scholarly journals Future Directions in the Treatment of Osteosarcoma

Cells ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 172
Author(s):  
Alannah Smrke ◽  
Peter M. Anderson ◽  
Ashish Gulia ◽  
Spyridon Gennatas ◽  
Paul H. Huang ◽  
...  
Keyword(s):  
Immune Therapy ◽  
Predictive Biomarkers ◽  
Bone Sarcoma ◽  
Future Clinical Trial ◽  
Future Directions ◽  
Immune Therapies ◽  
Primary Bone Sarcoma ◽  
Primary Bone ◽  
Clinical Trial Designs

Osteosarcoma is the most common primary bone sarcoma and is often diagnosed in the 2nd–3rd decades of life. Response to the aggressive and highly toxic neoadjuvant methotrexate-doxorubicin-cisplatin (MAP) chemotherapy schedule is strongly predictive of outcome. Outcomes for patients with osteosarcoma have not significantly changed for over thirty years. There is a need for more effective treatment for patients with high risk features but also reduced treatment-related toxicity for all patients. Predictive biomarkers are needed to help inform clinicians to de-escalate or add therapy, including immune therapies, and to contribute to future clinical trial designs. Here, we review a variety of approaches to improve outcomes and quality of life for patients with osteosarcoma with a focus on incorporating toxicity reduction, immune therapy and molecular analysis to provide the most effective and least toxic osteosarcoma therapy.

scholarly journals Multidisciplinary Management of a Rare Case of a Huge LowGrade Chondrosarcoma of the Lumbar Spine: A Case Report

2020 ◽  
Vol 14 (4) ◽  
pp. 139
Author(s):  
Samuel Jason Rolando Tua ◽  
Hendy Rachmat Primana ◽  
Agus Hadian Rahim ◽  
Ahmad Ramdan ◽  
Herry Herman
Keyword(s):  
Bone Sarcoma ◽  
Tennis Ball ◽  
High Grade ◽  
Low Back ◽  
X Rays ◽  
Comorbid Conditions ◽  
Primary Bone Sarcoma ◽  
Primary Bone ◽  
Viable Treatment

Introduction: Chondrosarcoma is the second most common primary bone sarcoma and arising in the spine. It is estimated to be 2% to 12% in incidence from various series. The use of neoadjuvant and adjuvant chemotherapy for chondrosarcomas is controversial. Low- and intermediate-grade chondrosarcomas respond poorly to chemotherapy. Although not much data on the efficacy of chemotherapy in the treatment of high-grade chondrosarcomas, it should be considered in any young patient with a high-grade tumor. Radiation is recommended when anything other than wide excision is performed for chondrosarcoma of any grade.Case Presentation: A 24-year old female presented to the clinic with a chief complaint of persistent low back pain and a lump in her back. Initially, the lump was the size of a tennis ball three years ago. At the time of the examination, the lump was at the size of a volleyball about 65 x 63 x 58 centimeters. Systemic and general examinations were unremarkable. There were no comorbid conditions. From the results of the Clinicopathological Conference conducted by neurologists, pathologists, radiologists, orthopedic spine and oncology surgeons, it is advisable to conduct investigations such as x-rays, CT scans, MRI, biopsy, and surgery is recommended for evaluation of expansion of chondrosarcoma, evolving the spinal cord, and for resection of tumors.Conclusion: Early diagnosis and complete resection of tumor and treatment of relevant symptoms represent a viable treatment for this rare disorder to achieve increased life expectancy, low recurrence of tumor, and improvement of quality of life.

Longer duration of symptoms at the time of presentation is not associated with worse survival in primary bone sarcoma

2018 ◽  
Vol 100-B (5) ◽  
pp. 652-661 ◽  
Author(s):  
J. M. Lawrenz ◽  
J. F. Styron ◽  
M. Parry ◽  
R. J. Grimer ◽  
N. W. Mesko
Keyword(s):  
Overall Survival ◽  
Proportional Hazards ◽  
Bone Sarcoma ◽  
Axial Skeleton ◽  
Cox Proportional Hazards ◽  
Low Grade ◽  
Duration Of Symptoms ◽  
Negative Effect ◽  
Primary Bone Sarcoma ◽  
Primary Bone

Aims The primary aim of this study was to determine the effect of the duration of symptoms (DOS) prior to diagnosis on the overall survival in patients with a primary bone sarcoma. Patients and Methods In a retrospective analysis of a sarcoma database at a single institution between 1990 and 2014, we identified 1446 patients with non-metastatic and 346 with metastatic bone sarcoma. Low-grade types of tumour were excluded. Our data included the demographics of the patients, the characteristics of the tumour, and the survival outcome of patients. Cox proportional hazards analysis and Kaplan–Meier survival analysis were performed, and the survivorship of the non-metastatic and metastatic cohorts were compared. Results In the non-metastatic cohort, a longer DOS was associated with a slightly more favourable survival (hazard ratio (HR) 0.996, 95% confidence interval (CI) 0.994 to 0.998, p < 0.001). In all types of tumour, there was no difference in survival between patients with a DOS of greater than four months and those with a DOS of less than four months (p = 0.566). There was no correlation between the year of diagnosis and survival (p = 0.741). A diagnosis of chondrosarcoma (HR 0.636, 95% CI 0.474 to 0.854, p = 0.003) had the strongest positive effect on survival, while location in the axial skeleton (HR 1.76, 95% CI 1.36 to 2.29, p < 0.001) had the strongest negative effect on survival. Larger size of tumour (HR 1.05, 95% CI 1.03 to 1.06, p < 0.001) and increased age of the patient (HR 1.02, 95% CI 1.01 to 1.03, p < 0.001) had a slightly negative effect on survival. Metastatic and non-metastatic cohorts had similar median DOS (16 weeks, p = 0.277), although the median survival (15.5 months vs 41 months) and rates of survival at one year (69% vs 89%) and five years (20% vs 59%) were significantly shorter in the metastatic cohort. Conclusion A longer DOS prior to diagnosis is not associated with a poorer overall survival in patients with a primary bone sarcoma. Location in the axial skeleton remains the strongest predictor of a worse prognosis. This may be helpful in counselling patients referred for evaluation on a delayed basis. Cite this article: Bone Joint J 2018;100-B:652–61.

Limb salvage surgery for primary bone sarcoma of the lower extremities: Long-term consequences of endoprosthetic reconstructions

1998 ◽  
Vol 5 (5) ◽  
pp. 423-436 ◽  
Author(s):  
S. John Ham ◽  
Heimen Schraffordt Koops ◽  
René P. H. Veth ◽  
Jim R. van Horn ◽  
Willemina M. Molenaar ◽  
...  
Keyword(s):  
Limb Salvage ◽  
Salvage Surgery ◽  
Lower Extremities ◽  
Bone Sarcoma ◽  
Limb Salvage Surgery ◽  
Primary Bone Sarcoma ◽  
Primary Bone ◽  
Long Term Consequences

A novel combined radiological method for evaluation of the response to chemotherapy for primary bone sarcoma

2012 ◽  
Vol 106 (3) ◽  
pp. 273-279 ◽  
Author(s):  
Shinji Miwa ◽  
Junichi Taki ◽  
Norio Yamamoto ◽  
Toshiharu Shirai ◽  
Hideji Nishida ◽  
...  
Keyword(s):  
Bone Sarcoma ◽  
Radiological Method ◽  
Response To Chemotherapy ◽  
Primary Bone Sarcoma ◽  
Primary Bone

Outcome of pathologic fractures of the proximal femur in nonosteogenic primary bone sarcoma

2011 ◽  
Vol 37 (6) ◽  
pp. 532-536 ◽  
Author(s):  
C.R. Chandrasekar ◽  
R.J. Grimer ◽  
S.R. Carter ◽  
R.M. Tillman ◽  
A.T. Abudu ◽  
...  
Keyword(s):  
Proximal Femur ◽  
Bone Sarcoma ◽  
Pathologic Fractures ◽  
Primary Bone Sarcoma ◽  
Primary Bone

Cost-utility of osteoarticular allograft versus endoprosthetic reconstruction for primary bone sarcoma of the knee: A markov analysis

2017 ◽  
Vol 115 (3) ◽  
pp. 257-265 ◽  
Author(s):  
Robert J. Wilson ◽  
Lina M. Sulieman ◽  
Jacob P. VanHouten ◽  
Jennifer L. Halpern ◽  
Herbert S. Schwartz ◽  
...  
Keyword(s):  
Bone Sarcoma ◽  
Cost Utility ◽  
Endoprosthetic Reconstruction ◽  
Markov Analysis ◽  
Osteoarticular Allograft ◽  
Primary Bone Sarcoma ◽  
Primary Bone

Multifocal Primary Bone Sarcoma in the Elderly: A Rare Case and Review of the Literature

2011 ◽  
Vol 57 (1) ◽  
pp. 1-4 ◽  
Author(s):  
A D Duckworth ◽  
I Beggs ◽  
D M Salter ◽  
J T Patton ◽  
D E Porter
Keyword(s):  
Rare Case ◽  
Bone Sarcoma ◽  
The Elderly ◽  
Review Of The Literature ◽  
Primary Bone Sarcoma ◽  
Primary Bone

scholarly journals Pediatric Chondrosarcoma of the Sternum Resected with Thorascopic Assistance

2017 ◽  
Vol 11 (1) ◽  
pp. 479-485 ◽  
Author(s):  
Harpreet S. Bawa ◽  
Drew D. Moore ◽  
Juan C. Pelayo ◽  
Nicole Cipriani ◽  
Grace Mak ◽  
...  
Keyword(s):  
Chest Wall ◽  
Soft Tissues ◽  
Thoracoscopic Surgery ◽  
Bone Sarcoma ◽  
Wide Resection ◽  
Malignant Neoplasms ◽  
Low Grade ◽  
Orthopaedic Oncology ◽  
Primary Bone Sarcoma ◽  
Primary Bone

Background: Chondrosarcomas are a heterogeneous group of malignant neoplasms that arise from bones, cartilage or other soft tissues that produce cartilage and are commonly seen in the middle decades of life. Despite being the most common primary bone sarcoma in adults, chondrosacromas are rare in pediatric patients. Case Report: We report the case of a six-year-old child with a painless enlarging sternal mass of which biopsy was consistent with low-grade surface chondrosarcoma. This is the first reported case of a chest wall chondrosarcoma in a young child. This unusual location in a young patient presented challenges to treatment. Resection of the manubrium was performed by a multidisciplinary team of orthopaedic oncology and pediatric general surgery. The patient underwent a wide resection of the sternal mass from an anterior approach performed by the orthopaedic oncology team using an oscillating saw under video-assisted thoracoscopic surgery to ensure adequate mass resection without injury to nearby structures. The patient was followed with quarterly physical exams and radiographs for 18 months postoperatively and did not have any pain or evidence of recurrence. Conclusion: Clinicians should consider utilizing multidisciplinary approaches to treat patients with chondrosarcomas of the chest wall.

Primary Bone Sarcoma: The Norwegian Radium Hospital's Material 1932-1937

1942 ◽  
Vol Original Series, Volume 23 (4) ◽  
pp. 387-412
Author(s):  
R. Eker ◽  
E. Poppe
Keyword(s):  
Bone Sarcoma ◽  
Primary Bone Sarcoma ◽  
Primary Bone
Sign in / Sign up

Export Citation Format

Share Document