scholarly journals Calcium Imaging in Drug Discovery for Psychiatric Disorders

2020 ◽  
Vol 11 ◽  
Author(s):  
Saurav Seshadri ◽  
Daniel J. Hoeppner ◽  
Katsunori Tajinda
Keyword(s):  
Drug Discovery ◽  
Psychiatric Disorders ◽  
Calcium Imaging

scholarly journals Calcium imaging for analgesic drug discovery

2022 ◽  
pp. 100083
Author(s):  
Federico Iseppon ◽  
John E. Linley ◽  
John N. Wood
Keyword(s):  
Drug Discovery ◽  
Calcium Imaging ◽  
Analgesic Drug

Seeing the light: calcium imaging in cells for drug discovery

2000 ◽  
Vol 5 ◽  
pp. 15-19 ◽  
Author(s):  
Larry C Mattheakis ◽  
Lynne D Ohler
Keyword(s):  
Drug Discovery ◽  
Calcium Imaging ◽  
In Cells

scholarly journals Redesigning antidepressant drug discovery

2014 ◽  
Vol 16 (1) ◽  
pp. 5-7
Keyword(s):  
Drug Discovery ◽  
Animal Models ◽  
Psychiatric Disorders ◽  
Antidepressant Drug ◽  
Diagnostic Process ◽  
Pharmaceutical Companies ◽  
Drug Discovery And Development ◽  
Drug Candidates ◽  
Rapid Transfer ◽  
Efficacy Studies

Antidepressant drug discovery and development have been put on hold by many pharmaceutical companies. The main reason for this is the negative efficacy studies with novel specific drugs. Here I argue that the main obstacles are the absence of gene tests and biomarkers as an integral part of a diagnostic process. Further, too much emphasis has been put on validating drug candidates in animal models of psychiatric disorders. A more rapid transfer of drug candidates into human research is necessary to overcome current obstacles that prevent the discovery of next-generation antidepressants.

5-HT Receptor-Associated Protein Networks: New Targets for Drug Discovery in Psychiatric Disorders?

2012 ◽  
Vol 13 (1) ◽  
pp. 28-52 ◽  
Author(s):  
Philippe Marin ◽  
Carine Becamel ◽  
Aline Dumuis ◽  
Joel Bockaert
Keyword(s):  
Drug Discovery ◽  
Psychiatric Disorders ◽  
Protein Networks ◽  
Receptor Associated Protein ◽  
New Targets
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