Cord Blood Platelet Gel as a Treatment of Occipital Pressure Injuries in Newborns: Report of Two Cases

Background: A Pressure Ulcer (PU) is a severe event and could create discomfort to newborns. In newborns, one of mostly stricken location by PU is occipital area. Recent studies have highlighted that Cord Blood Platelet Gel (CBPG) might be a better alternative compared to traditional treatment. We report two cases of occipital PU treated with CBPG. Case report: Two male infants showing occipital PU were treated with standard local treatment, but no improvement was observed. After parental informed consent was obtained, CBPG application on PU was performed every 48 h. In these two cases of PU, a fast improvement in healing was observed since the first application of CBPG. The PU healed resulted in a scar after 53 and 50 days (Case 1 and Case 2, respectively) from development. No complications or infections were reported. Conclusions: CBPG contains many angiogenetic and growth factors, these characteristics make it indicated in treating soft tissue injuries. It would seem to be safe and an effective treatment of neonatal PUs reducing the time of the healing and the hospitalization and the infectious risks. Further studies are needed to evaluate long term aesthetic and functional results of PU treated with CBPG.

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Cord blood platelet gel treatment of dystrophic recessive epidermolysis bullosa

BMJ Case Reports ◽

10.1136/bcr-2014-207364 ◽

2015 ◽

Vol 2015 (jan08 1) ◽

pp. bcr2014207364-bcr2014207364 ◽

Cited By ~ 7

Author(s):

G. Tadini ◽

L. Pezzani ◽

S. Ghirardello ◽

P. Rebulla ◽

S. Esposito ◽

...

Keyword(s):

Cord Blood ◽

Epidermolysis Bullosa ◽

Blood Platelet ◽

Platelet Gel ◽

Gel Treatment

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Use of cord blood platelet gel to enhance healing of deep surgical site dehiscences after peripheral bypass

Regenerative Medicine ◽

10.2217/rme-2020-0034 ◽

2020 ◽

Author(s):

Pietro Volpe ◽

Giulia Pucci ◽

Giuseppe Stilo ◽

Antonino Alberti ◽

Giovanni Foti ◽

...

Keyword(s):

Cord Blood ◽

Outpatient Surgery ◽

Blood Platelet ◽

Major Amputation ◽

Vacuum Assisted Closure ◽

Platelet Gel ◽

Early Graft ◽

Vacuum Assisted Closure Therapy ◽

Early Graft Failure ◽

Subsequent Risk

Surgical site dehiscence after lower limb revascularization through bypass represents a serious postoperative complication, especially in diabetic and obese patients, with subsequent risk of early graft failure, infection, sepsis, hemorrhage, major amputation and sometimes death. To prevent bypass exposure and subsequent complications, physicians recur to reoperation, antibiotic therapy, advanced dressing and vacuum-assisted closure therapy. To improve the process of wound healing, cord blood platelet gel can be used to fill deep and large wounds. Growth factors released from platelets in the cord blood platelet gel stimulate the process of healing and allow patients to be followed up in Outpatient Surgery, thus reducing hospital stay and costs, while providing excellent results.

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The photobiomodulation therapy together with the use of cord blood platelet gel could be safely suggested as primary treatment for oral lesions in patients with inherited epidermolysis bullosa

Photodermatology Photoimmunology & Photomedicine ◽

10.1111/phpp.12548 ◽

2020 ◽

Vol 36 (4) ◽

pp. 318-321 ◽

Cited By ~ 1

Author(s):

Ezio Sindici ◽

Lucia Basiglio ◽

Adriana Cafaro ◽

Luigina Fazio ◽

Antonella Dragonetti ◽

...

Keyword(s):

Cord Blood ◽

Epidermolysis Bullosa ◽

Blood Platelet ◽

Primary Treatment ◽

Photobiomodulation Therapy ◽

Oral Lesions ◽

Platelet Gel ◽

Inherited Epidermolysis Bullosa

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Evaluation of cord blood platelet gel production utilizing low volume cord blood units: the experience of hellenic cord blood bank

Cytotherapy ◽

10.1016/s146532492100551x ◽

2021 ◽

Vol 23 (5) ◽

pp. S161

Author(s):

P. Mallis ◽

Z. Dimou ◽

E. Panagouli ◽

J. Zoidakis ◽

P. Sarri ◽

...

Keyword(s):

Cord Blood ◽

Blood Platelet ◽

Blood Bank ◽

Platelet Gel ◽

Cord Blood Bank ◽

Low Volume

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First endocavitary treatment with cord blood platelet gel for perianal fistula

Regenerative Medicine ◽

10.2217/rme-2019-0074 ◽

2020 ◽

Vol 15 (1) ◽

pp. 1171-1176 ◽

Cited By ~ 1

Author(s):

Giovanni Bisceglia ◽

Michele Santodirocco ◽

Augusta Faienza ◽

Nicola Mastrodonato ◽

Filomena Urbano ◽

...

Keyword(s):

Growth Factors ◽

Cord Blood ◽

Tissue Repair ◽

Perianal Fistula ◽

Blood Platelet ◽

Platelet Concentrate ◽

Liquid Form ◽

Platelet Gel ◽

Deep Cavities

Cord blood platelet gel is prepared by activation of coagulation in a platelet concentrate obtained from cord blood. During the process of clot formation, platelet alpha-granules release growth factors that promote tissue repair. However, in the form of gel, it is not possible to inject it into small, narrow and deep cavities. Therefore, we analyzed gelification kinetics and developed an application technique of platelet gel in liquid form. This semi-activated form provides for the activation of the coagulation process but not the gelification of the platelet concentrate. In this way, it can be easily inoculated in an endocavitary space, and then complete in vivo the gelification process. We report the successful use of this procedure to heal a recurrent perianal fistula.

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Impressive tissue regeneration of severe oral mucositis post stem cell transplantation using cord blood platelet gel

Transfusion ◽

10.1111/trf.14205 ◽

2017 ◽

Vol 57 (9) ◽

pp. 2220-2224 ◽

Cited By ~ 13

Author(s):

Andrea Piccin ◽

Paolo Rebulla ◽

Simonetta Pupella ◽

Mario Tagnin ◽

Giuseppe Marano ◽

...

Keyword(s):

Stem Cell ◽

Stem Cell Transplantation ◽

Cord Blood ◽

Cell Transplantation ◽

Tissue Regeneration ◽

Oral Mucositis ◽

Blood Platelet ◽

Platelet Gel ◽

Severe Oral Mucositis

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The role of the cord blood platelet gel in the management of a diabetic foot with tendon exposure

Regenerative Medicine ◽

10.2217/rme-2021-0044 ◽

2021 ◽

Author(s):

Mafalda Massara ◽

Giulia Pucci ◽

Giuseppe Stilo ◽

Antonino Alberti ◽

Rosangela Surace ◽

...

Keyword(s):

Antibiotic Therapy ◽

Cord Blood ◽

Diabetic Foot ◽

Healing Process ◽

Limb Ischemia ◽

Blood Platelet ◽

Arterial Disease ◽

Diabetic Patients ◽

Platelet Gel ◽

Vital Functions

Diabetic foot infection is frequent in diabetic patients and is due to neuropathy, trauma or peripheral arterial disease. The presence of an abscess requires urgent drainage and specific antibiotic therapy. Patients with critical limb ischemia need revascularization and, subsequently the intervention of a plastic surgeon is often required in cases of exposure of tendons and ligaments. During the COVID-19 pandemic, a patient was refered to our department with an abscess on the dorsum of the left foot. After urgent drainage with tendon exposure, he started specific antibiotic therapy and underwent tibial vessels angioplasty. After infection healing cord blood platelet gel was applied, accelerating the healing process, with injection of its liquid part into the exposed tendons, thus retaining the vital functions of the tendons.

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