scholarly journals Parietal Cortex Connectivity as a Marker of Shift in Spatial Attention Following Continuous Theta Burst Stimulation

2021 ◽  
Vol 15 ◽  
Author(s):  
Jessica Mariner ◽  
Tobias Loetscher ◽  
Brenton Hordacre
Keyword(s):  
Functional Connectivity ◽  
Spatial Attention ◽  
Brain Stimulation ◽  
Resting State ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Resting State Functional Connectivity ◽  
The Right ◽  
Theta Burst ◽  
Continuous Theta Burst Stimulation

Non-invasive brain stimulation is a useful tool to probe brain function and provide therapeutic treatments in disease. When applied to the right posterior parietal cortex (PPC) of healthy participants, it is possible to temporarily shift spatial attention and mimic symptoms of spatial neglect. However, the field of brain stimulation is plagued by issues of high response variability. The aim of this study was to investigate baseline functional connectivity as a predictor of response to an inhibitory brain stimulation paradigm applied to the right PPC. In fourteen healthy adults (9 female, aged 24.8 ± 4.0 years) we applied continuous theta burst stimulation (cTBS) to suppress activity in the right PPC. Resting state functional connectivity was quantified by recording electroencephalography and assessing phase consistency. Spatial attention was assessed before and after cTBS with the Landmark Task. Finally, known determinants of response to brain stimulation were controlled for to enable robust investigation of the influence of resting state connectivity on cTBS response. We observed significant inter-individual variability in the behavioral response to cTBS with 53.8% of participants demonstrating the expected rightward shift in spatial attention. Baseline high beta connectivity between the right PPC, dorsomedial pre-motor region and left temporal-parietal region was strongly associated with cTBS response (R2 = 0.51). Regression analysis combining known cTBS determinants (age, sex, motor threshold, physical activity, stress) found connectivity between the right PPC and left temporal-parietal region was the only significant variable (p = 0.011). These results suggest baseline resting state functional connectivity is a strong predictor of a shift in spatial attention following cTBS. Findings from this study help further understand the mechanism by which cTBS modifies cortical function and could be used to improve the reliability of brain stimulation protocols.

scholarly journals The Modulatory Effects of Intermittent Theta Burst Stimulation in Combination With Mirror Hand Motor Training on Functional Connectivity: A Proof-of-Concept Study

2021 ◽  
Vol 15 ◽  
Author(s):  
Jack Jiaqi Zhang ◽  
Kenneth N. K. Fong
Keyword(s):  
Functional Connectivity ◽  
Motor Cortex ◽  
Resting State ◽  
Healthy Adults ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Group 3 ◽  
Group 2 ◽  
Theta Burst ◽  
Group 1

Mirror training (MT) is an observation-based motor learning strategy. Intermittent theta burst stimulation (iTBS) is an accelerated form of excitatory repetitive transcranial magnetic stimulation (rTMS) that has been used to enhance the cortical excitability of the motor cortices. This study aims to investigate the combined effects of iTBS with MT on the resting state functional connectivity at alpha frequency band in healthy adults. Eighteen healthy adults were randomized into one of three groups—Group 1: iTBS plus MT, Group 2: iTBS plus sham MT, and Group 3: sham iTBS plus MT. Participants in Groups 1 and 3 observed the mirror illusion of the moving (right) hand in a plain mirror for four consecutive sessions, one session/day, while participants in Group 2 received the same training with a covered mirror. Real or sham iTBS was applied daily over right motor cortex prior to the training. Resting state electroencephalography (EEG) at baseline and post-training was recorded when participants closed their eyes. The mixed-effects model demonstrated a significant interaction effect in the coherence between FC4 and C4 channels, favoring participants in Group 1 over Group 3 (Δβ = −0.84, p = 0.048). A similar effect was also found in the coherence between FC3 and FC4 channels favoring Group 1 over Group 3 (Δβ = −0.43, p = 0.049). In contrast to sham iTBS combined with MT, iTBS combined with MT may strengthen the functional connectivity between bilateral premotor cortices and ipsilaterally within the motor cortex of the stimulated hemisphere. In contrast to sham MT, real MT, when combined with iTBS, might diminish the connectivity among the contralateral parietal–frontal areas.

Modulation of cognitive cerebello-cerebral functional connectivity by lateral cerebellar continuous theta burst stimulation

NeuroImage ◽  
2017 ◽  
Vol 158 ◽  
pp. 48-57 ◽  
Author(s):  
Anuj Rastogi ◽  
Robin Cash ◽  
Katharine Dunlop ◽  
Michael Vesia ◽  
Aaron Kucyi ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Theta Burst ◽  
Continuous Theta Burst Stimulation

scholarly journals Individual resting‐state frontocingular functional connectivity predicts the intermittent theta burst stimulation response to stress in healthy female volunteers

2020 ◽  
Vol 41 (18) ◽  
pp. 5301-5312
Author(s):  
Linde Wandel ◽  
Matias M. Pulopulos ◽  
Vytautas Labanauskas ◽  
Sara Witte ◽  
Marie‐Anne Vanderhasselt ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Healthy Female ◽  
Response To Stress ◽  
Theta Burst
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