scholarly journals Comparative Studies of the Effects of Two Novel Sugar Drug Candidates on the CYP 1A2 and CYP 2E1 Enzymes in Different Sexed Rats Using a “Cocktail” Approach

Molecules ◽  
2004 ◽  
Vol 9 (11) ◽  
pp. 978-987 ◽  
Author(s):  
Jie Shi ◽  
Mei-Yu Geng ◽  
Chang-Xiao Liu
Keyword(s):  
Comparative Studies ◽  
Drug Candidates ◽  
Cyp 2E1 ◽  
Cyp 1A2 ◽  
Cocktail Approach

Effect of Danggui and Honghua on Cytochrome P450 1A2, 2C11, 2E1 and 3A1 mRNA Expression in Liver of Rats

2008 ◽  
Vol 36 (06) ◽  
pp. 1071-1081 ◽  
Author(s):  
Yan-Hong Li ◽  
Yin-Qing Zhang ◽  
Li Li ◽  
Qing Wang ◽  
Ning-Sheng Wang
Keyword(s):  
Cytochrome P450 ◽  
Prescription Drugs ◽  
Herbal Medicines ◽  
Strong Increase ◽  
Control Group ◽  
Rna Expression ◽  
Water Control ◽  
Alternative Medicines ◽  
Cyp 2E1 ◽  
Cyp 1A2

As alternative medicines or dietary supplements, herbal medicines have received increasing interest in recent years. Danggui and Honghua are two of the most popular traditional Chinese herbal medicines. However, little is known about the pharmacokinetics interactions between Danggui/Honghua and prescription drugs. Therefore, the present study was undertaken to investigate the effect of Danggui or Honghua on the gene expression of cytochrome P450 (CYP) using reverse- transcriptase-polymerase chain reaction (RT-PCR) in Wistar rats. Commercial Danggui (0.35 and 0.7 g/kg, twice a day), Honghua (0.35 g/kg or 0.7 g/kg, twice a day) or water (control group) were given to rats (3 rats for each group) for 5 consecutive days. Treatment of rats with 0.7 and 1.4 g/kg per day Danggui or Honghua for 5 days caused mild to strong increase of CYP 3A1 and decrease of CYP 2E1 RNA expression. However, only Honghua (0.7 and 1.4 g/kg per day) induced the increase of CYP 1A2 RNA expression, while CYP 2C11 RNA was unaffected by both Danggui and Honghua. These data demonstrated that Danggui or Honghua affected the expression of hepatic CYP isoforms in the rats; they elevated CYP 1A2 and 3A1 RNA expression but inhibited CYP 2E1 RNA expression. Such alterations may change the therapeutic actions of the drugs metabolized primarily by P450 system when they are co-administered to people with Danggui or Honghua. Therefore, patients should be cautioned about the potential drug-herb interactions between Danggui or Honghua and prescription drugs that were metabolized by CYP1A2, 2E1 and 3A1 isoforms.

Prevention of acetaminophen (APAP) covalent binding and toxicity in CYP-1A2 and CYP-2E1, double-knockout mice

1998 ◽  
Vol 95 ◽  
pp. 101
Author(s):  
S.D. Cohen ◽  
M.K. Bruno ◽  
H. Zaher ◽  
J.T. Buters ◽  
J.M. Ward ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Covalent Binding ◽  
Double Knockout ◽  
Cyp 2E1 ◽  
Cyp 1A2

Comparative studies of malto- and isomalto-oligasaccharides and their corresponding alditols

1978 ◽  
Vol 60 (2) ◽  
pp. 197-209
Author(s):  
F Schmidt
Keyword(s):  
Comparative Studies

Further Comparative Studies on Ascites in Liver and Heart Disease

1950 ◽  
Vol 16 (1) ◽  
pp. 91-103 ◽  
Author(s):  
John A. Layne ◽  
F.R. Schemm ◽  
W.W. Hurst
Keyword(s):  
Heart Disease ◽  
Comparative Studies

A Reply to Kuder's Criticism of SVIB-KOIS Comparative Studies

1972 ◽  
Vol 5 (1) ◽  
pp. 306-309
Author(s):  
Arthur J. O'Shea ◽  
Mervin D. Lynch ◽  
Thomas F. Harrington
Keyword(s):  
Comparative Studies

Comparative studies of sensory relatedness of odours

1966 ◽  
Author(s):  
Kjell B. Doving ◽  
Anders Lange
Keyword(s):  
Comparative Studies
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