Clinical and behavioral correlates in adult methamphetamine users with childhood exposure to household drug and alcohol use

Aims: To describe and compare methamphetamine (MA) users with and without a family history of alcohol or drug () use in the household. Design: A total of 1144 Thai-speaking MA users in Thailand were recruited for a cohort study. Cross-sectional baseline data were analyzed according to their exposure to FAOD use (FAOD+/FAOD-). The Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) was utilized to collect baseline socio-demographic information and variables known to be associated with the impact of FAOD use. Findings: FAOD+ participants had lower average years of education (p<0.01), fewer average months of employment in the past year (p<0.01) and reported higher rates of self-harm experience (p<0.001), gambling (p=0.018) and antisocial personality disorder (p=0.015). FAOD+ participants had more severe clinical, adverse consequences. FAOD+ significantly predicted episodes of lifetime MA use (R2 =0.004, p=0.032), the largest number of drinks ever had in a 24-hour period (R2 =0.01, p=0.001), paranoid experiences ([OR]=1.090, p=0.004), alcohol dependence ([OR]=1.112, p=0.001) and antisocial personality disorder ([OR]=1.139, p=0.015). FAOD+ participants who were exposed to alcohol only were more likely to report a significantly higher number of drinks ever had in a 24-hour periods (p<0.005). Similarly, FAOD+ participants who were exposed to MA use only were significantly more likely to report more frequent use of MA (p<0.005). Conclusions: FAOD+ participants were characterized by a generally more severe clinical presentation than FAOD- participants. Moreover, we show the specificity of drug type mattered, with family exposure of alcohol and MA associated with greater subsequent use of the respective drugs.

Examination of Fear of Missing Out (FOMO) States of Students Who Study at the School of Physical Education and Sports in Terms of Some Variables

The aim of this study is to examine the frequency rate of FOMO (Fear of Missing Out) in both male and female students under some variables. Social media platforms which became an inseparable part of daily life have caused individuals to spend more time in the virtual world. From Sports Sciences, a total of 465 students (274 males and 191 females) who study in different departments and who are in different grades have participated in the present study which is pretty limited availably in Turkish in the literature. In the research, "Fear of Missing Out in Social Settings Scale" the Turkish version that is adapted by (Gökler et al., 2016) of the scale “Motivational, emotional, and behavioral correlates of fear of missing out" which is developed by (Przybylski, 2013) was used as a data collection tool. In the present study, statistical analysis of data has been performed through SPSS 26 program, t-tests, and One Way ANOVA tests. According to T-test results of FOMO averages based on sex, no significant difference has been found. It has been established that students who are not engaged in any sports activity (X=4.05) have a higher rate of FOMO on social media as compared to those who play sports (X=2.95), it has been established that students who check their phones right after they wake up (X=3.70) and students who spend time with their phones before sleeping (X=3.75) have higher FOMO averages as compared to those who don't check (X=3.40) or spend time with their phones(X=3,42). A significant difference has been detected (p>0.05). According to One Way ANOVA Post-toc tests which were based on daily social media usage durations and departments of the students. No significant difference has been established FOMO levels of students based on the grade they are in and the number of social media they own.

Examination of Fear of Missing Out (FOMO) States of Students Who Study at the School of Physical Education and Sports in Terms of Some Variables

The aim of this study is to examine the frequency rate of FOMO (Fear of Missing Out) in both male and female students under some variables. Social media platforms which became an inseparable part of daily life have caused individuals to spend more time in the virtual world. From Sports Sciences, a total of 465 students (274 males and 191 females) who study in different departments and who are in different grades have participated in the present study which is pretty limited availably in Turkish in the literature. In the research, "Fear of Missing Out in Social Settings Scale" the Turkish version that is adapted by (Gökler et al., 2016) of the scale “Motivational, emotional, and behavioral correlates of fear of missing out" which is developed by (Przybylski, 2013) was used as a data collection tool. In the present study, statistical analysis of data has been performed through SPSS 26 program, t-tests, and One Way ANOVA tests. According to T-test results of FOMO averages based on sex, no significant difference has been found. It has been established that students who are not engaged in any sports activity (X=4.05) have a higher rate of FOMO on social media as compared to those who play sports (X=2.95), it has been established that students who check their phones right after they wake up (X=3.70) and students who spend time with their phones before sleeping (X=3.75) have higher FOMO averages as compared to those who don't check (X=3.40) or spend time with their phones(X=3,42). A significant difference has been detected (p&gt;0.05). According to One Way ANOVA Post-toc tests which were based on daily social media usage durations and departments of the students. No significant difference has been established FOMO levels of students based on the grade they are in and the number of social media they own.

Behavioral correlates of subjective cognitive decline in the Canadian Longitudinal Study on Aging (CLSA)

Subjective cognitive decline (SCD) is a self-reported decline in cognition among otherwise cognitively healthy older adults. It is believed that SCD may be a precursor to Alzheimer’s Disease (AD). Analyzing data from the Canadian Longitudinal Study on Aging (CLSA), a large national sample of participants aged 45-85 at baseline, we sought to identify prospective relationships between health-related behaviors and SCD. Exposures were measured at baseline and SCD was measured three years later, with the question: “Do you feel like your memory is becoming worse?”. A multivariable logistic regression model was used to estimate odds of SCD (analytic sample: n=35,680). Alcohol consumption was associated with increased odds of SCD, with regular drinkers (OR=1.13, 95% CI: 1.04, 1.22) and frequent drinkers (OR=1.17, 95% CI: 1.08, 1.27) more likely to report SCD than never drinkers. Compared to participants who never smoked, former smokers had increased odds of SCD (OR=1.13, 95% CI: 1.08, 1.18), whereas current smokers had reduced odds of SCD (OR=0.90, 95% CI: 0.83, 0.98). Participants who consumed five or more servings of fruits/ vegetables had reduced odds of SCD (OR=0.95, 95% CI: 0.91, 0.99), when compared to those who consumed &lt;5 servings. Lastly, we did not observe any associations between walking and SCD. This study identifies relationships between various health-related behaviors and SCD in a large population-based sample of older Canadians. Identification of modifiable risk factors may help with early prevention and intervention of SCD.

Multistable Perception

Multistable perception is produced by stimuli that are consistent with two or more different comparably likely perceptual interpretations. After the initial perception is resolved in favor of one of the interpretations, continued viewing leads to fluctuating subjective experience, as perception spontaneously switches between alternative states. Multistable perception occurs for different modalities, including visual, auditory, tactile, olfactory perception and proprioception, and various conflicting sensory representations, such as eye dominance, depth, motion, or meaning. Despite large differences, multistable stimuli produce quantitatively similar perceptual experience with stereotypical distribution of durations of dominance phases, similar dependence on the absolute and relative strength of competing perceptual interpretations, prior perceptual history, presentation method, attention, and volitional control, and so on. Taken together, this shows that multistable perception reflects the action of general canonical perceptual mechanisms whose purpose is to resolve the conflicting evidence and ensure a single dominant perception that can be used for action. Thus, it informs us about mechanisms of perceptual decision making, including the importance of feedback mechanisms in resolving perceptual ambiguity and the role of parietal and frontal regions in facilitating changes in perception. Multistable perception provides useful constraints for models, inspiring a plethora of models of perception that combine neurally plausible mechanisms, such as neural adaptation and inhibition, or are based on the idea of predictive coding. The sensitive nature of multistable perception makes a valuable experimental tool that can reveal even minor differences due to low- or high-level influences, including genetic or clinical cases. As such, it is an important tool in studying neural and behavioral correlates of consciousness as it dissociates perception from the stimulus.

EEG and behavioral correlates of attentional processing while walking and navigating naturalistic environments

The capacity to regulate one’s attention in accordance with fluctuating task demands and environmental contexts is an essential feature of adaptive behavior. Although the electrophysiological correlates of attentional processing have been extensively studied in the laboratory, relatively little is known about the way they unfold under more variable, ecologically-valid conditions. Accordingly, this study employed a ‘real-world’ EEG design to investigate how attentional processing varies under increasing cognitive, motor, and environmental demands. Forty-four participants were exposed to an auditory oddball task while (1) sitting in a quiet room inside the lab, (2) walking around a sports field, and (3) wayfinding across a university campus. In each condition, participants were instructed to either count or ignore oddball stimuli. While behavioral performance was similar across the lab and field conditions, oddball count accuracy was significantly reduced in the campus condition. Moreover, event-related potential components (mismatch negativity and P3) elicited in both ‘real-world’ settings differed significantly from those obtained under laboratory conditions. These findings demonstrate the impact of environmental factors on attentional processing during simultaneously-performed motor and cognitive tasks, highlighting the value of incorporating dynamic and unpredictable contexts within naturalistic designs.

Behavioral and postural analyses establish sleep-like states for mosquitoes that can impact interactions with hosts

Sleep is an evolutionarily conserved process that has been described in different animal systems. For insects, sleep characterization has been primarily achieved using behavioral and electrophysiological correlates in a few systems. Sleep in mosquitoes, which are important vectors of disease-causing pathogens, has not been directly examined. This is surprising as circadian rhythms, which have been well studied in mosquitoes, influence sleep in other systems. In this study, we characterized sleep in mosquitoes using body posture analysis and behavioral correlates, and quantified the effect of sleep deprivation on sleep rebound and host landing. Body and appendage position metrics revealed a clear distinction between the posture of mosquitoes in their putative sleep and awake states for multiple species, which correlates with a reduction in responsiveness to host cues. Sleep assessment informed by these posture analyses indicated significantly more sleep during periods of low activity. Nighttime and daytime sleep deprivation resulting from the delivery of vibration stimuli induced sleep rebound in the subsequent phase in day and night active mosquitoes, respectively. Lastly, sleep deprivation suppressed host landing in both laboratory and field settings when mosquitoes would normally be active. These results suggest that quantifiable sleep states occur in mosquitoes, and highlight the potential epidemiological importance of mosquito sleep.

Multiple metals in children’s deciduous teeth: results from a community-initiated pilot study

Background Characterizing retrospective exposure to toxicants during multiple early-life developmental periods is challenging, yet critical for understanding developmental effects. Objective To characterize early-life metal exposure using deciduous teeth in a community concerned about past exposures. Methods Naturally shed teeth were collected from 30 children ages 5–13 years who resided in Holliston, Massachusetts since conception. We estimated weekly prenatal and postnatal (up to 1 year of age) exposure to 12 metals by measuring dentine concentrations using laser ablation-inductively coupled plasma-mass spectrometry. Multivariable linear mixed models were used to explore sociodemographic, dietary, and behavioral correlates of dentine metal concentrations. Results Temporal trends in dentine levels differed by metal. Source of milk during the first year of life was associated with dentine barium (Ba) levels, where being fed predominantly breastmilk was associated with 39% (95% CI: –57%, –13%) lower dentine Ba compared to predominantly formula use. Females had higher prenatal and postnatal dentine Mn and Pb, compared to males (e.g., % difference, postnatal Mn: 122% (17%, 321%); postnatal Pb: 60% (95% CI: –8%, 178%)). Significance Deciduous teeth provide retrospective information on dose and timing of early-life metals exposure at high resolution. We demonstrate their utility in a community-based study with known past contamination of drinking water. Impact statement We conducted a community-initiated pilot study in a community concerned with historical exposure to multiple metals. Using deciduous teeth, a novel noninvasive biomarker, we characterized early-life exposure to 12 metals in approximately weekly increments during sensitive developmental periods, thus demonstrating the utility of this biomarker in communities concerned with past exposures.

GABAA and NMDA receptor density alterations and their behavioral correlates in the gestational methylazoxymethanol acetate model for schizophrenia

Hippocampal hyperactivity driven by GABAergic interneuron deficits and NMDA receptor hypofunction is associated with the hyperdopaminergic state often observed in schizophrenia. Furthermore, previous research in the methylazoxymethanol acetate (MAM) rat model has demonstrated that repeated peripubertal diazepam administration can prevent the emergence of adult hippocampal hyperactivity, dopamine-system hyperactivity, and associated psychosis-relevant behaviors. Here, we sought to characterize hippocampal GABAA and NMDA receptors in MAM-treated rats and to elucidate the receptor mechanisms underlying the promising effects of peripubertal diazepam exposure. Quantitative receptor autoradiography was used to measure receptor density in the dorsal hippocampus CA1, ventral hippocampus CA1, and ventral subiculum. Specifically, [3H]-Ro15-4513 was used to quantify the density of α5GABAA receptors (α5GABAAR), [3H]-flumazenil to quantify α1-3;5GABAAR, and [3H]-MK801 to quantify NMDA receptors. MAM rats exhibited anxiety and schizophrenia-relevant behaviors as measured by elevated plus maze and amphetamine-induced hyperlocomotion (AIH), although diazepam only partially rescued these behaviors. α5GABAAR density was reduced in MAM-treated rats in all hippocampal sub-regions, and negatively correlated with AIH. Ventral hippocampus CA1 α5GABAAR density was positively correlated with anxiety-like behavior. Dorsal hippocampus CA1 NMDA receptor density was increased in MAM-treated rats, and positively correlated with AIH. [3H]-flumazenil revealed no significant effects. Finally, we found no significant effect of diazepam treatment on receptor densities, potentially related to the only partial rescue of schizophrenia-relevant phenotypes. Overall, our findings provide first evidence of α5GABAAR and NMDA receptor abnormalities in the MAM model, suggesting that more selective pharmacological agents may become a novel therapeutic mechanism in schizophrenia.