scholarly journals Event-Related Potentials to Changes in Sound Intensity Demonstrate Alterations in Brain Function Related to Depression and Aging

Author(s):  
Elisa M. Ruohonen ◽  
Saara Kattainen ◽  
Xueqiao Li ◽  
Anna-Elisa Taskila ◽  
Chaoxiong Ye ◽  
...  
2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
J. Maltez ◽  
D. Dias ◽  
H. Silva

After decades of neuroscientific research and taxonomic endeavour in psychiatry the quest for biologic markers specific enough to accommodate nosologic categories has not succeeded. Yet, neurophysiology and neuroimaging have developed pwoerful tools to investigate brain function. An immense amount of data has been accumulated regarding normal and pathologic information processing, cognition, emotion and other domains. Some have been correlated with genes underpinning diseases and are candidate endophenotypes. These stand at an intermediate level between genes and phenotype. They encompass several kinds of dysfunctions or abnormalities in brain structure. Rather than matching to singular diagnostic categories, as we devise them today, the same endophenotype is usually shared by distinct pathologic entities. Assuming tha they reflect specif dysfunctions this raises critical questions regarding the DSM way of classifying mental disorders and to the understanding of the neurobiologic phenomena underlying them. It is the purpose of this presentation to discuss these questions and review some of the data, including our own, concerning event-related potentials endophenotypes of psychosis with special focus on the schizophrenia-bipolar dichotomy and present.


Author(s):  
Vesa Putkinen ◽  
Mari Tervaniemi

Studies conducted during the last three decades have identified numerous differences between musicians and non-musicians in neural correlates of sensory, motor, and higher-order cognitive functions. Research employing event-related potentials/fields has been particularly important in this framework. This chapter reviews the evidence that has emerged from these studies with emphasis on longitudinal studies comparing functional brain development in children taking music lessons and those engaged in non-musical activities. The literature provides empirical and theoretical grounds for concluding that musical training enhances sound encoding skills that are relevant for both music and speech processing. The question whether the benefits of musical training transfer to more distantly related cognitive functions remains controversial, however. Finally, it appears likely that training-induced plasticity alone does not account for the differences in brain function between musicians and non-musicians and, conversely, that predisposing factors also play a role.


2001 ◽  
Vol 24 (5) ◽  
pp. 823-824 ◽  
Author(s):  
Márk Molnár

We discuss whether low-dimensional chaos and even nonlinear processes can be traced in the electrical activity of the brain. Experimental data show that the dimensional complexity of the EEG decreases during event-related potentials associated with cognitive effort. This probably represents increased nonlinear cooperation between different neural systems during sensory information processing.


2009 ◽  
Vol 59 (2) ◽  
pp. 80-86 ◽  
Author(s):  
Mutsumi Iijima ◽  
Mikio Osawa ◽  
Nobuyuki Nishitani ◽  
Makoto Iwata

2001 ◽  
Vol 40 (03) ◽  
pp. 184-189
Author(s):  
H. G. McAllister ◽  
R. Howard ◽  
L. Hong Neo ◽  
P. J. McCullagh

Abstract:Human event-related potentials reflect cognitive processing, and are normally elicited by external events, such as acoustic sounds or visual stimuli. As such they provide an opportunity to study normal and abnormal brain function noninvasively, at sub-second resolution. Advances in multimedia technology permit specialists in informatics and neuropsychology to co-operate in the design and implementation of paradigms, which influence ERP components. The paper illustrates the progression from standard paradigms such as the auditory oddball, which can be used to study memory update through to contingent negative variation and three condition, visual paradigms which can be used to study cognitive and emotional responses. Data from a study investigating the comparative processing of target pictures and words illustrate how external stimuli influence the later cognitive potentials.


BMJ Open ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. e024426 ◽  
Author(s):  
Shilpa Anand ◽  
Susan Thomas ◽  
Mahesh Jayachandra ◽  
Tinku Thomas ◽  
Tor Arne Strand ◽  
...  

IntroductionVitamin B12 deficiency is highly prevalent in pregnant Indian women. Neuropsychological tests have shown an association between low maternal vitamin B12 status and poorer cognitive performances in the offspring, although findings from these studies have been inconsistent. Vitamin B12 has an important role in the formation of myelin which is important for the transmission speed of neural impulses and myelination in the central nervous system has been linked to cognition. Assessing neurophysiological measures using event-related potentials (ERPs) in children may provide additional information on the effect of maternal vitamin B12 supplementation on offspring brain function. The study examines the effects of oral vitamin B12 daily supplements (50 µg) to pregnant Indian women on child neurophysiological function at 72 months.Methods and analysisWe previously conducted a double-blind, placebo-controlled study to examine the effects of maternal vitamin B12 supplementation on cognitive outcomes in their offspring using the Bayley scales of infant development, third edition. In this extended follow-up of the same cohort of mother-child dyad, we propose to use ERP to study the long-term impact of maternal B12 supplementation on brain function in children at 72 months of age. We intend to use P300 and mismatch negativity (MMN) as measures of neurophysiological outcomes. The primary outcome of this study will be child neurophysiological measures (as measured by amplitude and latency of P300 and MMN) assessed at 72 months of age in children whose mothers received vitamin B12 compared with neurophysiological status of children whose mothers received placebo.Ethics and disseminationThe study was approved by the Institutional Ethical Board of St. John’s Medical College and the Harvard School of Public Health Human Subjects Committee. Results obtained will be presented at national and international research meetings and published in peer-reviewed scientific journals.Trial registration numberNCT00641862.


2017 ◽  
Vol 41 (S1) ◽  
pp. S192-S192
Author(s):  
G. Di Lorenzo ◽  
A. Mucci ◽  
A. Vignapiano ◽  
G. Giordano ◽  
F. Ferrentino ◽  
...  

IntroductionThe effects of chronic antipsychotic administration on the human brain are debated. In particular, first-generation (FGAs) and second-generation antipsychotics (SGAs) seem to have different impacts on brain function and structure in subjects with schizophrenia. Few studies have investigated the effect of chronic administration of FGAs and SGAs on indices of brain function, such as event-related potentials (ERP) or neuropsychological performance.ObjectivesWithin the Italian Network for Research on Psychoses study, subjects stabilized on FGAs or SGAs were compared on P300, an ERP component, thought to reflect attention, working memory and context integration and on neurocognitive indices.MethodsERPs were recorded in 110 chronic, stabilized patients with Schizophrenia (28 used FGAs) during a standard auditory oddball task. P300 latency and amplitude were assessed at Pz channel. MATRICS Consensus Cognitive Battery (MCCB) was used for cognitive assessment.ResultsCompared with the SGAs group, patients on FGAs showed significant increased P300 latency (P = 0.003; Cohen's d = 0.67) and significant decreased P300 amplitudes (P = 0.023; Cohen's d = 0.38). The two groups did not differ on psychopathology and MCCB scores. Multiple linear regressions revealed that “FGAs vs. SGAs” (β = 0.298, P = 0.002) and MCCB neurocognitive composite T-score (β = –0.273, P = 0.004) were independent predictors of P300 latency, whereas only age (β = –0.220, P = 0.027) was an independent predictor of P300 amplitude.ConclusionsFGAs seem to affect the functional brain activity more than SGAs, particularly slowing cortical processing. Our results suggest that discrepant findings concerning P300 latency in schizophrenia might be related to the type of antipsychotic treatment used. Longitudinal studies are needed to further address this issue.Disclosure of interestThe authors have not supplied their declaration of competing interest.


2011 ◽  
Vol 148-149 ◽  
pp. 30-33
Author(s):  
Gai Ling Fan ◽  
Zhi Hua Huang

EEG (electroencephalography), as a noninvasive and inexpensive method, is widely used to measure brain function and make inferences about regional brain activity. The stationarity of EEG has been investigated by many researchers, while the stationarity of EEG segment with ERPs (Event-related Potentials) has hardly been concerned about. It is necessary to analyze the stationarity of this kind of EEG. In this paper, we concentrate on the stationarity of the EEG with ERPs by testing the stationarity of 500ms EEG segments with ERPs recorded from six subjects in two types of experiments. The results suggest that selected EEG segment whose length is larger than 190ms remains to be stationarity and all epochs duration less than 40ms is considered to be stationary, whichever channel the data is from and whatever type of cognitive task is performed in the experiment. This is an obvious difference between the stationarity of EEG with ERPs and that of EEG, which is reported to be stationary as long as its length is less than 12s.


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