scholarly journals Safety and Efficacy of Salvage Neck Dissection Following Carbon-ion Radiotherapy with Chemotherapy for a Patient with Mucosal Malignant Melanoma of Head and Neck

Diagnostics ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 82
Author(s):  
Hidenori Suzuki ◽  
Eiichi Sasaki ◽  
Risa Motai ◽  
Seiya Goto ◽  
Daisuke Nishikawa ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Head And Neck ◽  
Neck Dissection ◽  
Initial Treatment ◽  
Concurrent Chemotherapy ◽  
Carbon Ion Radiotherapy ◽  
Safety And Efficacy ◽  
Carbon Ion ◽  
Mucosal Malignant Melanoma ◽  
Salvage Neck Dissection

Mucosal malignant melanoma of the head and neck is a rare diagnosis. The safety and efficacy of salvage neck dissection following carbon–ion radiotherapy with concurrent chemotherapy are not well described, and carbon–ion radiation protocols have not been fully developed. A 77 year old woman with crT0N1M0 mucosal melanoma of the head and neck achieved a complete response following initial treatment with carbon–ion radiotherapy and concurrent chemotherapy. She was treated with salvage neck dissection for as a cervical lymph node metastasis 16 months after initial treatment. She experienced neither Clavien-Dindo Grade 3 or 4 postoperative complications nor subsequent recurrence of disease at 3 months following salvage neck dissection. Surgical specimens may be useful for future precision oncology based on the molecular biology of recurrence melanoma with poor prognosis.

Mucosal Malignant Melanoma of the Head and Neck Treated by Carbon Ion Radiotherapy

2009 ◽  
Vol 74 (1) ◽  
pp. 15-20 ◽  
Author(s):  
Takeshi Yanagi ◽  
Jun-etsu Mizoe ◽  
Azusa Hasegawa ◽  
Ryo Takagi ◽  
Hiroki Bessho ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Head And Neck ◽  
Carbon Ion Radiotherapy ◽  
Carbon Ion ◽  
Mucosal Malignant Melanoma

Carbon Ion Radiotherapy for Mucosal Malignant Melanoma of the Head and Neck

2005 ◽  
Vol 63 ◽  
pp. S356 ◽  
Author(s):  
K. Kagawa ◽  
H. Mayahara ◽  
Y. Oda ◽  
A. Kawaguchi ◽  
M. Murakami ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Head And Neck ◽  
Carbon Ion Radiotherapy ◽  
Carbon Ion ◽  
Mucosal Malignant Melanoma

scholarly journals Long-term outcomes after carbon ion-radiotherapy for oral mucosal malignant melanoma

2018 ◽  
Vol 64 (4) ◽  
pp. 237-242
Author(s):  
Kensuke NAGANAWA ◽  
Masashi KOTO ◽  
Ryo TAKAGI ◽  
Azusa HASEGAWA ◽  
Hiroaki IKAWA ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Carbon Ion Radiotherapy ◽  
Long Term Outcomes ◽  
Carbon Ion ◽  
Mucosal Malignant Melanoma

scholarly journals Long-term outcomes after carbon-ion radiotherapy for oral mucosal malignant melanoma

2016 ◽  
Vol 58 (4) ◽  
pp. 517-522 ◽  
Author(s):  
Kensuke Naganawa ◽  
Masashi Koto ◽  
Ryo Takagi ◽  
Azusa Hasegawa ◽  
Hiroaki Ikawa ◽  
...  
Keyword(s):  
Overall Survival ◽  
Malignant Melanoma ◽  
Local Control ◽  
Significant Risk ◽  
Carbon Ion Radiotherapy ◽  
Significant Prognostic Factor ◽  
Effective Treatment Option ◽  
Carbon Ion ◽  
Mucosal Malignant Melanoma

Abstract Oral mucosal malignant melanoma (OMM) is extremely rare and has a poor prognosis. Owing to its rarity, it has not yet been possible to establish an optimal treatment modality. The objective of this study was to evaluate the long-term efficacy of carbon-ion radiotherapy (C-ion RT) for OMM. Between 1997 and 2013, 19 patients with OMM were treated with C-ion RT alone. Patient ages ranged from 44 to 84 years (median, 69 years). Nine men and 10 women were included. OMMs were restaged in accordance with the seventh edition of the tumour/node/metastasis (TNM) Staging System of the International Union Against Cancer. Before treatment, 14 patients had T3 disease and 5 had T4a disease. Three patients were classified as having N1 disease. All patients were classified as having M0. The hard palate was the most frequently involved oral subsite. All patients were treated with 57.6 Gy (relative biological effectiveness) in 16 fractions. The median follow-up period was 61 months (range, 8–190 months). The 5-year local control, overall survival and progression-free survival rates were 89.5%, 57.4% and 51.6%, respectively. For local control and overall survival, T classification was found to be a significant prognostic factor. Grade 2 and 3 osteoradionecrosis was observed in three and four patients, respectively. The presence of teeth within the planning target volume was a significant risk factor for developing osteoradionecrosis. C-ion RT was an effective treatment option with acceptable toxicity for OMM.

Carbon Ion Radiotherapy as an Initial Treatment in an Unresectable Head and Neck Soft Tissue Tumor

2011 ◽  
Vol 104 (12) ◽  
pp. 899-903
Author(s):  
Noriko Ogasawara ◽  
Naoki Hyakushima ◽  
Keisuke Kikuchi ◽  
Tomonori Nagaya ◽  
Masao Murakami ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Head And Neck ◽  
Initial Treatment ◽  
Soft Tissue Tumor ◽  
Carbon Ion Radiotherapy ◽  
Carbon Ion ◽  
Tissue Tumor

scholarly journals Oropharyngeal mucosal malignant melanoma successfully treated with carbon ion radiotherapy: A case report

Toukeibu Gan ◽  
2019 ◽  
Vol 45 (1) ◽  
pp. 57-60
Author(s):  
Yusaku Miyata ◽  
Etsuyo Ogo ◽  
Kouichirou Muraki ◽  
Hidetomo Himuro ◽  
Chiyoko Tsuji ◽  
...  
Keyword(s):  
Case Report ◽  
Malignant Melanoma ◽  
Carbon Ion Radiotherapy ◽  
Carbon Ion ◽  
Mucosal Malignant Melanoma
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