scholarly journals Radiation Therapy for Adenoid Cystic Carcinoma of the Head and Neck

Cancers ◽  
2021 ◽  
Vol 13 (24) ◽  
pp. 6335
Author(s):  
Carlos A. Rodriguez-Russo ◽  
Jacqueline C. Junn ◽  
Sue S. Yom ◽  
Richard L. Bakst
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Head And Neck ◽  
Primary Therapy ◽  
Target Delineation ◽  
Treatment Regimens ◽  
Adenoid Cystic ◽  
Patient Morbidity ◽  
Frequent Finding ◽  
Lymphovascular Space Invasion

Adenoid cystic carcinoma of the head and neck is an uncommon malignancy that can arise in the major or minor salivary glands. Perineural invasion (PNI) is an extremely frequent finding in cases of adenoid cystic carcinoma (ACC) that can be associated with significant patient morbidity and poor prognosis. By contrast, ACC rarely demonstrates lymphovascular space invasion thereby making PNI the major avenue for metastasis and a driver of treatment rationale and design. Radiotherapy is often utilized post-operatively to improve locoregional control or as a primary therapy in unresectable disease. Here we aim to review the role of radiotherapy in the management of this malignancy with a focus on target delineation and treatment regimens in the definitive, recurrent, and metastatic settings.

The role of radiotherapy in the management of adenoid cystic carcinoma of the head and neck

1987 ◽  
Vol 13 (8) ◽  
pp. 1135-1141 ◽  
Author(s):  
Junichi Horiuchi ◽  
Hitoshi Shibuya ◽  
Soji Suzuki ◽  
Masamune Takeda ◽  
Minoru Takagi
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Head And Neck ◽  
Adenoid Cystic

The role of elective neck dissection in patients with adenoid cystic carcinoma of the head and neck

2019 ◽  
Vol 129 (9) ◽  
pp. 2094-2104 ◽  
Author(s):  
Roy Xiao ◽  
Rosh K.V. Sethi ◽  
Allen L. Feng ◽  
Joel B. Fontanarosa ◽  
Daniel G. Deschler
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Head And Neck ◽  
Neck Dissection ◽  
Elective Neck Dissection ◽  
Adenoid Cystic

scholarly journals Prognostic Relevance of Thyroid-Hormone-Associated Proteins in Adenoid Cystic Carcinoma of the Head and Neck

2021 ◽  
Vol 11 (12) ◽  
pp. 1352
Author(s):  
Julia Schnoell ◽  
Ulana Kotowski ◽  
Bernhard J. Jank ◽  
Stefan Stoiber ◽  
Elisabeth Gurnhofer ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Adenoid Cystic Carcinoma ◽  
Head And Neck ◽  
Thyroid Hormone Receptor ◽  
Sodium Iodide Symporter ◽  
Protein Levels ◽  
Adenoid Cystic ◽  
Associated Proteins ◽  
Cause Specific Survival

The proteins sodium iodide symporter (NIS), μ-crystallin (CRYM), and thyroid hormone receptor beta (THRB) have been associated with prognosis in various cancer entities. While NIS and THRB may serve as possible therapeutic targets, the role of CRYM in cancer is still unclear. Protein levels of 44 patients with adenoid cystic carcinoma of the head and neck were analyzed using immunohistochemistry and correlated with clinicopathological data and outcome. NIS was positive in 72%, CRYM was positive in 55%, and THRB was positive in 39% of the patients. CRYM-positive adenoid cystic carcinomas were associated with a better cause-specific survival. Thus, our data indicate that CRYM might be a suitable positive prognostic marker in adenoid cystic carcinoma of the head and neck. Furthermore, expression of NIS was present in most patients and therefore evaluation of the use of radioiodine treatment is recommended.

scholarly journals The Role of Particle Therapy in Adenoid Cystic Carcinoma and Mucosal Melanoma of the Head and Neck

2021 ◽  
Vol 8 (1) ◽  
pp. 273-284
Author(s):  
Daniel K. Ebner ◽  
Timothy D. Malouff ◽  
Steven J. Frank ◽  
Masashi Koto
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Head And Neck ◽  
Mucosal Melanoma ◽  
Particle Therapy ◽  
Dose Delivery ◽  
Adenoid Cystic ◽  
Particle Irradiation ◽  
Linear Energy Transfer Radiation ◽  
High Linear Energy Transfer

Abstract Particle irradiation is suitable for resistant histologies owing to a combination of improved dose delivery with potential radiobiologic advantages in high linear energy transfer radiation. Within the head and neck, adenoid cystic carcinoma and mucosal melanoma are two such histologies, being radioresistant and lying closely proximal to critical structures. Here, we review the use of particle irradiation for adenoid cystic carcinoma and mucosal melanoma of the head and neck.

scholarly journals Prognosis and management of recurrent and/or metastatic head and neck adenoid cystic carcinoma

Oral Oncology ◽  
2021 ◽  
Vol 115 ◽  
pp. 105213
Author(s):  
Luigi Lorini ◽  
Laura Ardighieri ◽  
Anna Bozzola ◽  
Chiara Romani ◽  
Eliana Bignotti ◽  
...  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Head And Neck ◽  
Adenoid Cystic

scholarly journals EP-1189 Adenoid Cystic Carcinoma Of The Head And Neck Treated With Carbon Ion Radiotherapy At CNAO

2019 ◽  
Vol 133 ◽  
pp. S659
Author(s):  
M. Bonora ◽  
B. Vischioni ◽  
D. Caivano ◽  
A. Hasegawa ◽  
V. Vitolo ◽  
...  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Head And Neck ◽  
Carbon Ion Radiotherapy ◽  
Carbon Ion ◽  
Adenoid Cystic

scholarly journals Proton Therapy for Head and Neck Adenoid Cystic Carcinoma

2016 ◽  
Vol 96 (2) ◽  
pp. E369-E370
Author(s):  
R.L. Deraniyagala ◽  
C.M. Bryant ◽  
C.G. Morris ◽  
W.M. Mendenhall ◽  
D.J. Indelicato ◽  
...  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Head And Neck ◽  
Proton Therapy ◽  
Adenoid Cystic
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