scholarly journals Analysis of Long Noncoding RNAs in Aila-Induced Non-Small Cell Lung Cancer Inhibition

2021 ◽  
Vol 11 ◽  
Author(s):  
Lin Chen ◽  
Cui Wu ◽  
Heming Wang ◽  
Sinuo Chen ◽  
Danhui Ma ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Early Stage ◽  
Noncoding Rnas ◽  
Small Cell ◽  
Long Noncoding Rnas ◽  
Dependent Manner ◽  
Small Cell Lung ◽  
Cancer Inhibition

Non-small cell lung cancer (NSCLC) has the highest morbidity and mortality among all carcinomas. However, it is difficult to diagnose in the early stage, and current therapeutic efficacy is not ideal. Although numerous studies have revealed that Ailanthone (Aila), a natural product, can inhibit multiple cancers by reducing cell proliferation and invasion and inducing apoptosis, the mechanism by which Aila represses NSCLC progression in a time-dependent manner remains unclear. In this study, we observed that most long noncoding RNAs (lncRNAs) were either notably up- or downregulated in NSCLC cells after treatment with Aila. Moreover, alterations in lncRNA expression induced by Aila were crucial for the initiation and metastasis of NSCLC. Furthermore, in our research, expression of DUXAP8 was significantly downregulated in NSCLC cells after treatment with Aila and regulated expression levels of EGR1. In conclusion, our findings demonstrate that Aila is a potent natural suppressor of NSCLC by modulating expression of DUXAP8 and EGR1.

Biological functions of long noncoding RNAs and circular RNAs in small-cell lung cancer

Epigenomics ◽  
2020 ◽  
Vol 12 (19) ◽  
pp. 1751-1763
Author(s):  
Sachin Kumar ◽  
Monu Pandey ◽  
Surender K Sharawat
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Noncoding Rnas ◽  
Cancer Biomarkers ◽  
Small Cell ◽  
Long Noncoding Rnas ◽  
Circular Rnas ◽  
Small Cell Lung

We aim to discuss comprehensively the role of long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) in small-cell lung cancer (SCLC) biology and their clinical utility as cancer biomarkers. We searched the scientific literature to select articles related to the role of lncRNAs and circRNAs in SCLC biology or as cancer biomarkers. We identified that a number of lncRNAs and circRNAs can regulate key biological processes involved in SCLC development, including cell proliferation, metastasis and chemoresistance mainly acting as miRNA sponges. Also, the expression of a few lncRNAs and circRNAs predicted survival outcome depicting their utility as prognostic biomarkers. Further investigations on the role of lncRNAs and circRNAs in SCLC tumors may yield novel therapeutic targets for SCLC.

Differential long noncoding RNAs expression in cancer-associated fibroblasts of non-small-cell lung cancer

2019 ◽  
Vol 20 (3) ◽  
pp. 143-153 ◽  
Author(s):  
Cuifang Teng ◽  
Guolin Huang ◽  
Yanmei Luo ◽  
Yingxing Pan ◽  
Hanlin Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Noncoding Rnas ◽  
Small Cell ◽  
Long Noncoding Rnas ◽  
Cancer Associated Fibroblasts ◽  
Small Cell Lung

Long noncoding RNAs: new insights into non-small cell lung cancer biology, diagnosis and therapy

2016 ◽  
Vol 33 (2) ◽  
Author(s):  
Biagio Ricciuti ◽  
Clelia Mencaroni ◽  
Luca Paglialunga ◽  
Francesco Paciullo ◽  
Lucio Crinò ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Cancer Biology ◽  
Noncoding Rnas ◽  
Small Cell ◽  
Long Noncoding Rnas ◽  
Small Cell Lung ◽  
Diagnosis And Therapy

scholarly journals lncINS-IGF2 Promotes Cell Proliferation and Migration by Promoting G1/S Transition in Lung Cancer

2019 ◽  
Vol 18 ◽  
pp. 153303381882302 ◽  
Author(s):  
Shenglan Gao ◽  
Ziying Lin ◽  
Chunyan Li ◽  
Yahong Wang ◽  
Lawei Yang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Noncoding Rnas ◽  
Small Cell ◽  
Long Noncoding Rnas ◽  
Transcript Variant ◽  
Small Cell Lung

Long noncoding RNAs are capable of regulating gene expression at multiple levels. These RNA molecules are also involved in a variety of physiological and pathological processes. Emerging data demonstrate that a series of differentially expressed long noncoding RNAs are implicated in tumorigenesis. In the present study, we used microarray analysis to identify long noncoding RNAs that are dysregulated in non-small-cell lung cancer when compared to normal lung tissues. Accordingly, we performed quantitative real-time polymerase chain reaction to analyze the levels of long noncoding RNA and the cis target gene. We further found the oncogene property of long noncoding RNA that long noncoding RNA downexpression inhibits non-small-cell lung cancer cells proliferation and migration based on 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide and colony formation assays and wound healing as well as transwell assays. The influence of long noncoding RNA on cell cycle of non-small-cell lung cancer cells is also analyzed by flow cytometry. Among the dysregulated long noncoding RNAs, we identified INS-IGF2 readthrough, transcript variant 1, noncoding RNA (NR_003512.3) is upregulated in non-small-cell lung cancer tissues, the cis gene of which is insulin-like growth factor 2 gene hinted by bioinformatics analysis. We also observed that downregulation of INS-IGF2 readthrough, transcript variant 1, noncoding RNA reduces insulin-like growth factor 2 messenger RNA expression. Furthermore, INS-IGF2 readthrough, transcript variant 1, noncoding RNA downregulation suppresses non-small-cell lung cancer cell proliferation and migration. This downregulation results in a concomitant inhibition of the G1/S transition in non-small-cell lung cancer cells. Our findings suggest that INS-IGF2 readthrough, transcript variant 1, noncoding RNA may be an oncogene involved in the development of lung cancer. Therefore, we speculate that INS-IGF2 readthrough, transcript variant 1, noncoding RNA represents a potential therapeutic target for lung cancer.

scholarly journals Long noncoding RNA ANRIL knockdown increases sensitivity of non-small cell lung cancer to cisplatin by regulating the miR-656-3p/SOX4 axis

RSC Advances ◽  
2019 ◽  
Vol 9 (66) ◽  
pp. 38735-38744
Author(s):  
Xianfang Wang ◽  
Jun Shi ◽  
Ying Chen ◽  
Caihong Wang ◽  
Huifang Shi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Noncoding Rnas ◽  
Small Cell ◽  
Long Noncoding Rnas ◽  
Small Cell Lung

Long noncoding RNAs (lncRNAs) are implicated in the development of chemoresistance in many cancers.

Long Noncoding RNAs in Non-Small Cell Lung Cancer: State of the Art

2020 ◽  
pp. 305-325
Author(s):  
Panagiotis Paliogiannis ◽  
Valentina Scano ◽  
Arduino Aleksander Mangoni ◽  
Antonio Cossu ◽  
Giuseppe Palmieri
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
State Of The Art ◽  
Noncoding Rnas ◽  
Small Cell ◽  
Long Noncoding Rnas ◽  
Small Cell Lung

scholarly journals LncRNA CASC2 inhibits autophagy and promotes apoptosis in non-small cell lung cancer cellsviaregulating the miR-214/TRIM16 axis

RSC Advances ◽  
2018 ◽  
Vol 8 (71) ◽  
pp. 40846-40855 ◽  
Author(s):  
Qian Li ◽  
Kai Chen ◽  
Rong Dong ◽  
Hengxiao Lu
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Progression ◽  
Cell Lung Cancer ◽  
Noncoding Rnas ◽  
Small Cell ◽  
Long Noncoding Rnas ◽  
Small Cell Lung

Dysregulated long noncoding RNAs (lncRNAs) have been frequently observed in various cancers including non-small cell lung cancer (NSCLC) and are closely associated with cancer progression.

scholarly journals The prognostic significance of long noncoding RNAs in non-small cell lung cancer: a meta-analysis

Oncotarget ◽  
2016 ◽  
Vol 8 (3) ◽  
pp. 3957-3968 ◽  
Author(s):  
Wei Jing ◽  
Nandi Li ◽  
Yingchao Wang ◽  
Xuefang Liu ◽  
Shengjun Liao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Meta Analysis ◽  
Prognostic Significance ◽  
Noncoding Rnas ◽  
Small Cell ◽  
Long Noncoding Rnas ◽  
Small Cell Lung

Abstract A4: An expression map of long noncoding RNAs in human lung and non-small cell lung cancer

2012 ◽  
Vol 18 (3 Supplement) ◽  
pp. A4-A4
Author(s):  
Daiana D. Becker-Santos ◽  
Ewan E. Gibb ◽  
Emily A. Vucic ◽  
Katey S.S. Enfield ◽  
Greg L. Stewart ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Human Lung ◽  
Noncoding Rnas ◽  
Small Cell ◽  
Long Noncoding Rnas ◽  
Small Cell Lung
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