Evaluating Heterogeneity of Primary Lung Tumor Using Clinical Routine Magnetic Resonance Imaging and a Tumor Heterogeneity Index

ObjectiveTo improve the assessment of primary tumor heterogeneity in magnetic resonance imaging (MRI) of non-small cell lung cancer (NSCLC), we proposed a method using basic measurements from T1- and T2-weighted MRI.MethodsOne hundred and four NSCLC patients with different T stages were studied. Fifty-two patients were analyzed as training group and another 52 as testing group. The ratios of standard deviation (SD)/mean signal value of primary tumor from T1-weighted (T1WI), T1-enhanced (T1C), T2-weighted (T2WI), and T2 fat suppression (T2fs) images were calculated. In the training group, correlation analyses were performed between the ratios and T stages. Then an ordinal regression model was built to generate the tumor heterogeneous index (THI) for evaluating the heterogeneity of tumor. The model was validated in the testing group.ResultsThere were 11, 32, 40, and 21 patients with T1, T2, T3, and T4 disease, respectively. In the training group, the median SD/mean on T1WI, T1C, T2WI, and T2fs sequences was 0.11, 0.19, 0.16, and 0.15 respectively. The SD/mean on T1C (p=0.003), T2WI (p=0.000), and T2fs sequences (p=0.002) correlated significantly with T stages. Patients with more advanced T stage showed higher SD/mean on T2-weighted, T2fs, and T1C sequences. The median THI in the training group was 2.15. THI correlated with T stage significantly (p=0.000). In the testing group, THI was also significantly related to T stages (p=0.001). Higher THI had relevance to more advanced T stage.ConclusionsThe proposed ratio measurements and THI based on MRI can serve as functional radiomic markers that correlated with T stages for evaluating heterogeneity of lung tumors.

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Oropharyngeal primary tumor segmentation for radiotherapy planning on magnetic resonance imaging using deep learning

Physics and Imaging in Radiation Oncology ◽

10.1016/j.phro.2021.06.005 ◽

2021 ◽

Vol 19 ◽

pp. 39-44

Author(s):

Roque Rodríguez Outeiral ◽

Paula Bos ◽

Abrahim Al-Mamgani ◽

Bas Jasperse ◽

Rita Simões ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Deep Learning ◽

Magnetic Resonance ◽

Primary Tumor ◽

Radiotherapy Planning ◽

Tumor Segmentation ◽

Resonance Imaging

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Cortical pathology in multiple sclerosis detected by the T1/T2-weighted ratio from routine magnetic resonance imaging

Annals of Neurology ◽

10.1002/ana.25020 ◽

2017 ◽

Vol 82 (4) ◽

pp. 519-529 ◽

Cited By ~ 37

Author(s):

Ruthger Righart ◽

Viola Biberacher ◽

Laura E. Jonkman ◽

Roel Klaver ◽

Paul Schmidt ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Multiple Sclerosis ◽

Magnetic Resonance ◽

Resonance Imaging ◽

Routine Magnetic Resonance Imaging ◽

Cortical Pathology

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Morphometric relationships between dimensions the anterior talofibular ligament and calcaneofibular ligament in routine magnetic resonance imaging

Journal of Experimental Orthopaedics ◽

10.1186/s40634-021-00406-2 ◽

2021 ◽

Vol 8 (1) ◽

Author(s):

Pawel Szaro ◽

Khaldun Ghali Gataa ◽

Nektarios Solidakis ◽

Przemysław Pękala

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Negative Correlation ◽

Biomechanical Model ◽

Anterior Talofibular Ligament ◽

Resonance Imaging ◽

Calcaneofibular Ligament ◽

Level Of Evidence ◽

Human Foot ◽

Routine Magnetic Resonance Imaging

Abstract Purpose This study aimed to test the hypothesis that routine MRI ankle can be used to evaluate dimensions and correlations between dimensions of single and double fascicular variants of the ATFL and the CFL. Methods We reviewed ankle MRIs for 251 patients. Differences between the length, thickness, width, and length of the bony attachments were evaluated twice. P < .05 was considered as significant. Results For the ATFL, we observed a negative correlation between thickness and width, with a positive correlation between thickness and length (p < 0.001). The average values for the ATFL were thickness, 2.2 ± 0.05 mm; length, 21.5 ± 0.5 mm; and width, 7.6 ± 0.6 mm. The average values for the CFL were thickness, 2.1 ± 0.04 mm; length, 27.5 ± 0.5 mm; and width, 5.6 ± 0.3 mm. A negative correlation was found between length and width for the CFL (p < 0.001). Conclusions Routine MRI showed that most dimensions of the ATFL and CFL correlate with each other, which should be considered when planning new reconstruction techniques and developing a virtual biomechanical model of the human foot. Level of evidence III

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Prevalence of sclerosing cholangitis in adults with autoimmune hepatitis: Evaluating the role of routine magnetic resonance imaging

Hepatology ◽

10.1002/hep.22073 ◽

2007 ◽

Vol 47 (3) ◽

pp. 949-957 ◽

Cited By ~ 88

Author(s):

Rupert Abdalian ◽

Preeti Dhar ◽

Kartik Jhaveri ◽

Masoom Haider ◽

Maha Guindi ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Autoimmune Hepatitis ◽

Sclerosing Cholangitis ◽

Resonance Imaging ◽

Routine Magnetic Resonance Imaging

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The Crank Test, the O'Brien Test, and Routine Magnetic Resonance Imaging Scans in the Diagnosis of Labral Tears

The American Journal of Sports Medicine ◽

10.1177/03635465020300060901 ◽

2002 ◽

Vol 30 (6) ◽

pp. 806-809 ◽

Cited By ~ 91

Author(s):

William B. Stetson ◽

Kevin Templin

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Positive Predictive Value ◽

Negative Predictive Value ◽

Predictive Value ◽

Shoulder Arthroscopy ◽

Rotator Cuff Tears ◽

Resonance Imaging ◽

Routine Magnetic Resonance Imaging ◽

Labral Tears

Background Tears of the superior labrum of the shoulder, anterior to posterior, are difficult to diagnose clinically. Purpose We examined whether the crank or O'Brien tests were reliable tools for detecting glenoid labral tears. Study Design Nonrandomized prospective study. Methods Results of diagnostic shoulder arthroscopy were compared with those of the preoperative tests and magnetic resonance imaging for 65 patients who had symptoms of shoulder pain. Results The crank test result was positive in 29 patients (45%), and the O'Brien test was positive in 41 patients (63%). The crank test had a positive predictive value of 41%, was 56% specific, 46% sensitive, and had a negative predictive value of 61%. The O'Brien test had a positive predictive value of 34%, was 31% specific, 54% sensitive, and had a negative predictive value of 50%. Magnetic resonance imaging had a positive predictive value of 63%, was 92% specific, 42% sensitive, and had a negative predictive value of 83%. Conclusions The O'Brien and crank tests were not sensitive clinical indicators for detecting glenoid labral tears and other tears of the anterior and posterior labrum. Results were often falsely positive for patients with other shoulder conditions, including impingement or rotator cuff tears.

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