scholarly journals Kidney Ischemia/Reperfusion Injury Induces Changes in the Drug Transporter Expression at the Blood–Brain Barrier in vivo and in vitro

2020 ◽  
Vol 11 ◽  
Author(s):  
Malgorzata Burek ◽  
Sandra Burmester ◽  
Ellaine Salvador ◽  
Kerstin Möller-Ehrlich ◽  
Reinhard Schneider ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Blood Brain Barrier ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Brain Barrier ◽  
Drug Transporter ◽  
Blood Brain ◽  
Transporter Expression

Intravenous Fibroblast Growth Factor Penetrates the Blood-Brain Barrier and Protects Hippocampal Neurons Against Ischemia-Reperfusion Injury

1998 ◽  
Vol 49 (1) ◽  
pp. 77-84 ◽  
Author(s):  
Pedro Cuevas M.D., Ph.D., F.A.C.A. ◽  
Fernando Carceller M.D., Ph.D. ◽  
Isabel Muñoz-Willery B.Sc., Ph.D. ◽  
Guillermo Giménez-Gallego B.Sc., Ph.D.
Keyword(s):  
Growth Factor ◽  
Reperfusion Injury ◽  
Fibroblast Growth Factor ◽  
Blood Brain Barrier ◽  
Hippocampal Neurons ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Brain Barrier ◽  
Fibroblast Growth ◽  
Blood Brain

scholarly journals Targeting blood-brain barrier leakage for visualizing , monitoring, and evaluating ischemia reperfusion injury with Rus-Tc99m Probe

2020 ◽  
Author(s):  
Shuaishuai Gong ◽  
Jieman Wang ◽  
Zhuo Chen ◽  
Xuewei Pan ◽  
Yunhao Wu ◽  
...  
Keyword(s):  
Real Time ◽  
Blood Brain Barrier ◽  
Ischemia Reperfusion Injury ◽  
Protective Efficacy ◽  
Ischemia Reperfusion ◽  
In Vitro Study ◽  
Brain Barrier ◽  
Blue Staining ◽  
Blood Brain

Abstract Background : Cerebral ischemia-reperfusion (I/R) injury as a serious threat to human health is characterized by cerebral endothelial leakage, as a result of the damage of blood-brain barrier (BBB). It is thus quite attractive to realize real-time monitoring of BBB damage for therapeutic surveillance.Methods : In this study, a radioactive probe is constructed by conjugating ruscogenin (Rus), a neuroprotectants, to technetium-99m (Tc 99m ) to assess the damage of cerebral endothelial in BBB.Results : In vitro study proves that the probe can penetrate more efficiently in damaged BBB. Then, longitudinal nuclear imaging distinguishes mice with BBB leakage from normal ones, which is validated by evans blue staining of brain tissue. Higher nuclear signal also correlates with poorer blood circulation in brain. Further, by visualizing brain signal during drug treatment, the probe finds that the most obvious protective efficacy of Rus occurs at 12 h post administration, which is superior than edaravone (Edara).Conclusion : Altogether, the probe is promising to monitor I/R injury real-time by radioactive-imaging of BBB integrity. Importantly, Rus as a neuroprotectants may serve as a potential theranostic agent for I/R treatment.

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