Case Report: Bilateral Renal Cell Carcinoma With Different Histological and Morphological Features, Clear Cell and Cystic Thyroid-Like Follicular Subtype

Thyroid-like follicular renal cell carcinoma is a rare subtype of renal cell carcinoma that has only been recently recognized, as most cases involve a solid tumor in one kidney. In this study, we report a rare case of bilateral renal cell carcinoma wherein the tumor in the left kidney was diagnosed as clear cell carcinoma, while the tumor in right kidney as thyroid-like follicular renal cell carcinoma. The difference between this case and the ones described in previous reports is that thyroid-like follicular renal cell carcinoma showed cystic changes on imaging. This suggests that when renal cystic lesions are encountered, we should consider the possibility of such rare tumors.

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METASTATIC RENAL CELL CARCINOMA

The Professional Medical Journal ◽

10.29309/tpmj/2009.16.04.2752 ◽

2009 ◽

Vol 16 (04) ◽

pp. 603-605

Author(s):

MALIHE HASANZADEH ◽

ABBAS ALI OMEDE ◽

TARANEH MOHAJERI

Keyword(s):

Renal Cell Carcinoma ◽

Differential Diagnosis ◽

Postmenopausal Woman ◽

Cell Carcinoma ◽

Renal Cell ◽

Rare Case ◽

Renal Mass ◽

Clear Cell ◽

Clear Cell Carcinoma ◽

Radiological Studies

Background: Approximately 30% of patients with renal cell carcinoma present with metastatic disease at the time of diagnosis.Metastasis of renal cell carcinoma to the vagina is rare. Case: A 61 year-old female presented with a vaginal lesion, which was excised anddiagnosed as metastatic clear cell carcinoma. A workup further is done. Radiological studies revealed a left renal mass; A subsequentnephrectomy confirmed renal cell carcinoma. Conclusion: Renal cell carcinoma must be in the differential diagnosis of a vaginal clear cellneoplasm in a postmenopausal woman.

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Metastatic clear cell renal cell carcinoma presenting as breast lump: A rare case report

Diagnostic Cytopathology ◽

10.1002/dc.24710 ◽

2021 ◽

Author(s):

Vikrant Verma ◽

Amrin Israrahmed ◽

Ram N. Rao

Keyword(s):

Renal Cell Carcinoma ◽

Case Report ◽

Cell Carcinoma ◽

Renal Cell ◽

Rare Case ◽

Clear Cell ◽

Breast Lump ◽

Cell Renal Cell Carcinoma ◽

Rare Case Report

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Sarcomatoid Renal Cell Carcinoma of Papillary Origin

Archives of Pathology & Laboratory Medicine ◽

10.5858/2000-124-1830-srccop ◽

2000 ◽

Vol 124 (12) ◽

pp. 1830-1832 ◽

Cited By ~ 2

Author(s):

Ronald J. Cohen ◽

John E. McNeal ◽

Marleen Susman ◽

Loryn N. Sellner ◽

Barry J. Iacopetta ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Clear Cell ◽

Clear Cell Carcinoma ◽

Conclusive Evidence ◽

Clear Cell Tumor ◽

Multiple Copies ◽

Sarcomatoid Renal Cell Carcinoma ◽

Trisomy 7

Abstract Sarcomatoid renal cell carcinoma (SRCC) is an aggressive tumor variant thought to arise predominantly from dedifferentiation of clear cell carcinoma. A few reports of SRCC associated with non–clear cell tumors led to the presumption that SRCC may arise from any renal cell carcinoma, although direct evidence of this is lacking. Cytogenetic studies on 3 previously documented SRCCs associated with papillary renal cancers showed either 3p deletions or absence of trisomy 7, 17 in the sarcomatoid tumors, suggesting origin from a coexistent clear cell tumor. The present case represents the first conclusive evidence of direct progression of non–clear cell carcinoma to SRCC with both tumor components containing multiple copies of chromosomes 7 and 17. Many genetic anomalies, including p53 mutations, frequently recognized in SRCC were not recognized in this case, highlighting the importance of cytogenetic evaluation of all SRCC. The patient is well and without evidence of tumor progression 1 year after surgery, and the sinister outlook of SRCC in association with clear cell carcinoma may not apply in SRCC of non–clear cell origin.

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Unusual presentation of renal cell carcinoma: A rare case report

Journal of Laboratory Physicians ◽

10.4103/jlp.jlp_153_17 ◽

2018 ◽

Vol 10 (02) ◽

pp. 241-244 ◽

Cited By ~ 1

Author(s):

Manjari Kishore ◽

Devender Singh Chauhan ◽

Shruti Dogra

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Clear Cell ◽

Clear Cell Carcinoma ◽

Upper Lip ◽

Rare Case Report ◽

Aggressive Tumor ◽

Oral Tumors ◽

Metastatic Rcc

AbstractCutaneous and intraoral metastasis from any malignancy is not common. Cutaneous spread is usually noted in 5%–10% of high-grade malignancies, as in carcinoma breast, lung, colon, ovary, and malignant melanoma. Only 4.6% cases of cutaneous spread are from renal cell carcinoma (RCC). Intraoral spread from RCC is much rarer with an incidence of approximately 1% of all malignant oral tumors, noted sometimes in tongue, palate, buccal mucosa, gingiva, and lips. RCC is a highly aggressive tumor which requires early diagnosis for increasing the chance of cure. In our case, a 54-year-old male presented with swelling over upper lip, scalp, and retromolar area, which on histopathology and immunohistochemistry revealed clear cell carcinoma compatible with metastatic RCC.

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LRRC19—A Bridge between Selenium Adjuvant Therapy and Renal Clear Cell Carcinoma: A Study Based on Datamining

Genes ◽

10.3390/genes11040440 ◽

2020 ◽

Vol 11 (4) ◽

pp. 440

Author(s):

Yitong Zhang ◽

Jiaxing Wang ◽

Xiqing Liu

Keyword(s):

Gene Expression ◽

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Independent Risk Factor ◽

Clear Cell ◽

Clear Cell Carcinoma ◽

Renal Clear Cell Carcinoma ◽

Cell Renal Cell Carcinoma ◽

Low Expression

Kidney renal clear cell carcinoma (KIRC) is the most common and fatal subtype of renal cancer. Antagonistic associations between selenium and cancer have been reported in previous studies. Selenium compounds, as anti-cancer agents, have been reported and approved for clinical trials. The main active form of selenium in selenoproteins is selenocysteine (Sec). The process of Sec biosynthesis and incorporation into selenoproteins plays a significant role in biological processes, including anti-carcinogenesis. However, a comprehensive selenoprotein mRNA analysis in KIRC remains absent. In the present study, we examined all 25 selenoproteins and identified key selenoproteins, glutathione peroxidase 3 (GPX3) and type 1 iodothyronine deiodinase (DIO1), with the associated prognostic biomarker leucine-rich repeat containing 19 (LRRC19) in clear cell renal cell carcinoma cases from The Cancer Genome Atlas (TCGA) database. We performed validations for the key gene expression levels by two individual clear cell renal cell carcinoma cohorts, GSE781 and GSE6344, datasets from the Gene Expression Omnibus (GEO) database. Multivariate survival analysis demonstrated that low expression of LRRC19 was an independent risk factor for OS. Gene set enrichment analysis (GSEA) identified tyrosine metabolism, metabolic pathways, peroxisome, and fatty acid degradation as differentially enriched with the high LRRC19 expression in KIRC cases, which are involved in selenium therapy of clear cell renal cell carcinoma. In conclusion, low expression of LRRC19 was identified as an independent risk factor, which will advance our understanding concerning the selenium adjuvant therapy of clear cell renal cell carcinoma.

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Renal cell carcinoma: evolving approaches to advanced non-clear cell carcinoma

Oncology Reviews ◽

10.1007/s12156-007-0020-6 ◽

2007 ◽

Vol 1 (3) ◽

pp. 170-176 ◽

Cited By ~ 3

Author(s):

Daniel Y. C. Heng ◽

Ronald M. Bukowski

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Clear Cell ◽

Clear Cell Carcinoma

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Qualitative difference of subcellular localization of tumor-associated carbohydrate (Le(x)) antigens in renal cell carcinoma and normal kidney.

Journal of Histochemistry & Cytochemistry ◽

10.1177/39.4.1672317 ◽

1991 ◽

Vol 39 (4) ◽

pp. 479-484 ◽

Cited By ~ 5

Author(s):

H Ohtani ◽

Y Fukushi ◽

S Orikasa ◽

H Nagura

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Plasma Membranes ◽

Clear Cell ◽

Clear Cell Carcinoma ◽

Intracellular Localization ◽

Qualitative Difference ◽

Ultrastructural Localization ◽

Normal Kidney

Renal cell carcinomas are immunohistochemically positive for oligosaccharides with the Le(x) determinant (Gal beta 1----4[Fuc alpha 1----3]GlcNAc) and its derivatives, as oncofetal antigens, and their expression is closely related to a better prognosis of the patients. This study was designed to clarify the difference in antigen localization at the ultrastructural level between renal cell carcinoma and normal tissues. In normal kidneys, Le(x) detected by monoclonal antibody (MAb) FH 2 and sialylated extended Le(x) (sialyl Le(x)-i) by MAb FH 6 were identified along the plasma membrane of microvilli of proximal tubule epithelial cells, with occasional immunoreactivity along the basolateral plasma membranes. Intracellular localization was very sparse. Renal cell carcinoma showed localization of Le(x) and sialyl Le(x)-i antigens along the cell membrane and in the cytosol as aggregates or filaments. Immunoreactive materials were also observed in the lumen formed among carcinoma cells. The cytosolic immunoreactivity, not observed in the normal kidney, was regarded as "abnormal cytosolic accumulation" of the antigens. This pattern was more pronounced in clear-cell carcinoma. Pretreatment of specimens with chloroform-methanol, which extracts glycolipids, decreased immunoreactivity in carcinoma tissues, particularly that in the cytosol. The extracts contained substances immunoreactive for MAb FH6. Our study has demonstrated that (a) remarkable changes occur in the ultrastructural localization patterns of sialyl Le(x)-i and Le(x) in renal cell carcinoma and (b) considerable amounts of glycolipids are contained in the substances with sialyl Le(x)-i deposited in the cytosol of clear-cell carcinoma.

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Metachronous adrenal metastasis from operated contralateral renal cell carcinoma with adrenalectomy and iatrogenic Addison’s disease

Canadian Urological Association Journal ◽

10.5489/cuaj.2120 ◽

2014 ◽

Vol 8 (9-10) ◽

pp. 744

Author(s):

Hakan Öztürk ◽

Serap Karaaslan

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Radical Nephrectomy ◽

Clear Cell ◽

Clear Cell Carcinoma ◽

Histopathological Examination ◽

Addison’S Disease ◽

Adrenal Metastasis ◽

Addison's Disease

Metachronous adrenal metastasis from contralateral renal cell carcinoma (RCC) surgery is an extremely rare condition. Iatrogenic Addison’s disease occurring after metastasectomy (adrenalectomy) is an even rarer clinical entity. We present a case of a 68-year-old male with hematuria and left flank pain 9 years prior. The patient underwent left transperitoneal radical nephrectomy involving the ipsilateral adrenal glands due to a centrally-located, 75-mm in diameter solid mass lesion in the upper pole of the left kidney. The tumour lesion was confined within the renal capsule, and the histopathological examination revealed a Fuhrman nuclear grade II clear cell carcinoma. The patient underwent transperitoneal right adrenalectomy. The histopathological examination revealed metastasis of clear cell carcinoma. The patient was diagnosed with iatrogenic Addison’s disease based on the measurement of serum cortisol levels and the adrenocorticotropic hormone (ACTH) stimulation test, after which glucocorticoid and mineralocorticoid replacement was initiated. The patient did not have local recurrence or new metastasis in the first year of the follow-up. The decision to perform ipsilateral adrenalectomy during radical nephrectomy constitutes a challenge, and the operating surgeon must consider all these rare factors.

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