scholarly journals Measuring Gaze and Arrow Cuing Effects With a Short Test Adapted to Brain Damaged Patients With Unilateral Spatial Neglect: A Preliminary Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Rindra Narison ◽  
Marie de Montalembert ◽  
Andrew Bayliss ◽  
Laurence Conty
Keyword(s):  
Older Patients ◽  
Brain Lesion ◽  
Brain Lesions ◽  
Spatial Neglect ◽  
Short Version ◽  
Unilateral Spatial Neglect ◽  
Right Brain ◽  
Short Test ◽  
Preliminary Study ◽  
Healthy Participants

People with left unilateral spatial neglect (USN) following a right brain lesion show difficulty in orienting their attention toward stimuli presented on the left. However, cuing the stimuli with gaze direction or a pointing arrow can help some of them to compensate for this difficulty. In order to build a tool that helps to identify these patients, we needed a short version of the paradigm classically used to test gaze and arow cuing effects in healthy adults, adapted to the capacities of patients with severe attention deficit. Here, we tested the robustness of the cuing effects measured by such a short version in 48 young adult healthy participants, 46 older healthy participants, 10 patients with left USN following a right brain lesion (USN+), and 10 patients with right brain lesions but no USN (USN–). We observed gaze and arrow cuing effects in all populations, independently of age and presence or absence of a right brain lesion. In the neglect field, the USN+ group showed event greater cuing effect than older healthy participants and the USN– group. We showed that gaze and arrow cuing effects are powerful enough to be detected in a very short test adapted to the capacities of older patients with severe attention deficits, which increases their applicability in rehabilitation settings. We further concluded that our test is a suitable basis to develop a tool that will help neuropsychologists to identify USN patients who respond to gaze and/or arrow cuing in their neglect field.

scholarly journals Validity and reliability of standing balance control measurement on the left unilateral spatial neglect model

2021 ◽  
Vol 15 (3) ◽  
pp. 167-179
Author(s):  
Abdul C. Meidian ◽  
Song Yige ◽  
Syahmirza I. Lesmana ◽  
Kazu Amimoto
Keyword(s):  
Postural Balance ◽  
Balance Control ◽  
Standing Balance ◽  
Spatial Neglect ◽  
Validity And Reliability ◽  
Control Measurement ◽  
Unilateral Spatial Neglect ◽  
Head Mounted Display ◽  
The Right ◽  
Healthy Participants

BACKGROUND: The present study developed a head-mounted display with the visual direction of a web camera modified to the right as a left unilateral spatial neglect (USN) model with respect to postural balance control. AIM: We aimed to estimate the validity and reliability of center of pressure (CoP) measurements in static standing balance (SSB) and dynamic standing balance (DSB) of healthy participants were using the USN model and to examine whether this model's use influenced postural balance control. METHOD: A portable CoP force plate was used to quantify postural balance control in 64 healthy participants as the model. The CoP displacement of the non-USN and USN models in the medial-lateral (ML) and anterior-posterior (AP) planes, CoP length, and bilateral load ratio in SSB and DSB to the right (R) and left (L) were evaluated. RESULTS: Regression analysis indicated that most CoP measurements have excellent concurrent validity. Bland–Altman plots showed good agreement between the non-USN and USN models in the CoP measurements. Test-retest reliability estimation between two times measurements varied in the frontal and sagittal planes. A Comparison of the results demonstrated that the CoP-AP and CoP length changed (-1.40% and 7.67%, respectively) significantly in SSB (P<0.05). Moreover, the CoP-AP changed very significantly in DSB-R and DSB-L (-1.50% and 1.86%, respectively) in opposite directions (P<0.01) when the subjects performed as the model. CONCLUSION: CoP measurements are valid and reliable to quantify standing balance control in both non-USN and USN models that appear to modulate changes in postural adaptation and adjustment.

Combining Language and Space: Word Bisection in Unilateral Spatial Neglect

2012 ◽  
Author(s):  
Laura Veronelli ◽  
Giuseppe Vallar ◽  
Chiara V. Marinelli ◽  
Silvia Primativo ◽  
Lisa S. Arduino
Keyword(s):  
Spatial Neglect ◽  
Unilateral Spatial Neglect

scholarly journals Structural white-matter connections mediating distinct behavioral components of spatial neglect in right brain-damaged patients

Cortex ◽  
2016 ◽  
Vol 77 ◽  
pp. 54-68 ◽  
Author(s):  
Maarten J. Vaessen ◽  
Arnaud Saj ◽  
Karl-Olof Lovblad ◽  
Markus Gschwind ◽  
Patrik Vuilleumier
Keyword(s):  
White Matter ◽  
Spatial Neglect ◽  
Right Brain

scholarly journals CSF proteome in multiple sclerosis subtypes related to brain lesion transcriptomes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Maria L. Elkjaer ◽  
Arkadiusz Nawrocki ◽  
Tim Kacprowski ◽  
Pernille Lassen ◽  
Anja Hviid Simonsen ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Protein Phosphatase ◽  
Brain Lesion ◽  
Brain Lesions ◽  
Cns Diseases ◽  
Secondary Progressive ◽  
Apolipoprotein A ◽  
Proteomic Approach ◽  
Apolipoprotein C ◽  
Altered Proteins

AbstractTo identify markers in the CSF of multiple sclerosis (MS) subtypes, we used a two-step proteomic approach: (i) Discovery proteomics compared 169 pooled CSF from MS subtypes and inflammatory/degenerative CNS diseases (NMO spectrum and Alzheimer disease) and healthy controls. (ii) Next, 299 proteins selected by comprehensive statistics were quantified in 170 individual CSF samples. (iii) Genes of the identified proteins were also screened among transcripts in 73 MS brain lesions compared to 25 control brains. F-test based feature selection resulted in 8 proteins differentiating the MS subtypes, and secondary progressive (SP)MS was the most different also from controls. Genes of 7 out these 8 proteins were present in MS brain lesions: GOLM was significantly differentially expressed in active, chronic active, inactive and remyelinating lesions, FRZB in active and chronic active lesions, and SELENBP1 in inactive lesions. Volcano maps of normalized proteins in the different disease groups also indicated the highest amount of altered proteins in SPMS. Apolipoprotein C-I, apolipoprotein A-II, augurin, receptor-type tyrosine-protein phosphatase gamma, and trypsin-1 were upregulated in the CSF of MS subtypes compared to controls. This CSF profile and associated brain lesion spectrum highlight non-inflammatory mechanisms in differentiating CNS diseases and MS subtypes and the uniqueness of SPMS.

Sign in / Sign up

Export Citation Format

Share Document