scholarly journals Association Between 18F-FDG PET/CT-Based SUV Index and Malignant Status of Persistent Ground-Glass Nodules

2021 ◽  
Vol 11 ◽  
Author(s):  
Rong Niu ◽  
Yuetao Wang ◽  
Xiaoliang Shao ◽  
Zhenxing Jiang ◽  
Jianfeng Wang ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Correlation Factor ◽  
Ground Glass ◽  
Imaging Data ◽  
Malignancy Risk ◽  
Pet Ct ◽  
Average Probability ◽  
Fdg Pet Ct ◽  
Benign Group ◽  
Ground Glass Nodules

To explore the association between 18F-FDG PET/CT-based SUV index and malignant risk of persistent ground-glass nodules (GGNs). We retrospectively analyzed a total of 166 patients with GGN who underwent PET/CT examination from January 2012 to October 2019. There were 113 women and 53 men, with an average age of 60.8 ± 9.1 years old. A total of 192 GGNs were resected and confirmed by pathology, including 22 in benign group and 170 in adenocarcinoma group. They were divided into three groups according to SUV index tertiles: Tertile 1 (0.14–0.54), Tertile 2 (0.55–1.17), and Tertile 3 (1.19–6.78), with 64 GGNs in each group. The clinical and imaging data of all patients were collected and analyzed. After adjusting for the potential confounding factors, we found that the malignancy risk of GGN significantly decreased as the SUV index increased (OR, 0.245; 95%CI, 0.119–0.504; P <0.001), the average probability of malignant GGN was 89.1% (95% CI, 53.1–98.3%), 80.5% (95% CI, 36.7–96.7%), and 34.3% (95%CI, 9.5–72.2%) for Tertile 1 to Tertile 3. And the increasing trend of SUV index was significantly correlated with the reduction of malignant risk (OR, 0.099; 95%CI, 0.025–0.394; P = 0.001), especially between Tertile 3 versus Tertile 1 (OR, 0.064; 95%CI, 0.012–0.356; P = 0.002). Curve fitting showed that the SUV index was linearly and negatively correlated with the malignant risk of GGN. SUV index is an independent correlation factor for malignancy risk of GGN, the higher the SUV index, the lower the probability of GGN malignancy.

Differentiation between malignancy and inflammation in pulmonary ground-glass nodules: The feasibility of integrated 18F-FDG PET/CT

Lung Cancer ◽  
2009 ◽  
Vol 65 (2) ◽  
pp. 180-186 ◽  
Author(s):  
Eun Ju Chun ◽  
Hyun Ju Lee ◽  
Won Jun Kang ◽  
Kwang Gi Kim ◽  
Jin Mo Goo ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Ground Glass ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Ground Glass Nodules

Shorter-time dual-phase FDG PET/CT in characterizing solid or ground-glass nodules based on surgical results

2012 ◽  
Vol 36 (5) ◽  
pp. 509-514 ◽  
Author(s):  
Chen-Feng Chiu ◽  
Yu-Yi Lin ◽  
Wu-Huei Hsu ◽  
Chih-Yi Chen ◽  
Jun-Jun Yeh ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Ground Glass ◽  
Dual Phase ◽  
Surgical Results ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Ground Glass Nodules

scholarly journals Maximum Standardized Uptake Value of 18F-deoxyglucose PET Imaging Increases the Effectiveness of CT Radiomics in Differentiating Benign and Malignant Pulmonary Ground-Glass Nodules

2021 ◽  
Vol 11 ◽  
Author(s):  
Rong Niu ◽  
Jianxiong Gao ◽  
Xiaoliang Shao ◽  
Jianfeng Wang ◽  
Zhenxing Jiang ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Fdg Pet ◽  
Standardized Uptake Value ◽  
Ground Glass ◽  
Semantic Features ◽  
Diagnostic Efficiency ◽  
Maximum Standardized Uptake Value ◽  
Pet Ct ◽  
Significant Difference ◽  
Ground Glass Nodules

To investigate whether the maximum standardized uptake value (SUVmax) of 18F-deoxyglucose (FDG) PET imaging can increase the diagnostic efficiency of CT radiomics-based prediction model in differentiating benign and malignant pulmonary ground-glass nodules (GGNs). We retrospectively collected 190 GGNs from 165 patients who underwent 18F-FDG PET/CT examination from January 2012 to March 2020. Propensity score matching (PSM) was performed to select GGNs with similar baseline characteristics. LIFEx software was used to extract 49 CT radiomic features, and the least absolute shrinkage and selection operator (LASSO) algorithm was used to select parameters and establish the Rad-score. Logistic regression analysis was performed combined with semantic features to construct a CT radiomics model, which was combined with SUVmax to establish the PET + CT radiomics model. Receiver operating characteristic (ROC) was used to compare the diagnostic efficacy of different models. After PSM at 1:4, 190 GGNs were divided into benign group (n = 23) and adenocarcinoma group (n = 92). After texture analysis, the Rad-score with three CT texture features was constructed for each nodule. Compared with the Rad-score and CT radiomics model (AUC: 0.704 (95%CI: 0.562-0.845) and 0.908 (95%CI: 0.842-0.975), respectively), PET + CT radiomics model had the best diagnostic efficiency (AUC: 0.940, 95%CI: 0.889-0.990), and there was significant difference between each two of them (P = 0.001-0.030). SUVmax can effectively improve CT radiomics model performance in the differential diagnosis of benign and malignant GGNs. PET + CT radiomics might become a noninvasive and reliable method for differentiating of GGNs.

scholarly journals Rapidly growing pulmonary ground-glass nodule caused by metastatic melanoma lacking uptake on 18F-FDG PET-CT

2018 ◽  
Vol 44 (2) ◽  
pp. 171-172 ◽  
Author(s):  
Giorgia Dalpiaz ◽  
Sofia Asioli ◽  
Stefano Fanti ◽  
Gaetano Rea ◽  
Edson Marchiori
Keyword(s):  
Metastatic Melanoma ◽  
Fdg Pet ◽  
Ground Glass ◽  
Pet Ct ◽  
Ground Glass Nodule ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Prognostic parameters in recurrent colorectal cancer: A role of control or restaging by FDG-PET/CT

2020 ◽  
Vol 77 (2) ◽  
pp. 201-208
Author(s):  
Oguz Hancerliogullari ◽  
Kursat Okuyucu ◽  
Semra Ince ◽  
Subutay Peker ◽  
Nuri Arslan
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Fdg Pet ◽  
Tumor Differentiation ◽  
Fdg Uptake ◽  
Pet Ct ◽  
Serum Carcinoembryonic Antigen ◽  
Malignant Group ◽  
Fdg Pet Ct ◽  
Benign Group

Background/Aim. Colorectal cancer ranks the third most frequent cancer in the world. Approximately 40% of the disease recurs after surgical resection. Determination of predictive parameters for recurrence may help in stratification of patients and contribute to patient management. There are still very few studies which sought factors to predict the recurrence of colorectal cancer. The aim of this study was to examine the predefined risk factors in metastatic development and evaluate clinical significance of 18Ffluorodeoxyglucose (FDG) uptake. Methods. The study was conducted with 56 patients for whom FDG-PET/CT (FDG-positron emission tomography/computed tomography) was requested for the suspicious recurrence or metastasis by routine conventional screening tests. Thirty three patients in whom recurrence/metastases were established with final histopathologic diagnosis formed the malignant group, and 23 patients with no recurrence/metastases formed the benign group. Risk factors [age, serum carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (Ca 19-9) levels, the maximum standardized uptake volume (SUVmax), tumor size (TS), CT/magnetic resonance imaging (MRI) findings, sex, primary tumor localization, lymphovascular invasion, perineural invasion (PNI), initial neoadjuvant therapy, lymph node initial metastasis (ILNM) excision, stage, tumor differentiation] were compared between these groups. Results. CEA, Ca 19-9, SUVmax, TS, PNI, ILNM, FDG uptake pattern, pattern of lesions on CT and tumor differentiation were found statistically significant by univariate analysis. After multivariate analysis, SUVmax and ILNM remained as the main risk parameters impacting recurrence/metastases. Mean SUVmax was 7.25 in the benign group, while it was 11.7 in the malignant group (p = 0.019). ILNM was present in 66.5% of patients in the malignant group, and in 30.5% of patients in the benign group (p = 0.015). For an estimated cut-off value of 6.3 and 12.5, respectively on ROC curve, the calculated specificities were 61% and 87%, respectively. Conclusion. ILNM and SUVmax are the main risk factors for recurrence of colorectal cancer and the patients with these factors must be followed up carefully. FDG-PET/CT is very sensitive for the detection of recurrence/metastases of colorectal cancer and SUVmax appears to improve its specificity.

scholarly journals Evaluation of Malignancy Risk in 18F-FDG PET/CT Thyroid Incidentalomas

Diagnostics ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 92 ◽  
Author(s):  
Larg ◽  
Apostu ◽  
Peștean ◽  
Gabora ◽  
Bădulescu ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Standard Uptake Value ◽  
Needle Aspiration ◽  
Malignancy Risk ◽  
Positron Emission ◽  
Pet Ct ◽  
Thyroid Uptake ◽  
Risk Of Malignancy ◽  
Ct Data ◽  
Fdg Pet Ct

Thyroid incidentalomas detected by 18 fluoro-2-deoxy-d-glucose (FDG)-positron emission tomography/computed tomography (PET/CT) are a real challenge for nuclear medicine physicians and clinicians. This study aimed to evaluate the risk of malignancy for patients with focal thyroid incidentalomas (TIs) diagnosed through FDG PET/CT. Data from 6900 patients, with a known primary tumor, who had an FDG PET/CT investigation performed were analyzed for the presence of incidental thyroid uptake. The focal TIs were reported, and the patients were referred for further investigation to the endocrinology department. There were 126 patients (1.82%) who presented with focal thyroid uptake, and for 87 of them, investigations were completed with ultrasonography (US), and for 29 with a fine needle aspiration biopsy (FNAB) procedure. Malignancy was detected in 7.93% (10/126) of cases. An arbitrary cutoff value of four was established for the standard uptake value lean body mass (SUVlbm Max) to differentiate the malignant nodules from the benign ones, and this value was significantly associated with malignancy (p = 0.0168). TIs are not so frequent, but they have a potential malignancy risk, and a proper evaluation is required. Even though SUVlbm Max is a predictive factor for malignancy, the FNAB remains the main diagnostic method for the therapeutic management of these patients.

scholarly journals COVID-19 and Aspiration Pneumonia: Similar Pulmonary Findings with Different Diagnoses—a Pitfall in [18F]FDG PET/CT

2021 ◽  
Author(s):  
Virginia Liberini ◽  
Serena Grimaldi ◽  
Martin W. Huellner ◽  
Francesca Giunta ◽  
Costanza Bachi ◽  
...  
Keyword(s):  
Case Report ◽  
Severe Acute Respiratory Syndrome ◽  
Aspiration Pneumonia ◽  
Fdg Pet ◽  
Ground Glass Opacity ◽  
Differential Diagnoses ◽  
Ground Glass ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

AbstractSince December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a worldwide pandemic. Especially in the centers most affected by the pandemic, symptoms (such as fever, cough, myalgia, or fatigue) and/or radiological signs (such as ground-glass opacity) typically related to COVID-19 often diverted clinicians’ attention from other diseases. Despite the urgency to recognize and cure SARS-CoV-2 infection, a plethora of differential diagnoses must be considered, and other diseases must be equally and promptly treated, as described in this case report.

scholarly journals Clinical significance of fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography in the follow-up of colorectal cancer: searching off approaches increasing specificity for detection of recurrence

2017 ◽  
Vol 51 (4) ◽  
pp. 378-385 ◽  
Author(s):  
Semra Ince ◽  
Kursat Okuyucu ◽  
Oguz Hancerliogulları ◽  
Engin Alagoz ◽  
Huseyin San ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Fdg Pet ◽  
Emission Tomography ◽  
Positron Emission ◽  
Pet Ct ◽  
Malignant Group ◽  
Fdg Pet Ct ◽  
Benign Group ◽  
Fluorine 18 Fluorodeoxyglucose

AbstractBackgroundNearly 40% of colorectal cancer (CRC) recurs within 2 years after resection of primary tumor. Imaging with fluorine-18-fluorodeoxyglucose (l8F-FDG) positron emission tomography/computed tomography (PET/CT) is the most recent modality and often applied for the evaluation of metastatic spread during the follow-up period. Our goal was to study the diagnostic importance of18F-FDG-PET/CT data of maximum standardized uptake value (SUVmax), total lesion glycolysis (TLG) and the difference of SUVmax on dual-time imaging in CRC.Patients and methodsWe examined the SUVmax value of lesions on control or restaging18F-FDG-PET/CT of 53 CRC patients. All lesions with increased SUVmax values were confirmed by colonoscopy or histopathology. We compared PET/CT results with conventional imaging modalities (CT, MRI) and tumor markers (carbohydrate antigen 19-9 [Ca 19-9], carcinoembryonic antigen [CEA]).ResultsMean SUVmax was 6.9 ± 5.6 in benign group, 12.7 ± 6.1 in malignant group. Mean TLG values of malignant group and benign group were 401 and 148, respectively.18F-FDG-PET/CT was truely positive in 48% of patients with normal Ca 19-9 or CEA levels and truely negative in 10% of cases with elevated Ca 19-9 or CEA. CT or MRI detected suspicious malignancy in 32% of the patients and18F-FDG-PET/CT was truely negative in 35% of these cases. We found the most important and striking statistical difference of TLG value between the groups with benign and recurrent disease.ConclusionsAlthough SUVmax is a strong metabolic parameter (p = 0.008), TLG seems to be the best predictor in recurrence of CRC (p = 0.001); both are increasing the specificity of18F-FDG-PET/CT.

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