scholarly journals A New Report of Combined Central and Peripheral Demyelination: A Case Report

2021 ◽  
Vol 12 ◽  
Author(s):  
Foziah Alshamrani ◽  
Rawan Alyami ◽  
Ibrahim Alghanimi ◽  
Reef Alajaji ◽  
Modhi Alkhaldi ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Final Diagnosis ◽  
Double Vision ◽  
Rare Disorders ◽  
Fisher Syndrome ◽  
Management Guidelines ◽  
To Come ◽  
High Level

Combined central and peripheral demyelination (CCPD) is not encountered frequently in the clinical practice, and it requires a high level of suspicion for diagnosis. We describe a case of a young man who was diagnosed with radiologically isolated syndrome (RIS) after presenting initially with symptoms suggestive of central nervous system (CNS) insult in the form of double vision, slurred speech, left-sided numbness, and unsteadiness. However, on the next day of admission, his neurological examination was remarkable for ataxia, areflexia, and ophthalmoplegia, the typical triad of Miller Fisher syndrome (MFS). After confirming both diagnoses, the final diagnosis of CCPD was made. The challenges one may face to diagnose and treat CCPD urge sharing of similar cases to open the door for further extensive and thorough investigations and to encourage further studies and analysis of available data to come up with consolidated management guidelines for rare disorders.

scholarly journals Olfactory bulb - gateway for COVID-19?

2021 ◽  
pp. 103-103
Author(s):  
Aleksandar Jovanovic ◽  
Jelena Nikovic ◽  
Nikola Boban ◽  
Radoslav Pejin ◽  
Filip Samardzic
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Mr Imaging ◽  
Olfactory Bulb ◽  
Female Patient ◽  
Brain Mri ◽  
Neurological Complications ◽  
To Come

Introduction: Anosmia and ageusia are one of the most common and characteristic symptoms of SARS-Cov-2 infection, with frequency of almost 50% in patients in Western countries. There are more and more hypotheses of potential central nervous system (CNS) affection by the virus. It is supposed that virus enters via nasal mucosa, and then via cribriform plate enters olfactory bulb, with further dissemination to the CNS. Case report: A 34-year old female patient experienced loss of smell and taste in July 2020, about two months before testing Covid-19 positive. Covid-19 presented with minor pneumonia, and worsening of anosmia and ageusia. After treatment, the patient recovered well, but anosmia and ageusia appeared again, varying in intensity, and since January 2021 became persistent. The case was evaluated by otorinolaryngologist, pulmologist, and finally neurologist. In the meantime, patient was tested Covid-19 negative and received two doses of Sputnik V vaccine. Brain MRI was performed and it clearly shows severe bilateral olfactory bulb atrophy. Thre patient has anosmia and ageusia up to this day, and future MRI follow-up is planned. Conclusion: Loss of smell and taste may be a predictor of further central nervous system dissemination of the virus, and possible neurological complications (which is still a subject of consideration). Olfactory bulb could be a gateway to Covid-19 intrusion into CNS, and its atrophy could be an indicator of that. Further investigation on this topic is required, including wide application of MR imaging in order to come to definite conclusions.

Involvement of the central nervous system in Miller Fisher syndrome: a case report

2002 ◽  
Vol 104 (4) ◽  
pp. 377-379 ◽  
Author(s):  
F.Irsel Tezer ◽  
Gunfer Gurer ◽  
Hulya Karatas ◽  
Gulay Nurlu ◽  
Okay Sarıbas
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Miller Fisher Syndrome ◽  
Fisher Syndrome ◽  
The Central Nervous System

Acute psychotic symptoms caused by overlapping central nervous system pathologies: a case report

2020 ◽  
pp. 376-379
Author(s):  
Gorkem Ugurlu ◽  
Mustafa Ugurlu ◽  
Meltem Kilic ◽  
Zuhal Apaydin ◽  
Ali Caykoylu
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Psychotic Symptoms

Primary central nervous system lymphoma: a case report

2011 ◽  
Vol 31 (7) ◽  
pp. 812-812
Author(s):  
Ai-sheng DONG ◽  
Chang-jing ZUO ◽  
Shao-yan WANG ◽  
Ming-jun GAO ◽  
Xiao-hong LI ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Central Nervous System Lymphoma

scholarly journals GCT-10. CAN HIGH LEVEL SERUM hCG-β BE CONSIDERED EQUIVALENT TO A DIAGNOSIS OF CHORIOCARCINOMA IN PRIMARY CENTRAL NERVOUS SYSTEM GERM-CELL TUMOR?

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii329-iii330
Author(s):  
Hiroaki Motegi ◽  
Shigeru Yamaguchi ◽  
Yukitomo Ishi ◽  
Michinari Okamoto ◽  
Akihiro Iguchi ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Good Prognosis ◽  
Cell Tumor ◽  
University Hospital ◽  
Kaplan Meier ◽  
Beta Human Chorionic Gonadotropin ◽  
High Level

Abstract BACKGROUND Primary central nervous system(CNS) choriocarcinoma(CC) is very rare and has the poorest prognosis among germ cell tumor (GCT). CC usually has extremely high level (HL) of serum beta-human chorionic gonadotropin (bhCG) over than 1,000 mIU/ml. Some studies assign HL bhCG cases to poor prognosis group even without biopsy. The purpose of this study was to find out if there was a good prognosis subset in the HL bh group. MATERIALS AND METHODS We analyzed 103 cases diagnosed with GCT from 1998 to 2019 in Hokkaido University Hospital and reviewed the literature of CNS CC and bhCG. Survival was assessed using Kaplan-Meier method and log-rank statistics between the group with CC component and that with no CC component but HL bhCG. RESULTS One out of 103 our cases was diagnosed as a mixed GCT with CC component and did not respond to treatment and died 9 months later. Two cases were treated as CC because of HL bhCG (1,226 and 2,739 mIU/ml) despite that the biopsy showed only germinomas and survived(105 and 37 months), that is, no CC component. Combining our cases with 69 cases in the literature, all 7 cases with no CC component but HL bhCG survived but the median survival of the other 65 cases with CC component was 38.2 months (P=0.02). CONCLUSION This study has a limitation of selection bias, however, it suggests that patients with no CC component but HL bhCG may have a better prognosis.

scholarly journals Acute central nervous system vasculitis as a manifestation of neurosarcoidosis: A case report and literature review

2021 ◽  
Vol 16 (2) ◽  
pp. 410-414
Author(s):  
Toyonobu Maekawa ◽  
Yukihiro Goto ◽  
Takuma Aoki ◽  
Akihiko Hino ◽  
Hideki Oka ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Literature Review ◽  
Central Nervous System Vasculitis
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