scholarly journals Color Doppler Evaluation of Arterial Resistive Index in Infantile Hemangioma: A Useful Parameter to Monitor the Response to Oral Propranolol?

2021 ◽  
Vol 9 ◽  
Author(s):  
George Koshy Parapatt ◽  
Teresa Oranges ◽  
Guglielmo Paolantonio ◽  
Lucilla Ravà ◽  
Simona Giancristoforo ◽  
...  

Infantile hemangioma (IH) is the most common benign vascular tumor in childhood. In more than 85% of all cases, IHs undergo spontaneous involution, but nearly 10–12% of IHs develop complications and require immediate therapy. Oral propranolol is currently the first-line treatment for IHs. Color Doppler ultrasound is the gold standard in the diagnosis of deep IH, and it is used to evaluate the morphological change and the modification of vascularization that occur during its evolution and treatment. To date, only few data in the literature described the changes of intralesional arterial resistive index (RI) during treatment with propranolol; particularly, some authors have shown an increase of intralesional arterial RI in IHs with clinical regression during treatment with propranolol. The objective of this paper is to evaluate the changes of RI of the intralesional arteries of the IHs during the treatment with oral propranolol. We retrospectively analyzed a total of 64 IHs in 60 patients treated with oral propranolol with a good clinical response. Gray-scale ultrasonography and color Doppler imaging were performed before and during the therapy. The intralesional RIs were measured before and during the treatment. For each lesion, we recorded the RI values, and then we calculated the mean RI value for any single lesion. We compared the mean RI value observed at the baseline with the mean RI value of the last detectable sampling at color Doppler. We also compared between them the mean RI values observed during intermediate ultrasound. The RI values were compared in 44 lesions, with at least two significant samplings of RI. In the 44 lesions compared, we did not find statistically significant variations in the mean RI values between the baseline control and the values recorded at the last post-treatment control. The time trend of mean RI values of the intermediate color Doppler analysis performed between the first pre-treatment control and the last measurable control did not show any statistically significant variation in the trend of mean RI values. Contrarily to what has been described by some authors, in our experience, we have not observed an increase of RI in IHs treated with oral propranolol.

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Fatima Jimenez-Aragon ◽  
Elena Garcia-Martin ◽  
Raquel Larrosa-Lopez ◽  
Jose M. Artigas-Martín ◽  
Pilar Seral-Moral ◽  
...  

This longitudinal and prospective study analyzes the ability of orbital blood flow measured by color Doppler imaging (CDI) to predict glaucoma progression in patients with glaucoma risk factors. Patients with normal perimetry but having glaucoma risk factors and patients in the initial phase of glaucoma were prospectively included in the study and divided, after a five-year follow-up, into two groups: “Progression” and “No Progression” based on the changes in the Moorfields regression analysis (MRA) classification of Heidelberg retina tomograph (HRT). An orbital CDI was performed in all patients and the parameters obtained were correlated with changes in HRT. A logistic discrimination function (LDF) was calculated for ophthalmic artery (OA) and central retinal artery (CRA) parameters. Receiver operating characteristics curves (ROC) were used to assess the usefulness of LDFs to predict glaucomatous progression. A total of 71 eyes were included. End-diastolic velocity, time-averaged velocity, and resistive index in the OA and CRA were significantly different (P<0.05) between the Progression and No Progression groups. The area under the ROC curves calculated for both LDFs was of 0.695 (OA) and 0.624 (CRA). More studies are needed to evaluate the ability of CDI to perform early diagnosis and to predict progression in glaucoma in eyes.


1996 ◽  
Vol 84 (3) ◽  
pp. 459-461 ◽  
Author(s):  
Joanna M. Wardlaw ◽  
James C. Cannon

✓ “Color Doppler energy” (or “power Doppler”), a new color Doppler ultrasound technique that is independent of flow direction and very sensitive to movement, was assessed for its use in the identification of intracranial aneurysms in patients with recent subarachnoid hemorrhage immediately prior to using cerebral angiography. Features that identified aneurysms using this technique included the appearance of abnormal color where no normal artery was expected, abnormal bulging of an artery, and greater “expansibility” of the aneurysm in comparison to an adjacent normal vessel. In this exploratory study, 30 of 33 aneurysms were correctly identified in 35 patients with a good bone window. Color Doppler energy is considerably more sensitive to intracranial blood flow than conventional color Doppler imaging. Color Doppler energy is a useful research tool; if these preliminary results are verified in larger series, in addition to examination for vasospasm, the technique could be used for identification and follow up of aneurysms.


Renal Failure ◽  
2012 ◽  
Vol 34 (6) ◽  
pp. 708-712 ◽  
Author(s):  
Taner Basturk ◽  
Ramazan Albayrak ◽  
Turgay Ulas ◽  
Mehmet Akcay ◽  
Abdulkadir Unsal ◽  
...  

2017 ◽  
Vol 27 (6) ◽  
pp. 751-755 ◽  
Author(s):  
Emine A. Sukgen ◽  
Gökhan Söker ◽  
Yusuf Koçluk ◽  
Bozkurt Gülek

Purpose To evaluate the blood flow changes of the central retinal artery measured with color Doppler imaging (CDI) in infants receiving intravitreal aflibercept (IVA) for treatment of type 1 retinopathy of prematurity (ROP). Methods Patients with type 1 ROP were assessed prospectively by CDI following IVA. Color Doppler imaging was used to measure the peak systolic velocity, end diastolic velocity (EDV), pulsatility index (PI), and resistivity index (RI) of the central retinal artery (CRA) before IVA injection and 1 hour, 1 week, and 1 month after injection. Results A total of 29 eyes of 15 infants were included in this study. The mean gestational age at birth was 28.62 ± 2.48 weeks and the mean birthweight was 1,198.62 ± 348.99 g. All treated eyes showed complete regression of ROP and peripheral retinal vascularization continued. Measurements of EDV-CRA, RI-CRA, and PI-CRA showed significant changes after IVA treatment. Conclusions This study showed that IVA is an effective treatment for type 1 ROP. After IVA treatment, vascular resistance increases, ocular blood flow decreases, and changes in hemodynamic parameters of CRA may remain for a month. Further studies are needed to evaluate the effect of anti-vascular endothelial growth factor agents on ocular hemodynamics in infants with ROP.


2021 ◽  
Vol 18 (2) ◽  
Author(s):  
Marzieh Soleimani ◽  
Seyed Ehsan Ghetmiri ◽  
Mohammad Hossein Ahrar Yazdi

Background: Color Doppler imaging (CDI) is a non-aggressive and safe technique for the clinical management of retinal diseases. Recently, the number of infants with retinopathy of prematurity (ROP) has increased due to the incidence of premature births. Objectives: This study aimed to compare the CDI criteria for the ophthalmic artery (OA) and central retinal artery (CRA) in ROP infants with and without plus disease. Patients and Methods: In this case-control study, 42 premature infants (21 infants with plus disease and 21 infants without plus disease) underwent CDI. The arterial CDI parameters, including end-diastolic velocity (EDV), pulsatility index (PI), resistance index (RI), and peak systolic velocity (PSV), were measured in these patients. After collecting the data, t-test and chi-square tests were used for data analysis. P < 0.05 was considered to be statistically significant. Results: The mean EDV of CRA in patients with and without plus disease was 4.35 ± 1.00 and 5.27 ± 1.02 cm/sec, respectively (P = 0.005). The mean PSV of CRA in patients with and without plus disease was 15.65 ± 3.35 and 18.39 ± 4.39 cm/sec, respectively (P = 0.029). However, no significant difference was found between the two groups in terms of PSV or EDV of OA (P > 0.05). Also, no significant difference was observed between the two groups considering the RI and PI of CRA and OA (P > 0.05). Conclusion: According to the findings of this study, CDI criteria, such as EDV and PSV of CRA, were significantly lower in infants with plus disease as compared to those without plus disease. Since detecting the early stages of plus disease is a challenge for ophthalmologists, assessment of these criteria can be helpful for differentiation of these two subgroups of patients. However, further studies with a larger sample size are needed to determine the cutoff value.


2014 ◽  
Vol 62 (6) ◽  
pp. 671 ◽  
Author(s):  
Ali Akal ◽  
Tugba Goncu ◽  
Ekrem Karakas ◽  
FatimaNurefsan Boyaci ◽  
Abdulgafur Bata ◽  
...  

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Shin Takayama ◽  
Takashi Seki ◽  
Toru Nakazawa ◽  
Naoko Aizawa ◽  
Seri Takahashi ◽  
...  

Background. The relation between glaucoma and retrobulbar circulation in the prognosis has been indicated.Purpose. To investigate the effects of acupuncture on retrobulbar circulation in open-angle glaucoma (OAG) patients.Methods. Eleven OAG patients (20 eyes with OAG) who were treated by topical antiglaucoma medications for at least 3 months were enrolled. Acupuncture was performed once at acupoints BL2, M-HN9, ST2, ST36, SP6, KI3, LR3, GB20, BL18, and BL23 bilaterally. Retrobulbar circulation was measured with color Doppler imaging, and intraocular pressure (IOP) was also measured at rest and one hour after rest or before and after acupuncture.Results. TheΔvalue of the resistive index in the short posterior ciliary artery (P<.01) and theΔvalue of IOP (P<.01) were decreased significantly by acupuncture compared with no acupuncture treatment.Conclusions. Acupuncture can improve the retrobulbar circulation and IOP, which may indicate the efficacy of acupuncture for OAG.


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