Asymmetric Michael Addition of Malononitrile with Chalcones via Rosin-Derived Bifunctional Squaramide
Keyword(s):
A rosin-derived bifunctional squaramide catalyzed asymmetric Michael addition of malononitrile with chalcones was discovered. This protocol provides a methodology for the facile synthesis of chiral γ-cyano carbonyl compounds in high yields and enantioselectivities (up to 99% yield and 90% ee) with a lower catalyst loading (0.3 mol%). The predominant R-configured adducts were obtained by this organocatalystic reaction, according to the experimental findings.
2018 ◽
Vol 16
(6)
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pp. 924-935
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2014 ◽
Vol 55
(35)
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pp. 4923-4926
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2012 ◽
Vol 8
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pp. 699-704
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2020 ◽
Vol 18
(8)
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pp. 1647-1656
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