scholarly journals The Controversy Persists: Is There a Qualification Criterion to Utilize Inhaled Nitric Oxide in Pre-term Newborns?

2021 ◽  
Vol 9 ◽  
Author(s):  
Frederico Vieira ◽  
Marjorie Makoni ◽  
Edgardo Szyld ◽  
Krishnamurthy Sekar
Keyword(s):  
Nitric Oxide ◽  
Perinatal Asphyxia ◽  
Cochrane Review ◽  
Neonatal Resuscitation ◽  
Inhaled Nitric Oxide ◽  
Hypoxemic Respiratory Failure ◽  
Term Infants ◽  
American Academy Of Pediatrics ◽  
Antenatal Steroid ◽  
Term Newborns

Inhaled nitric oxide (iNO) use in premature newborns remains controversial among clinicians. In 2014, the American Academy of Pediatrics, Committee on Fetus and Newborn released a statement that the available data do not support routine iNO use in pre-term newborns. Despite the absence of significant benefits, 2016 California data showed that clinicians continue to utilize iNO in pre-term infants. With studies as recent as January 2017, the Cochrane review confirmed no major advantages of iNO in pre-term newborns. Still, it recognized that a subset of pre-term infants with pulmonary hypertension (PHTN) had not been separately investigated. Furthermore, recent non-randomized controlled trials have suggested that iNO may benefit specific subgroups of pre-term newborns, especially those with PHTN, prolonged rupture of membranes, and antenatal steroid exposure. Those pre-term infants who showed a clinical response to iNO had increased survival without disability. These findings underscore the need for future studies in pre-term newborns with hypoxemic respiratory failure and PHTN. This review will discuss the rationale for using iNO, controversies regarding the diagnosis of PHTN, and additional novel approaches of iNO treatment in perinatal asphyxia and neonatal resuscitation in the pre-term population < 34 weeks gestation.

scholarly journals Longitudinal follow-up in Preterm and Full Term Newborns Treated with Inhaled Nitric Oxide (iNO) for Severely Hypoxemic Respiratory Failure

1999 ◽  
Vol 45 (4, Part 2 of 2) ◽  
pp. 211A-211A
Author(s):  
Jean-Christophe Mercier ◽  
Peter Onody ◽  
Patrick Truffert ◽  
Josefa Llado-Paris ◽  
Anne Clerckx
Keyword(s):  
Nitric Oxide ◽  
Respiratory Failure ◽  
Full Term ◽  
Inhaled Nitric Oxide ◽  
Hypoxemic Respiratory Failure ◽  
Term Newborns

Inhaled nitric oxide in term infants with hypoxemic respiratory failure

1996 ◽  
Vol 129 (2) ◽  
pp. 279-286 ◽  
Author(s):  
Elaine S. Barefield ◽  
Virginia A. Karle ◽  
Joseph B. Philips ◽  
Waldemar A. Carlo
Keyword(s):  
Nitric Oxide ◽  
Respiratory Failure ◽  
Inhaled Nitric Oxide ◽  
Hypoxemic Respiratory Failure ◽  
Term Infants

scholarly journals Inhaled Nitric Oxide Use in Pediatric Hypoxemic Respiratory Failure

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
John T. Berger ◽  
Aline B. Maddux ◽  
Ron W. Reeder ◽  
Russell Banks ◽  
Peter M. Mourani ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Respiratory Failure ◽  
Inhaled Nitric Oxide ◽  
Hypoxemic Respiratory Failure

scholarly journals INHALED NITRIC OXIDE IN COVID-19-INDUCED HYPOXEMIC RESPIRATORY FAILURE

CHEST Journal ◽  
2021 ◽  
Vol 160 (4) ◽  
pp. A1125-A1126
Author(s):  
Siva Naga Yarrarapu ◽  
Abhishek Giri ◽  
Israr Baloch ◽  
Nirmaljot Kaur ◽  
Augustine Lee ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Respiratory Failure ◽  
Inhaled Nitric Oxide ◽  
Hypoxemic Respiratory Failure

scholarly journals Clinical Investigations: Somatosensory Evoked Potentials in Full-Term Neonates With Perinatal Asphyxia

Folia Medica ◽  
2014 ◽  
Vol 56 (2) ◽  
pp. 88-95 ◽  
Author(s):  
Ina E. Geneva ◽  
Maya B. Krasteva ◽  
Stefan S. Kostianev
Keyword(s):  
Evoked Potentials ◽  
Somatosensory Evoked Potentials ◽  
Amplitude Ratio ◽  
Perinatal Asphyxia ◽  
Nerve Fibers ◽  
Full Term ◽  
Healthy Children ◽  
Term Infants ◽  
Healthy Infants ◽  
Term Newborns

Abstract OBJECTIVE: To explore the capacity of somatosensory evoked potentials (SEP) to assess maturation processes in the development of the nervous system, and the characteristics of SEP in healthy full-term infants and full-term newborns with perinatal asphyxia and their follow up until the age of 14 months. MATERIALS AND METHODS: SEP were studied in 21 healthy full-term infants and 38 full-term newborns with perinatal asphyxia. The children with asphyxia were studied longitudinally until they were 14 months old. To assess the SEP we measured the latency of the P15, N20 and P25 components, the amplitude ratio N20/ P25 and inter-peak intervals P15-N20 and N20-P25. RESULTS: The component that was most typically always found in the SEP recordings of both healthy infants and those with perinatal asphyxia was N20. The mean latency values of P15, N20 and P25 were higher in the children with perinatal asphyxia (p ⋋ 0.001). The SEP amplitude was highly variable (CoV% = 76.6%). The latencies became shorter with age in asphyxia patients aged 0 to 14 months, the shortening being the greatest in the first trimester, while they showed no statistically significant differences in infants aged 6 to 12 months. CONCLUSIONS: SEPs in the neonatal period differ considerably from those of adults and older children in the morphology and longer potential latency, which can be accounted for by the incomplete myelination of nerve fibers. The changes in SEP latency in patients with HIE stages I and II follow the same pattern found in healthy children - latency became shorter with increasing age, which was most pronounced in the first 3 months. SEP latency was found to be correlated with height and age. No differences were found in the latency of potentials between healthy infants and infants with brain hemorrhage. Recording SEP is a sensitive method to assess the CNS in children with perinatal asphyxia and to monitor the maturation of the somatosensory pathway.

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