scholarly journals The Gilles de la Tourette Syndrome-Quality of Life Scale (GTS-QOL): A Validation in Japanese Patients

2022 ◽  
Vol 12 ◽  
Author(s):  
Ryunosuke Goto ◽  
Natsumi Matsuda ◽  
Maiko Nonaka ◽  
Yu Hamamoto ◽  
Yosuke Eriguchi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Factor Analysis ◽  
Confirmatory Factor Analysis ◽  
Tourette Syndrome ◽  
Goodness Of Fit ◽  
Quality Of Life Scale ◽  
Confirmatory Factor ◽  
Life Scale ◽  
Disease Specific

Background: Though Gilles de la Tourette's syndrome (GTS) has significant impact on the quality of life of its patients, measures of health-related quality of life (HR-QOL) specific to adolescents and adults with GTS were not developed until recently. The present study provides evidence on the validity of the Gilles de la Tourette Syndrome-Quality of Life Scale (GTS-QOL), the first disease-specific HR-QOL instrument for GTS patients, for the first time in an East Asian sample.Methods: One hundred and two Japanese individuals aged 13 and above with GTS were included in our study. Internal consistency was evaluated using Cronbach's alpha. The 4-factor structure of the GTS-QOL was assessed using confirmatory factor analysis, using goodness of fit indices, factor loadings of each questionnaire item, and covariances between factors. Validity was assessed using interscale correlations. Convergent and discriminate construct validity was evaluated using correlations with other scales such as the 28-item General Health Questionnaire, the Yale Global Tic Severity Scale, and the short version of the Padua Inventory.Results: Scaling assumptions were met. Internal consistency reliability was high, with a Cronbach's alpha of 0.96. Confirmatory factor analysis revealed sufficient factor loadings and goodness of fit. All measures of goodness of fit corroborated the fit of the 4-factor model. Standardized covariances between factors in the confirmatory factor analysis were >0.8. There were significant correlations with other well-validated scales, and thus convergent and discriminate construct validity was sufficient.Conclusion: The GTS-QOL is a valid and reliable instrument to measure disease-specific HR-QOL of GTS patients in Japan.

scholarly journals The Gilles De La Tourette Syndrome-Quality of Life Scale for Children and Adolescents (C&A-GTS-QOL): Development and Validation of the Italian Version

2013 ◽  
Vol 27 (1) ◽  
pp. 95-103 ◽  
Author(s):  
Andrea E. Cavanna ◽  
Chiara Luoni ◽  
Claudia Selvini ◽  
Rosanna Blangiardo ◽  
Clare M. Eddy ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Children And Adolescents ◽  
Tourette Syndrome ◽  
Rating Scales ◽  
Self Report ◽  
Principal Component Factor Analysis ◽  
Quality Of Life Scale ◽  
Life Scale ◽  
Disease Specific

Background:Gilles de la Tourette syndrome (GTS) is a chronic childhood-onset neuropsychiatric disorder with a significant impact on patients’ health-related quality of life (HR-QOL). Cavanna et al. (Neurology 2008; 71: 1410–1416) developed and validated the first disease-specific HR-QOL assessment tool for adults with GTS (Gilles de la Tourette Syndrome-Quality of Life Scale, GTS-QOL). This paper presents the translation, adaptation and validation of the GTS-QOL for young Italian patients with GTS.Methods:A three-stage process involving 75 patients with GTS recruited through three Departments of Child and Adolescent Neuropsychiatry in Italy led to the development of a 27-item instrument (Gilles de la Tourette Syndrome-Quality of Life Scale in children and adolescents, C&A-GTS-QOL) for the assessment of HR-QOL through a clinician-rated interview for 6–12 year-olds and a self-report questionnaire for 13–18 year-olds.Results:The C&A-GTS-QOL demonstrated satisfactory scaling assumptions and acceptability. Internal consistency reliability was high (Cronbach’s alpha > 0.7) and validity was supported by interscale correlations (range 0.4–0.7), principal-component factor analysis and correlations with other rating scales and clinical variables.Conclusions:The present version of the C&A-GTS-QOL is the first disease-specific HR-QOL tool for Italian young patients with GTS, satisfying criteria for acceptability, reliability and validity.

The Gilles de la Tourette Syndrome-Quality of Life Scale (GTS-QOL): Development and validation

Neurology ◽  
2008 ◽  
Vol 71 (18) ◽  
pp. 1410-1416 ◽  
Author(s):  
A. E. Cavanna ◽  
A. Schrag ◽  
D. Morley ◽  
M. Orth ◽  
M. M. Robertson ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Tourette Syndrome ◽  
Quality Of Life Scale ◽  
Life Scale ◽  
Development And Validation

scholarly journals Evaluating the measurement properties of the 26-item Expanded Prostate Cancer Index Composite (EPIC-26) with a multicenter cohort

2019 ◽  
Vol 14 (4) ◽  
Author(s):  
R. Trafford Crump ◽  
Alex Peterson ◽  
Camille Charbonneau ◽  
Kevin V. Carlson ◽  
Jason M. Sutherland ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Factor Analysis ◽  
Confirmatory Factor Analysis ◽  
Construct Validity ◽  
Localized Prostate Cancer ◽  
Measurement Properties ◽  
Confirmatory Factor ◽  
Ceiling Effects

Introduction: We aimed to evaluate the psychometric properties of the 26-item Expanded Prostate Cancer Index Composite (EPIC-26) for measuring the quality of life in patients treated for localized prostate cancer. The EPIC-26 is a patient-reported outcome instrument recommended for use with patients treated for localized prostate cancer. Methods: This study is based on data collected prospectively between September 2014 and February 2017 in Alberta, Canada. Men were treated with either radical prostatectomy or radiation therapy and administered the EPIC-26. Responses to the EPIC-26 were the primary outcome. Construct validity was measured using confirmatory factor analysis. Reliability was measured using Chronbach’s alpha and item-total correlation. Ceiling and floor effects were also investigated. Results: EPIC-26 response data from 205 participants (prostatectomy =138; radiation=60; both=7) were used in this analysis. The EPIC-26 was administered an average of 33.8 weeks after treatment. The confirmatory factor analysis model did not meet the threshold for adequate fit. Several items had near-zero factor loadings and were non-significant. Four out of the EPIC- 26’s five domains met the acceptable reliability threshold based on Cronbach’s alpha. Ceiling effects were observed in four out of five domains. Conclusions: The EPIC-26 demonstrated poor construct validity, adequate reliability, and large ceiling effects. Several issues were observed, suggesting that the instrument’s five domains were not well-defined by their respective items. The original EPIC’s conceptual framework should be reviewed and the shortened instrument revised to improve its performance for measuring post-treatment quality of life.

Components of quality of life in a sample of patients with lupus: a confirmatory factor analysis and Rasch modeling of the LupusQoL

2017 ◽  
Vol 36 (8) ◽  
pp. 1789-1795 ◽  
Author(s):  
Ana-Belén Meseguer-Henarejos ◽  
Juan-José Gascón-Cánovas ◽  
José-Antonio López-Pina
Keyword(s):  
Quality Of Life ◽  
Factor Analysis ◽  
Confirmatory Factor Analysis ◽  
Rasch Modeling ◽  
Confirmatory Factor
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