scholarly journals Acute Necrotizing Encephalopathy in a Four-Year-Old Boy

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 568
Author(s):  
Cheng-Hsien Tsai ◽  
Wei-Sheng Lin

Acute necrotizing encephalopathy is a devastating clinico-radiological syndrome characterized by fulminant neurological deterioration after an antecedent febrile illness, as well as the imaging hallmark of bilateral thalamic involvement. Herein, we describe a 4-year-old boy with typical clinical and neuroimaging features of acute necrotizing encephalopathy. The bithalamic swelling led to a block of cerebrospinal fluid circulation at the foramen of Monro, thereby causing the mild dilatation of lateral ventricles. The periventricular areas could, therefore, have been potentially affected by the acute necrotizing encephalopathy per se and/or transependymal edema secondary to obstructive hydrocephalus. The information from diffusion imaging allows for differentiation between these two pathophysiological processes.

2011 ◽  
Vol 69 (2a) ◽  
pp. 227-231 ◽  
Author(s):  
Francisco A. Vaz-Guimarães Filho ◽  
Clauder O. Ramalho ◽  
Ítalo C. Suriano ◽  
Samuel T. Zymberg ◽  
Sérgio Cavalheiro

OBJECTIVE: Unilateral hydrocephalus (UH) is characterized by enlargement of just one lateral ventricle. In this paper, the authors will demonstrate their experiences in the neuroendoscopic management of this uncommon type of hydrocephalus. METHOD: The authors retrospectively reviewed a serie of almost 800 neuroendoscopic procedures performed from September 1995 to July 2010 and selected seven adult patients with UH. Clinical and radiological charts were reviewed and analyzed. RESULTS: Six patients had intraventricular neurocysticercosis and one patient had congenital stenosis of the foramen of Monro. Headaches were the most common symptom. A septostomy restored cerebrospinal fluid circulation. During follow-up period (65.5 months, range 3-109) no patient has presented clinical recurrence as well as no severe complications have been observed. CONCLUSION: UH is a rare condition. A successful treatment can be accomplished through a neuroendoscopic approach avoiding the use of ventricular shunts.


Neurosurgery ◽  
2009 ◽  
Vol 64 (3) ◽  
pp. 482-493 ◽  
Author(s):  
Joachim M.K. Oertel ◽  
Henry W.S. Schroeder ◽  
Michael R. Gaab

Abstract OBJECTIVE Although endoscopic perforation of the septum pellucidum in obstruction of the foramen of Monro is well known, detailed reports on endoscopic septostomy, including surgical technique and results are lacking in the literature. METHODS All intracranial endoscopic procedures performed between February 1993 and March 2008 were evaluated. All patients with blockage of the foramen of Monro that was treated with endoscopic septostomy were analyzed and prospectively followed. Particular attention was given to indications, approach, surgical technique, complications, and results. RESULTS Thirty-two endoscopic septostomies were performed in 30 patients (17 male patients, 13 female patients; mean age, 31 years; age range, 4 months–68 years). Cerebrospinal fluid circulation was obstructed by tumor (16 cases), multiloculated cystic hydrocephalus (8 cases, including 2 revisions), septum pellucidum cysts (3 cases), membranous or inflammatory isolated lateral ventricles (3 cases), and giant aneurysms (2 cases). Simultaneously with septostomy, 13 endoscopic tumor procedures, 9 endoscopic third ventriculostomies, and 9 other endoscopic procedures were performed. The mean surgical time was 80 minutes (range, 45–135 minutes). There were 4 asymptomatic complications (13%), 5 transient complications (16%), and no permanent complications. Postoperatively, 26 patients (87%) improved. Two revisions had to be performed. The mean follow-up period was 16 months (range, 1–93 months). CONCLUSION On the basis of the results, long-standing cerebrospinal fluid circulation restoration can be achieved with endoscopic septostomy. Endoscopic septostomy is a safe and reliable endoscopic technique that should be considered more frequently for the restoration of cerebrospinal fluid circulation in the treatment of blockage of the foramen of Monro.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Marie-Hardy Laura ◽  
Cantaut-Belarif Yasmine ◽  
Pietton Raphaël ◽  
Slimani Lotfi ◽  
Pascal-Moussellard Hugues

AbstractCerebrospinal fluid (CSF) circulation relies on the beating of motile cilia projecting in the lumen of the brain and spinal cord cavities Mutations in genes involved in cilia motility disturb cerebrospinal fluid circulation and result in scoliosis-like deformities of the spine in juvenile zebrafish. However, these defects in spine alignment have not been validated with clinical criteria used to diagnose adolescent idiopathic scoliosis (AIS). The aim of this study was to describe, using orthopaedic criteria the spinal deformities of a zebrafish mutant model of AIS targeting a gene involved in cilia polarity and motility, cfap298tm304. The zebrafish mutant line cfap298tm304, exhibiting alteration of CSF flow due to defective cilia motility, was raised to the juvenile stage. The analysis of mutant animals was based on micro-computed tomography (micro-CT), which was conducted in a QUANTUM FX CALIPER, with a 59 µm-30 mm protocol. 63% of the cfap298tm304 zebrafish analyzed presented a three-dimensional deformity of the spine, that was evolutive during the juvenile phase, more frequent in females, with a right convexity, a rotational component and involving at least one dislocation. We confirm here that cfap298tm304 scoliotic individuals display a typical AIS phenotype, with orthopedic criteria mirroring patient’s diagnosis.


Author(s):  
A. Everette James ◽  
Gary R. Novak ◽  
Ernst-Peter Strecker ◽  
Barry B. Burns ◽  
Francisco Correa-Paz ◽  
...  

Stroke ◽  
2017 ◽  
Vol 48 (8) ◽  
pp. 2301-2305 ◽  
Author(s):  
Romain Goulay ◽  
Julien Flament ◽  
Maxime Gauberti ◽  
Michael Naveau ◽  
Nolwenn Pasquet ◽  
...  

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