scholarly journals Prenatal Screening for Developmental Displacement of the Hip: The BUDDHA (Pre-Birth Ultrasound for Developmental Displacement of the Hip Assessment) Study

Diagnostics ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 868
Author(s):  
Elena Contro ◽  
Laura Larcher ◽  
Jacopo Lenzi ◽  
Arianna Benfenati ◽  
Giulia Massinissa Magini ◽  
...  
Keyword(s):  
Normal Development ◽  
Normal Values ◽  
3D Ultrasound ◽  
Tertiary Hospital ◽  
Developmental Dysplasia ◽  
Prenatal Ultrasound ◽  
3D Volume ◽  
Volume Acquisition ◽  
The Buddha ◽  
Dysplasia Of The Hip

Background: developmental dysplasia of the hip has an incidence of 3–5 out of 1000 children. Currently, only postnatal screening is available. Objective: to test the feasibility of a method based on Graf technique application at antenatal ultrasound in assessing the normal development of the hip in unselected term fetuses. Methods: a prospective cohort study in a single university tertiary hospital from January 2017 to January 2020. Single uncomplicated term pregnancies (37–40 weeks) attending our center for routine ultrasound were consecutively recruited for the purpose of the study. A 3D volume acquisition was launched on the coxofemoral joint of the fetus by a single expert operator, and offline analysis was then performed in the multiplanar mode by two operators (blinded to each other analysis) in order to measure the alpha and beta angles according to our modified Graf technique. Intra- and inter-observer variations were calculated. Reference charts for normal values of both angles were produced. Postnatal ultrasound was then performed to measure the Graf angles in newborns, confirming a normal development of the hip. Results: in the study period, 433 uncomplicated term pregnancies underwent 3D ultrasound for the assessment of the fetal hip. One case was subsequently excluded because of confirmed postnatal diagnosis of developmental dysplasia of the hip. The measurement of our modified Graf angles was feasible at prenatal ultrasound with a good reproducibility. The inter-rater and intra-rater reliability of both angles was substantial. Reference charts for normal values of both angles were produced. Conclusions: the evaluation of the coxofemoral joint in fetuses at term of gestation has never been attempted before. The Graf technique application, currently employed at postnatal ultrasound, may also be adapted to prenatal ultrasound with a substantial reproducibility. However, there was no evidence of a linear relationship between prenatal and postnatal alpha angles and beta angles. Further research is needed to establish if developmental dysplasia of the hip could be diagnosed antenatally.

scholarly journals The potential role of the Alsberg angle as a predictor of lateral growth disturbance of the capital femoral epiphysis in children with developmental dysplasia of the hip treated by closed reduction

2020 ◽  
Vol 14 (2) ◽  
pp. 106-111 ◽  
Author(s):  
Ronghua Gui ◽  
Federico Canavese ◽  
Shuang Liu ◽  
Lianyong Li ◽  
Lijun Zhang ◽  
...  
Keyword(s):  
Closed Reduction ◽  
Normal Values ◽  
Developmental Dysplasia ◽  
Lateral Growth ◽  
Growth Disturbance ◽  
Level Of Evidence ◽  
Normal Children ◽  
One Year ◽  
Dysplasia Of The Hip

Purpose Early diagnosis and prevention of lateral growth disturbance of the capital femoral epiphysis is challenging after treatment for developmental dysplasia of the hip (DDH). The aim of the study was to evaluate the radiographic changes of the Alsberg angle (AA) in normal children and those with DDH, and to assess the role of AA as a potential predictor of lateral growth disturbance of the capital femoral epiphysis. Methods AA was measured on the anterior-posterior pelvic radiographs of 1000 normal children ranging in age from one to ten years and in 66 children (92 hips) with DDH treated by closed reduction (CR). A comparative analysis was performed. Results In the normal children, mean AA decreased linearly with age, from 76° at age one year to 65° at age ten years, irrespective of gender and laterality. In children with DDH, the average AA was 81.5°(sd 3.9°; 74° to 87°) prior to CR; it was 75.9° (sd 4.5°; 68° to 83°) in normal children of the same age (p < 0.001). Among the 42 children (64 hips) with successfully and uneventfully treated DDH, AA reached normal values between the ages of five and six years. In contrast, children with lateral growth disturbance of the proximal femur physis (24 children, 28 hips) showed significantly higher AA values in comparison with the age-matched controls. Conclusion In DDH patients with successful CR, AA could be expected to match normal values in children between the ages of five and six years. On the other hand, AA can be used as an early predictor for lateral growth disturbance of the capital femoral epiphysis. Level of Evidence Level III

scholarly journals Effects of abnormal muscle forces on prenatal joint morphogenesis in mice

2019 ◽  
Author(s):  
Vivien Sotiriou ◽  
Rebecca A Rolfe ◽  
Paula Murphy ◽  
Niamh C Nowlan
Keyword(s):  
Skeletal Muscle ◽  
Elbow Joint ◽  
Developmental Disorders ◽  
Normal Development ◽  
Developmental Dysplasia ◽  
Embryonic Mouse ◽  
Fetal Movements ◽  
Muscle Groups ◽  
Joint Shape ◽  
Dysplasia Of The Hip

AbstractFetal movements are essential for normal development of the human skeleton. When fetal movements are reduced or restricted, infants are at higher risk of developmental dysplasia of the hip and arthrogryposis (multiple joint contractures). Joint shape abnormalities have been reported in mouse models with abnormal or absent musculature, but the effects on joint shape in such models have not been quantified or characterised in detail. In this study, embryonic mouse forelimbs and hindlimbs at a single developmental stage (Theiler Stage 23) with normal, reduced or absent muscle were imaged in 3D. Skeletal rudiments were virtually segmented and rigid image registration was used to reliably align rudiments with each other, enabling repeatable assessment and measurement of joint shape differences between normal, reduced-muscle and absent muscle groups. We demonstrate qualitatively and quantitatively that joint shapes are differentially affected by a lack of, or reduction in, skeletal muscle, with the elbow joint being the most affected of the major limb joints. Surprisingly, the effects of reduced muscle were often more pronounced than those of absent skeletal muscle, indicating a complex relationship between muscle mass and joint morphogenesis. These findings have relevance for human developmental disorders of the skeleton in which abnormal fetal movements are implicated, particularly developmental dysplasia of the hip and arthrogryposis.

scholarly journals Characteristics of developmental dysplasia of the hip at a tertiary hospital in Riyadh, Saudi Arabia

2017 ◽  
Vol 5 (2) ◽  
pp. 87 ◽  
Author(s):  
SaifA Al-Saif ◽  
OmarA Al-Mohrej ◽  
WaleedK Alsarhani ◽  
NouraK Al-Ayedh ◽  
AbeerM Al-Ghamdi ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Tertiary Hospital ◽  
Developmental Dysplasia ◽  
Dysplasia Of The Hip

scholarly journals AB130. An audit of screening clinic for developmental dysplasia of the hip in a tertiary hospital

2020 ◽  
Vol 4 ◽  
pp. AB130-AB130
Author(s):  
Karishma Seomangal ◽  
Nauman Saeed ◽  
Khalid Khan ◽  
Amir Siddiqui
Keyword(s):  
Tertiary Hospital ◽  
Developmental Dysplasia ◽  
Screening Clinic ◽  
Dysplasia Of The Hip

scholarly journals Using 3D Ultrasound to Improve Reliability in Assessing Developmental Dysplasia of the Hip

10.29007/74v9 ◽  
2018 ◽  
Author(s):  
Niamul Quader ◽  
Antony J. Hodgson ◽  
Kishore Mulpuri ◽  
Anthony Cooper ◽  
Emily Schaeffer ◽  
...  
Keyword(s):  
3D Ultrasound ◽  
Developmental Dysplasia ◽  
Significant Variability ◽  
2D Ultrasound ◽  
Dysplasia Of The Hip ◽  
Improve Reliability

Many infants are born with unstable hips which can cause severe mobility issues as they grow older. This condition is known as developmental dysplasia of the hip (DDH), and although it is the most common hip disorder in infants, its diagnosis using 2D ultrasound (US) is prone to significant variability. This paper presents methods to reliably and automatically diagnose DDH in infants using 3D US. Based on 40 infant hip examinations, we demonstrate a 70% reduction in variability of 3D US-based measurements compared to those of standard 2D US-based measurements.

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