Nocardia farcinica Brain Abscess in a Multiple Myeloma Patient Treated with Proteasome Inhibitor: A Case Report and Review of the Literature

Nocardia brain abscess is relatively rare, accounting for about 1–2% of all brain abscesses, and its mortality rate is three times higher than of other types of bacterial brain abscesses; thus, early diagnosis and treatment are essential. Nocardia brain abscess generally occurs in immunodeficient patients. We report a case of Nocardia farcinica brain abscess in a multiple myeloma patient treated with proteasome inhibitor (bortezomib and ixazomib), cyclophosphamide, and corticosteroid. The patient was treated with ceftriaxone and trimethoprim-sulfamethoxazole, together with drainage of the brain abscess. Regular brain MRI follow-ups showed that intracranial lesions were gradually absorbed and improved.

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Brain abscesses caused by Nocardia paucivorans in a multiple myeloma patient treated with lenalidomide and dexamethasone: a case report and review of literature.

Mediterranean Journal of Hematology and Infectious Diseases ◽

10.4084/mjhid.2015.011 ◽

2014 ◽

Vol 7 ◽

pp. e2015011 ◽

Cited By ~ 4

Author(s):

Jacopo Monticelli ◽

Roberto Luzzati ◽

Cristina Maurel ◽

Chiara Rosin ◽

Romina Valentinotti ◽

...

Keyword(s):

Multiple Myeloma ◽

Case Report ◽

Adverse Effects ◽

Infectious Complication ◽

Chemotherapy Regimen ◽

Review Of Literature ◽

Myeloma Patient ◽

Multiple Myeloma Patient ◽

First Case ◽

Brain Abscesses

We report the first case of multiple brain abscesses caused by Nocardia paucivorans in a patient suffering from multiple myeloma on treatment with lenalidomide and dexamethasone. Nocardia paucivorans is a recently described species of the genus Nocardia, which is supposed to have a heightened neurotropism in cases of disseminated infection. Although nocardiosis itself is an uncommon infectious complication in multiple myeloma so far, nocardial brain abscess should be added to the spectrum of adverse effects due to this novel chemotherapy regimen.

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Comparison of the prognostic significance of 5 comorbidity scores and 12 functional tests in a prospective multiple myeloma patient cohort

Cancer ◽

10.1002/cncr.33658 ◽

2021 ◽

Author(s):

Sophia Scheubeck ◽

Gabriele Ihorst ◽

Katja Schoeller ◽

Maximilian Holler ◽

Mandy‐Deborah Möller ◽

...

Keyword(s):

Multiple Myeloma ◽

Prognostic Significance ◽

Functional Tests ◽

Myeloma Patient ◽

Multiple Myeloma Patient ◽

Patient Cohort ◽

Comorbidity Scores

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Abnormal radiological features in a multiple myeloma patient: a case report and radiological review of myelomas

Dentomaxillofacial Radiology ◽

10.1259/dmfr/74265829 ◽

2011 ◽

Vol 40 (8) ◽

pp. 513-518 ◽

Cited By ~ 15

Author(s):

S Ghosh ◽

P Wadhwa ◽

A Kumar ◽

KM Pai ◽

S Seshadri ◽

...

Keyword(s):

Multiple Myeloma ◽

Case Report ◽

Myeloma Patient ◽

Multiple Myeloma Patient ◽

Radiological Features

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AB228. SOH21AS200. A rare case of incidental functioning neck paraganglioma in a multiple myeloma patient

Mesentery and Peritoneum ◽

10.21037/map-21-ab228 ◽

2021 ◽

Vol 5 ◽

pp. AB228-AB228

Author(s):

Waris Ali Shah ◽

Zeeshan Razzaq ◽

Hamid Mustafa ◽

Sarah Lungley ◽

Mohammed Daoud ◽

...

Keyword(s):

Multiple Myeloma ◽

Rare Case ◽

Myeloma Patient ◽

Multiple Myeloma Patient

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Functional Imaging with 18F-FDG PET/CT and Diffusion Weighted Imaging (DWI) in Early Response Evaluation of Combination Therapy of Elotuzumab, Lenalidomide, and Dexamethasone in a Relapsed Multiple Myeloma Patient

Diagnostics ◽

10.3390/diagnostics7040061 ◽

2017 ◽

Vol 7 (4) ◽

pp. 61

Author(s):

Christos Sachpekidis ◽

Antonia Dimitrakopoulou-Strauss ◽

Stefan Delorme ◽

Hartmut Goldschmidt

Keyword(s):

Multiple Myeloma ◽

Diffusion Weighted Imaging ◽

Early Response ◽

Response Evaluation ◽

Myeloma Patient ◽

Multiple Myeloma Patient ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct ◽

And Diffusion

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Brain Abscess and Spinal Epidural Abscess

Mayo Clinic Critical and Neurocritical Care Board Review ◽

10.1093/med/9780190862923.003.0092 ◽

2019 ◽

pp. 642-648

Author(s):

Selby G. Chen

Keyword(s):

Magnetic Resonance Imaging ◽

Brain Abscess ◽

Hospital Admissions ◽

Epidural Abscess ◽

Spinal Epidural Abscess ◽

Early Management ◽

Brain Abscesses ◽

Magnetic Resonance Imaging Mri ◽

Spinal Epidural ◽

The Brain

Two infections of the brain are relatively common. Patients with brain abscess are often critically ill and have a high mortality rate. The reported incidence of brain abscesses ranges from 0.4 to 0.9 per 100,000 people. In contrast, spinal epidural abscess (SEA), an infection of the epidural space, has increased in incidence from approximately 0.2 to 1.2 per 10,000 hospital admissions in the mid-1970s to a currently estimated 2.0 to 12.5 per 10,000 admissions. Both disorders are now more easily detected with magnetic resonance imaging (MRI), and this has improved early management, but clinical recognition is still a challenge for many physicians.

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