Physical and Dosimetric Aspects of the Iridium-Knife

The three-dimensional iridium-192 (192Ir) high-dose-rate (HDR) brachytherapy manifests itself as a high-precision, hypofractionated, dose-escalating, minimally invasive method in the armamentarium of contemporary radiation oncology clinical applications. In this study, the physical aspects of the 192Ir radionuclide are presented. Its dosimetric application in HDR brachytherapy for different anatomical sites (prostate, gynecological malignancies, liver, and intrathoracic tumors) as well as the corresponding dosimetric comparison with the stereotactic body radiation therapy (SBRT) techniques based on a representative selection of dosimetric publications is reviewed and illustrated.

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Stereotactic Body Radiation Therapy (SBRT) Boost to Mimic High-Dose-Rate (HDR) Brachytherapy for Intermediate-Risk Prostate Cancer: A Phase 1 Study

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2014.05.1363 ◽

2014 ◽

Vol 90 (1) ◽

pp. S432 ◽

Cited By ~ 1

Author(s):

A.S. Chiang ◽

D. Loblaw ◽

W. Chu ◽

S. Jain ◽

D. Erler ◽

...

Keyword(s):

Prostate Cancer ◽

Radiation Therapy ◽

Stereotactic Body Radiation Therapy ◽

Phase 1 ◽

High Dose Rate ◽

High Dose ◽

Intermediate Risk ◽

Hdr Brachytherapy ◽

Phase 1 Study ◽

Risk Prostate Cancer

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High Dose Rate Brachytherapy in the Treatment of Companion Animals at a Veterinary Center with Dedicated Iridium-192 HDR Brachytherapy

Brachytherapy ◽

10.1016/j.brachy.2019.04.174 ◽

2019 ◽

Vol 18 (3) ◽

pp. S82-S83

Author(s):

Clayton D. Watkins ◽

John K. Hayes ◽

Joshua A. Bryant ◽

Thomas P. Walsh ◽

Thomas Skidmore

Keyword(s):

Dose Rate ◽

Companion Animals ◽

High Dose Rate ◽

High Dose ◽

Hdr Brachytherapy ◽

High Dose Rate Brachytherapy ◽

Iridium 192

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NCS Report 7: Recommendations for the calibration of Iridium-192 high dose rate sources

10.25030/ncs-07 ◽

1994 ◽

Author(s):

J.L.M. Venselaar ◽

A.H.L. Aalbers ◽

W.F.M. Brouwer ◽

H. Meertens ◽

J.J. Petersen ◽

...

Keyword(s):

Dose Rate ◽

High Dose Rate ◽

High Dose ◽

Iridium 192

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295P High dose rate (HDR) brachytherapy for prostate cancer in the early stages

Annals of Oncology ◽

10.1016/s0923-7534(21)00453-1 ◽

2016 ◽

Vol 27 ◽

pp. ix93

Author(s):

M. Bobkov

Keyword(s):

Prostate Cancer ◽

Dose Rate ◽

High Dose Rate ◽

High Dose ◽

Hdr Brachytherapy ◽

Early Stages

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Interstitial HDR Brachytherapy in the Treatment of Non-Melanocytic Skin Cancers around the Eye

Cancers ◽

10.3390/cancers13061425 ◽

2021 ◽

Vol 13 (6) ◽

pp. 1425

Author(s):

Paweł Cisek ◽

Dariusz Kieszko ◽

Mateusz Bilski ◽

Radomir Dębicki ◽

Ewelina Grywalska ◽

...

Keyword(s):

External Beam Radiotherapy ◽

Late Complication ◽

Target Volume ◽

Lower Eyelid ◽

High Dose Rate ◽

High Dose ◽

Hdr Brachytherapy ◽

Lateral Canthus ◽

Skin Cancers

Background: Eyelid tumors are rare skin cancers, the most common of which is basal cell carcinoma characterized primarily by local growth. In addition to surgery, radiotherapy is among the basic methods of treatment. External beam radiotherapy is associated with the risk of complications within ocular structures, especially the lens. In the case of interstitial brachytherapy, it is possible to administer a high dose to the clinical target volume (CTV), while reducing it in the most sensitive structures. Methods: This paper presents the results of an analysis of 28 patients treated with interstitial high dose rate (HDR) brachytherapy for skin cancers of the upper and lower eyelid; medial and lateral canthus; and the cheek, nose and temples with the infiltration of ocular structures. The patients were treated according to two irradiation schedules: 49 Gy in 14 fractions of 3.5 Gy twice a day for 7 days of treatment, and 45 Gy in 5 Gy fractions twice a day for 5 days. The mean follow-up was 22 months (3–49 months). Results: two patients (6%) had a relapse: a local recurrence within the irradiated area in one of them, and metastases to lymph nodes in the other. The most common early complication was conjunctivitis (74%), and the most common late complication was dry eye syndrome (59%). Conclusions: Interstitial HDR brachytherapy for skin cancers of the upper and lower eyelid; medial and lateral cants; and the cheek, nose and temples with infiltration of ocular structures is a highly effective, short and relatively low burden type of treatment.

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