Hellemans ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Cerebral Autoregulation ◽  
Cerebral Oxygenation ◽  
Cerebral Blood Flow Velocity ◽  
Arterial Blood ◽  
Cerebrovascular Function ◽  
Hypoxic Exercise

We examined the relationship between changes in cardiorespiratory and cerebrovascular function in 14 healthy volunteers with and without hypoxia [arterial O2 saturation (SaO2) ∼80%] at rest and during 60–70% maximal oxygen uptake steady-state cycling exercise. During all procedures, ventilation, end-tidal gases, heart rate (HR), arterial blood pressure (BP; Finometer) cardiac output (Modelflow), muscle and cerebral oxygenation (near-infrared spectroscopy), and middle cerebral artery blood flow velocity (MCAV; transcranial Doppler ultrasound) were measured continuously. The effect of hypoxia on dynamic cerebral autoregulation was assessed with transfer function gain and phase shift in mean BP and MCAV. At rest, hypoxia resulted in increases in ventilation, progressive hypocapnia, and general sympathoexcitation (i.e., elevated HR and cardiac output); these responses were more marked during hypoxic exercise ( P < 0.05 vs. rest) and were also reflected in elevation of the slopes of the linear regressions of ventilation, HR, and cardiac output with SaO2 ( P < 0.05 vs. rest). MCAV was maintained during hypoxic exercise, despite marked hypocapnia (44.1 ± 2.9 to 36.3 ± 4.2 Torr; P < 0.05). Conversely, hypoxia both at rest and during exercise decreased cerebral oxygenation compared with muscle. The low-frequency phase between MCAV and mean BP was lowered during hypoxic exercise, indicating impairment in cerebral autoregulation. These data indicate that increases in cerebral neurogenic activity and/or sympathoexcitation during hypoxic exercise can potentially outbalance the hypocapnia-induced lowering of MCAV. Despite maintaining MCAV, such hypoxic exercise can potentially compromise cerebral autoregulation and oxygenation.

Measurement of blood flow velocity using a method that simultaneously provides data on the activity of the circulation of the right and left heart

1936 ◽  
Vol 32 (12) ◽  
pp. 1499-1499
Author(s):  
A. Gilman
Keyword(s):  
Blood Flow ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Left Heart ◽  
The Right

Measurement of blood flow velocity using a method that simultaneously provides data on the activity of the circulation of the right and left heart

Influence of Smoking Cigarettes on Cerebral Blood Flow Parameters

2013 ◽  
Vol 17 (1) ◽  
pp. 8-12 ◽  
Author(s):  
Jan Kochanowicz ◽  
Jolanta Lewko ◽  
Robert Rutkowski ◽  
Grzegorz Turek ◽  
Andrzej Sieskiewicz ◽  
...  
Keyword(s):  
Blood Flow ◽  
Flow Velocity ◽  
Cerebral Artery ◽  
Blood Flow Velocity ◽  
Cerebral Arteries ◽  
Velocity Ratio ◽  
Peak Systolic Velocity ◽  
Flow Parameters ◽  
Diastolic Velocity ◽  
Increased Risk

Introduction: While chronic cigarette smoking can lead to increased risk of stroke, the acute effects of smoking have not been established. We studied the changes in blood flow parameters in the major cerebral arteries caused by smoking one cigarette. Method: Using transcranial color-coded sonography (TCCS), we studied the anterior cerebral artery (ACA), middle cerebral artery (MCA), posterior cerebral artery (PCA), and the internal carotid artery (ICA) of 36 healthy male volunteers before and after they smoked one cigarette. Results: Blood flow velocity increased to a different degree in all but one of the arteries examined after participants smoked a single cigarette: The end diastolic velocity increased significantly by 7.8% in the PCA, 8% in the ACA, and 14.4% in the MCA. The peak systolic velocity increased significantly by 7.5% in the MCA. Blood flow velocity remained unchanged in the ICA only. Blood pressure and heart rate increased as did the flow velocity ratio for the MCA/ICA. The pulsatility index decreased after smoking from 0.92 ± 0.13 to 0.87 ± 0.14 in the MCA, 0.93 ± 0.15 to 0.87 ± 0.13 in the ACA, and 0.95 ± 0.17 to 0.89 ± 0.16 in the PCA. Conclusions: The results suggest that the direct effect of smoking on cerebral circulation includes peripheral vasodilatation with possible constriction of the main trunk of the basal cerebral arteries.

Determinants of cerebral blood flow velocity change during squat-stand maneuvers

2021 ◽  
Vol 320 (4) ◽  
pp. R452-R466
Author(s):  
Ronney B. Panerai ◽  
Angus Batterham ◽  
Thompson G. Robinson ◽  
Victoria J. Haunton
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Cerebral Blood Flow Velocity ◽  
Velocity Change ◽  
Arterial Blood ◽  
Autoregulation Index ◽  
End Tidal ◽  
The Right

The large changes in mean arterial blood pressure (MABP) and cerebral blood flow velocity (CBFV) induced by squat-stand maneuvers (SSM) make this approach particularly suited for studying dynamic cerebral autoregulation (CA). However, the role of other systemic determinants of CBFV has not been described and could provide alternative physiological interpretations of SSM results. In 32 healthy subjects (16 female), continuous recordings of MABP (Finometer), bilateral CBFV (transcranial Doppler, MCA), end-tidal CO2 (EtCO2; capnography), and heart rate (HR; electrocardiogram) were performed for 5 min standing at rest, and during 15 SSM at the frequency of 0.05 Hz. A time-domain, multivariate dynamic model estimated the CBFV variance explained by different inputs, corresponding to significant contributions from MABP ( P < 0.00001), EtCO2 ( P < 0.0001), and HR ( P = 0.041). The autoregulation index (ARI; range 0–9) was estimated from the CBFV response to a step change in MABP. At rest, ARI values (typically 5.7) were independent of the number of model inputs, but during SSM, ARI was reduced compared with baseline ( P < 0.0001), and the three input model yielded lower values for the right and left MCA (3.4 ± 1.2, 3.1 ± 1.3) when compared with the single-input MABP–CBFV model (4.1 ± 1.1, 3.9 ± 1.0; P < 0.0001). The high coherence of the MABP–CBFV transfer function at 0.05 Hz (typically 0.98) was considerably reduced (around 0.71–0.73; P < 0.0001) when the contribution of CBFV covariates was taken into account. Not taking into consideration other determinants of CBFV, in addition to MABP, could be misleading and introduce biases in physiological and clinical studies.

Coupling between Visual Evoked Cerebral Blood Flow Velocity Responses and Visual Evoked Potentials in Migraneurs

Cephalalgia ◽  
2005 ◽  
Vol 25 (8) ◽  
pp. 567-574 ◽  
Author(s):  
M Zaletel ◽  
M Strucl ◽  
FF Bajrovi ◽  
T Pogacnik
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Evoked Potentials ◽  
Flow Velocity ◽  
Visual Evoked Potentials ◽  
Blood Flow Velocity ◽  
Cerebral Blood Flow Velocity ◽  
Neurovascular Coupling ◽  
Healthy Controls ◽  
Visual Evoked

Neurovascular coupling may be altered in migraneurs. Therefore, visual evoked potentials (VEP) and visually evoked cerebral blood flow velocity responses (VEFR) were simultaneously recorded in 30 healthy controls and 30 migraneurs interictally using a checkerboard stimulus with visual contrasts of 1%, 10% and 100%. The VEFR were measured in the posterior cerebral artery using transcranial Doppler and VEP were recorded from occipital leads. We found an increase in VEFR and VEP in both the healthy and migraneur groups ( P < 0.01). VEFR were significantly higher in migraneurs ( P < 0.01), while VEP did not significantly differ between the groups ( P > 0.05). Regression showed a significant association between VEP and VEFR in both healthy controls ( r = 0.66, P < 0.01) and migraneurs ( r = 0.63, P < 0.01). The regression coefficient of migraneurs (b = 0.88, SE = 0.08) was significantly higher than that of healthy controls (b = 0.55, SE = 0.07) ( P = 0.04). We conclude that neurovascular coupling is increased in migraneurs interictally.

Time-dependent improvement in coronary flow reserve in collateral donor artery following successful recanalization of the Coronary Chronic Total Occlusion

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
M Dobric ◽  
B Beleslin ◽  
M Tesic ◽  
A Djordjevic Dikic ◽  
S Stojkovic ◽  
...  
Keyword(s):  
Blood Flow ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Coronary Flow ◽  
Chronic Total Occlusion ◽  
Time Dependent ◽  
Total Occlusion ◽  
Flow Reserve ◽  
Donor Artery

Abstract Background Coronary chronic total occlusion (CTO) is characterized by the presence of collateral blood vessels which can provide additional blood supply to CTO-artery dependent myocardium. Successful CTO recanalization is followed by significant decrease in collateral donor artery blood flow and collateral derecruitment. Purpose Study aim was to assess time-dependent changes in coronary flow reserve (CFR) in collateral donor artery after CTO recanalization and identify factors that influence these changes. Methods Our study enrolled 31 patients with CTO scheduled for percutaneous coronary intervention (PCI). Non-invasive CFR was measured before PCI in collateral donor artery, and 24h and 6 months post-PCI in CTO and collateral donor artery. Gated SPECT MIBI was performed before PCI, while quality of life was assessed by Seattle angina questionnaire (SAQ) pre-PCI, and 6 months after PCI. Results Collateral donor artery showed significant increase in CFR 24h after CTO recanalization compared to pre-PCI values (2.30±0.49 vs. 2.71±0.45, p=0.005), which remained unchanged after 6 months (2.68±0.24). Maximum baseline blood flow velocity of the collateral donor artery showed significant decrease measured 24h post-PCI compared to pre-PCI values (0.28±0.06 vs. 0.24±0.04m/s), and remained similar after 6-months. There was no significant difference in maximum hyperemic blood flow velocity pre-PCI, 24h and 6 months post-PCI. CFR change of the collateral donor artery 24h post-PCI compared to pre-PCI values showed inverse correlation with left ventricle ejection fraction (LVEF) measured on SPECT. CFR changes showed no correlation with the changes in quality of life assessed by SAQ post-PCI compared to pre-PCI. Conclusions Significant increase in CFR of the collateral donor artery was observed within 24h after successful recanalization of CTO artery, which maintained constant after the 6 months follow-up. This increase was largely driven by the significant reduction in the maximum baseline blood flow velocity within 24h after CTO recanalization compared to pre-PCI values. Our results suggest that possible benefit of CTO recanalization could be the improvement in physiology of the collateral donor artery. Funding Acknowledgement Type of funding source: None

scholarly journals Blood flow velocity in the right coronary artery: Assessment before and after angioplasty

1994 ◽  
Vol 24 (4) ◽  
pp. 1012-1017 ◽  
Author(s):  
Louis I. Heller ◽  
Kevin H. Silver ◽  
Bernard J. Villegas ◽  
Sharon J. Balcom ◽  
Bonnie H. Weiner
Keyword(s):  
Blood Flow ◽  
Coronary Artery ◽  
Flow Velocity ◽  
Right Coronary Artery ◽  
Blood Flow Velocity ◽  
Before And After ◽  
The Right
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