scholarly journals Editorial: Cardio-Protection and Heart Repair: New Drugs, Targets and Approaches

2021 ◽  
Vol 12 ◽  
Author(s):  
Naufal Zagidullin ◽  
Benzhi Cai ◽  
Hua Zhu
Keyword(s):  
New Drugs ◽  
Heart Repair ◽  
Cardio Protection

Two isoprenylated flavonoids from Dorstenia psilurus activate AMPK, stimulate glucose uptake, inhibit glucose production and lower glycemia

2019 ◽  
Vol 476 (24) ◽  
pp. 3687-3704 ◽  
Author(s):  
Aphrodite T. Choumessi ◽  
Manuel Johanns ◽  
Claire Beaufay ◽  
Marie-France Herent ◽  
Vincent Stroobant ◽  
...  
Keyword(s):  
Glucose Uptake ◽  
Human Cancer ◽  
Glucose Production ◽  
Liver Mitochondria ◽  
New Drugs ◽  
Structural Isomer ◽  
Rat Liver Mitochondria ◽  
Ionization Mass ◽  
Ampk Activation ◽  
Starting Point

Root extracts of a Cameroon medicinal plant, Dorstenia psilurus, were purified by screening for AMP-activated protein kinase (AMPK) activation in incubated mouse embryo fibroblasts (MEFs). Two isoprenylated flavones that activated AMPK were isolated. Compound 1 was identified as artelasticin by high-resolution electrospray ionization mass spectrometry and 2D-NMR while its structural isomer, compound 2, was isolated for the first time and differed only by the position of one double bond on one isoprenyl substituent. Treatment of MEFs with purified compound 1 or compound 2 led to rapid and robust AMPK activation at low micromolar concentrations and increased the intracellular AMP:ATP ratio. In oxygen consumption experiments on isolated rat liver mitochondria, compound 1 and compound 2 inhibited complex II of the electron transport chain and in freeze–thawed mitochondria succinate dehydrogenase was inhibited. In incubated rat skeletal muscles, both compounds activated AMPK and stimulated glucose uptake. Moreover, these effects were lost in muscles pre-incubated with AMPK inhibitor SBI-0206965, suggesting AMPK dependency. Incubation of mouse hepatocytes with compound 1 or compound 2 led to AMPK activation, but glucose production was decreased in hepatocytes from both wild-type and AMPKβ1−/− mice, suggesting that this effect was not AMPK-dependent. However, when administered intraperitoneally to high-fat diet-induced insulin-resistant mice, compound 1 and compound 2 had blood glucose-lowering effects. In addition, compound 1 and compound 2 reduced the viability of several human cancer cells in culture. The flavonoids we have identified could be a starting point for the development of new drugs to treat type 2 diabetes.

New Drugs Show Promise for CTCL Treatment

2008 ◽  
Vol 39 (9) ◽  
pp. 14-15
Author(s):  
BRUCE JANCIN
Keyword(s):  
New Drugs

Breast cancer: New drugs/regimes

2001 ◽  
Vol 37 ◽  
pp. 145-147
Keyword(s):  
Breast Cancer ◽  
New Drugs

New Drugs on the Horizon for VTE

2005 ◽  
Vol 38 (11) ◽  
pp. 12
Author(s):  
THOMAS WAKEFIELD
Keyword(s):  
New Drugs

New Drugs Scale High-Altitude Pulmonary Edema

2005 ◽  
Vol 38 (19) ◽  
pp. 14
Author(s):  
BRUCE JANCIN
Keyword(s):  
Pulmonary Edema ◽  
High Altitude ◽  
New Drugs ◽  
High Altitude Pulmonary Edema

New Drugs: Lamictal

2003 ◽  
Keyword(s):  
New Drugs

New Drugs Prominent in Rhinitis Guidelines

2008 ◽  
Vol 38 (17) ◽  
pp. 5
Author(s):  
JEFF EVANS
Keyword(s):  
New Drugs
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