scholarly journals Oxidative Stress and Inflammation in Retinal Degeneration

Antioxidants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 790
Author(s):  
Ravirajsinh Jadeja ◽  
Pamela Martin
Keyword(s):  
Oxidative Stress ◽  
Diabetic Retinopathy ◽  
Retinitis Pigmentosa ◽  
Macular Degeneration ◽  
Retinal Vein Occlusion ◽  
Age Related Macular Degeneration ◽  
Degenerative Diseases ◽  
Vein Occlusion ◽  
Age Related ◽  
And Oxidative Stress

Inflammation and oxidative stress play prominent roles in the pathogenesis of many degenerative diseases of the retina, such as age-related macular degeneration (AMD), diabetic retinopathy (DR), retinal vein occlusion, and retinitis pigmentosa [1–3]. [...]

scholarly journals Update of application of olfactory ensheathing cells and stem cells/exosomes in the treatment of retinal disorders

2022 ◽  
Vol 13 (1) ◽  
Author(s):  
Yang Yu ◽  
Licheng Li ◽  
Shu Lin ◽  
Jianmin Hu
Keyword(s):  
Stem Cells ◽  
Diabetic Retinopathy ◽  
Retinitis Pigmentosa ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Olfactory Ensheathing Cells ◽  
Retinal Diseases ◽  
Age Related ◽  
Retinal Disorders ◽  
Ensheathing Cells

AbstractAge-related macular degeneration, diabetic retinopathy, retinitis pigmentosa and other retinal disorders are the main causes of visual impairment worldwide. In the past, these retinal diseases, especially dry age-related macular degeneration, proliferative diabetic retinopathy and retinitis pigmentosa, were treated with traditional surgery and drugs. However, the effect was moderate. In recent years, researchers have used embryonic stem cells, induced pluripotent stem cells, mesenchymal stem cells, olfactory ensheathing cells and other stem cells to conduct experiments and found that stem cells can inhibit inflammation, regulate immune response, secrete neurotrophic factors, and differentiate into retinal cells to replace and promote restoration of the damaged parts. These stem cells have the potential to treat retinal diseases. Whether it is in animal experiments or clinical trials, the increase in the number of retinal cells, maintenance of function and improvement of visual function all reflect the advanced of stem cells to treat retinal diseases, but its risk preserves the donor’s hidden pathogenic genes, immune rejection and tumorigenicity. With the development of exosomes study, researchers have discovered that exosomes come from a wide range of sources and can be secreted by almost all types of cells. Using exosomes with stem cell to treat retinal diseases is more effective than using stem cells alone. This review article summarizes the recent advances in the application of olfactory ensheathing cells and stem cells/exosomes in the treatment of retinal disorders.

VITREOUS ATTACHMENT IN AGE-RELATED MACULAR DEGENERATION, DIABETIC MACULAR EDEMA, AND RETINAL VEIN OCCLUSION

Retina ◽  
2013 ◽  
Vol 33 (6) ◽  
pp. 1099-1108 ◽  
Author(s):  
Timothy L. Jackson ◽  
Elena Nicod ◽  
Aris Angelis ◽  
Federico Grimaccia ◽  
A. Toby Prevost ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Macular Edema ◽  
Retinal Vein Occlusion ◽  
Diabetic Macular Edema ◽  
Age Related Macular Degeneration ◽  
Vein Occlusion ◽  
Age Related

scholarly journals Involvement of Nrf2 in Ocular Diseases

2017 ◽  
Vol 2017 ◽  
pp. 1-18 ◽  
Author(s):  
Shehzad Batliwala ◽  
Christy Xavier ◽  
Yang Liu ◽  
Hongli Wu ◽  
Iok-Hou Pang
Keyword(s):  
Oxidative Stress ◽  
Diabetic Retinopathy ◽  
Macular Degeneration ◽  
Human Body ◽  
Age Related Macular Degeneration ◽  
Ocular Diseases ◽  
Checks And Balances ◽  
Age Related ◽  
The World

The human body harbors within it an intricate and delicate balance between oxidants and antioxidants. Any disruption in this checks-and-balances system can lead to harmful consequences in various organs and tissues, such as the eye. This review focuses on the effects of oxidative stress and the role of a particular antioxidant system—the Keap1-Nrf2-ARE pathway—on ocular diseases, specifically age-related macular degeneration, cataracts, diabetic retinopathy, and glaucoma. Together, they are the major causes of blindness in the world.

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