scholarly journals Splenosis Mimicking Peritoneal Seeding of Advanced Colon Cancer Can Be Identified by Spleen SPECT/CT and FDG PET/CT

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1045
Author(s):  
Ji Young Lee ◽  
Hee-Sung Song ◽  
Jimin Han
Keyword(s):  
Computed Tomography ◽  
Colon Cancer ◽  
Fdg Pet ◽  
Treatment Plan ◽  
Photon Emission ◽  
Hepatic Metastases ◽  
Emission Computed Tomography ◽  
Peritoneal Seeding ◽  
Pet Ct ◽  
Fdg Pet Ct

This case report demonstrates that Tc-99m labeled heat-damaged red blood cell single-photon emission computed tomography/computed tomography (spleen SPECT/CT) and F-18 fluorodeoxyglucose positron emission tomography/CT (FDG PET/CT) could noninvasively confirm splenosis mimicking peritoneal seeding of advanced sigmoid colon cancer with hepatic metastases, and played a crucial role in determining the treatment plan.

scholarly journals Multiple Vertebral Hemangiomas Mimicking Metastases in a Patient with Renal Carcinoma: Importance of Hybrid Imaging with SPECT/CT and FDG PET/CT

2012 ◽  
Vol 46 (4) ◽  
pp. 196-197
Author(s):  
BR Mittal ◽  
A Bhattacharya ◽  
K Manohar ◽  
RVR Parghane ◽  
S Kumari ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Fdg Pet ◽  
Hybrid Imaging ◽  
Renal Carcinoma ◽  
Photon Emission ◽  
Benign Tumors ◽  
Emission Computed Tomography ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Vertebral Hemangiomas

ABSTRACT Vertebral hemangiomas are the most common benign tumors of the spine and usually present as cold defects on skeletal scintigraphy. However, these lesions may rarely show uptake of Tc-99m methylene diphosphonate, mimicking metastases. In this patient with renal carcinoma, abnormal vertebral tracer uptake (indicative of skeletal metastases on planar bone scintigraphy) was subsequently localized to vertebral lesions identified as hemangiomas on the CT component of single photon emission computed tomography/computed tomography (SPECT/CT). None of these hemangiomas showed any uptake of F-18 fluorodeoxyglucose on positron emission tomography/ computed tomography (PET/CT). How to cite this article Manohar K, Parghane RVR, Kumari S, Bhattacharya A, Mandal AK, Mittal BR. Multiple Vertebral Hemangiomas Mimicking Metastases in a Patient with Rena Carcinoma: Importance of Hybrid Imaging with SPECT/CT and FDG PET/CT. J Postgrad Med Edu Res 2012;46(4):196-197.

Eosinophilic Infiltration in the Colon and Liver Mimicking Primary Colon Cancer With Hepatic Metastases on 18F-FDG PET/CT

2013 ◽  
Vol 38 (6) ◽  
pp. 471-473 ◽  
Author(s):  
Il Jo ◽  
Kyoung Sook Won ◽  
Byung Wook Choi ◽  
Sung Hoon Kim ◽  
Seok Kil Zeon
Keyword(s):  
Colon Cancer ◽  
Fdg Pet ◽  
Hepatic Metastases ◽  
Eosinophilic Infiltration ◽  
Pet Ct ◽  
Primary Colon Cancer ◽  
Primary Colon ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Diagnostic and Clinical Impact of 18F-FDG PET/CT in Staging and Restaging Soft-Tissue Sarcomas of the Extremities and Trunk: Mono-Institutional Retrospective Study of a Sarcoma Referral Center

2020 ◽  
Vol 9 (8) ◽  
pp. 2549
Author(s):  
Alessio Annovazzi ◽  
Sandra Rea ◽  
Carmine Zoccali ◽  
Rosa Sciuto ◽  
Jacopo Baldi ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Soft Tissue ◽  
Fdg Pet ◽  
Soft Tissue Sarcomas ◽  
Emission Computed Tomography ◽  
Therapy Planning ◽  
Histologic Subtype ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Background: Soft-tissue sarcomas (STS) represent a wide heterogeneous class of rare tumors. The exact role 18F-fluorodeoxyglucose positron emission/computed tomography (18F-FDG PET/CT) in the evaluation of STS is not well established. The aim of the present study was to evaluate how the use of 18F-FDG PET/CT in STS could influence patient therapy planning, looking for a possible added value over computed tomography and magnetic resonance imaging—the most used modalities in the study of STS. Differences in SUVmax according to histologic subtype and tumor grade were also considered. Methods: a total of 345 consecutive 18F-FDG PET/CT scans performed for initial staging (n = 171) or for suspected disease relapse (n = 174) in 282 patients with STS extracted from the local Information System database were retrospectively reviewed. Results: 18F-FDG PET/CT altered therapy planning in 80 cases (16.4% for staging and 29.9% in restaging), both for disease upstaging (58.8%) and downstaging (41.2%) Conclusions: 18F-FDG PET/CT could significantly influence management of patients with STS, particularly for restaging.

scholarly journals Added value of 18F-FDG-PET/CT and cardiac CTA in suspected transcatheter aortic valve endocarditis

2019 ◽  
Author(s):  
Ali R. Wahadat ◽  
Wilco Tanis ◽  
Laurens E. Swart ◽  
Asbjørn Scholtens ◽  
Gabriel P. Krestin ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Aortic Valve ◽  
Fdg Pet ◽  
Final Diagnosis ◽  
Emission Computed Tomography ◽  
Cardiac Computed Tomography Angiography ◽  
Cardiac Cta ◽  
Duke Criteria ◽  
Pet Ct ◽  
Fdg Pet Ct

Abstract Backgrounds Transcatheter-implanted aortic valve infective endocarditis (TAVI-IE) is difficult to diagnose when relying on the Duke Criteria. Our aim was to assess the additional diagnostic value of 18F-fluorodeoxyglucose (18F-FDG) positron emission/computed tomography (PET/CT) and cardiac computed tomography angiography (CTA) in suspected TAVI-IE. Methods A multicenter retrospective analysis was performed in all patients who underwent 18F-FDG-PET/CT and/or CTA with suspected TAVI-IE. Patients were first classified with Duke Criteria and after adding 18F-FDG-PET/CT and CTA, they were classified with European Society of Cardiology (ESC) criteria. The final diagnosis was determined by our Endocarditis Team based on ESC guideline recommendations. Results Thirty patients with suspected TAVI-IE were included. 18F-FDG-PET/CT was performed in all patients and Cardiac CTA in 14/30. Using the Modified Duke Criteria, patients were classified as 3% rejected (1/30), 73% possible (22/30), and 23% definite (7/30) TAVI-IE. Adding 18F-FDG-PET/CT and CTA supported the reclassification of 10 of the 22 possible cases as “definite TAVI-IE” (5/22) or “rejected TAVI-IE” (5/22). This changed the final diagnosis to 20% rejected (6/30), 40% possible (12/30), and 40% definite (12/30) TAVI-IE. Conclusions Addition of 18F-FDG-PET/CT and/or CTA changed the final diagnosis in 33% of patients and proved to be a valuable diagnostic tool in patients with suspected TAVI-IE.

scholarly journals Σχεδιασμός και ανάπτυξη συστήματος υπολογιστικής ευφυΐας για την εκτίμηση κινδύνου σε παθήσεις που σχετίζονται με το καρδιαγγειακό σύστημα

2021 ◽  
Author(s):  
Παύλος Καφούρης
Keyword(s):  
Computed Tomography ◽  
Myocardial Perfusion ◽  
Fdg Pet ◽  
Single Photon ◽  
Photon Emission ◽  
Standardized Uptake Value ◽  
Flow Reserve ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Σύμφωνα με τον Παγκόσμιο Οργανισμό Υγείας οι καρδιαγγειακές παθήσεις, μεταξύ αυτών ιδιαίτερα η αθηρωματική στεφανιαία νόσος, είναι η συχνότερη αιτία θανάτου παγκοσμίως. Σκοπός αυτής της διδακτορικής διατριβής ήταν η ανάλυση ψηφιακών δεδομένων προερχομένων κυρίως από ιατρικές εικόνες, αλλά και από βιολογικά δείγματα, ασθενών με καρδιαγγειακές παθήσεις, με σκοπό την ανάδειξη σημαντικών βιοδεικτών για τις εν λόγω οντότητες. Κομβικό ρόλο στην επίλυση των ερευνητικών ερωτημάτων της παρούσας διατριβής κατέχει η μηχανική μάθηση, μέσω αλγορίθμων ταξινόμησης και παλινδρόμησης, αλλά και η αυτόνομη εφαρμογή που αναπτύχθηκε, ικανή να εκτελεί ανάγνωση και προσαρμοσμένη οπτικοποίηση των εικόνων τομογραφίας εκπομπής ποζιτρονίων (Positron Emission Tomography, PET)/αξονικής τομογραφίας (Computed Tomography, CT), μέσω της οποίας μελετήθηκαν και αναλύθηκαν τα ερωτήματα που πραγματεύθηκαν στη διατριβή. Αρχικά, μελετήθηκε η μεταβολή της πρόσληψης του ραδιοφαρμάκου στο αρτηριακό δίκτυο με την πάροδο του χρόνου και υλοποιήθηκαν προβλεπτικά μοντέλα εκτίμησης των μετρήσεων προτυποποιημένης τιμής πρόσληψης (standardized uptake value, SUV) σε διαφορετικές χρονικές στιγμές (Τ1, Τ2). Συλλέχτηκαν βιοϊατρικά δεδομένα 45 ατόμων που δεν είχαν κάποια ασθένεια όταν υποβλήθηκαν σε Φθοριοδεσοξυγλυκόζη (Fluorodeoxyglucose, 18F-FDG) PET/CT απεικόνιση. Αναπτύχθηκαν γραμμικά και μη γραμμικά μοντέλα παλινδρόμησης της διαφοράς του SUV (ΔSUV) και της χρονικής διαφοράς ΔΤ=Τ2-Τ1, βασιζόμενα στην ομάδα παραγωγής (30 ασθενείς) και ελέγχθηκαν σε μία ανεξάρτητη ομάδα επικύρωσης (15 ασθενείς). Τα μοντέλα παρουσίασαν πολύ καλή επαναληψιμότητα, με μικρές μη στατιστικώς σημαντικές διαφορές, πιθανώς περιορισμένης κλινικής σημασίας, μεταξύ του πραγματικού και του προβλεπόμενου SUV. Ένα άλλο επιστημονικό ερώτημα που προσεγγίστηκε στην παρούσα διατριβή, ήταν η ανάδειξη βιοδεικτών για την πρόβλεψη αθηρωματικής νόσου. Σε δύο διαφορετικά σύνολα ασθενών, με υψηλού βαθμού στένωση καρωτίδας και έχοντας υποβληθεί σε καρωτιδική ενδαρτηρεκτομή, μελετήθηκε η ανάλυση υφής για πρώτη φορά στη 18F-FDG PET/CT καρωτιδική απεικόνιση (1ο σύνολο) και η ανάλυση δεδομένων γονιδιακής έκφρασης από μικροσυστοιχίες δειγμάτων καρωτιδικής ενδαρτηρεκτομής μέσου και έξω χιτώνα του αγγειακού τοιχώματος από τον πυρήνα της αθηρωματικής πλάκας και από μακροσκοπικά υγιή ιστό (2ο σύνολο), τα οποία πάρθηκαν από τη διαδικτυακή βάση δεδομένων Gene Expression Omnibus (GEO). Σαν απεικονιστικοί βιοδείκτες εξήχθησαν 16 χαρακτηριστικά βάσει ιστογράμματος έντασης και 51 χαρακτηριστικά που βασίζονται σε διάφορους αναλυτικούς πίνακες που ήδη κωδικοποιούν συγκεκριμένες χωρικές σχέσεις μεταξύ των εικονοστοιχείων και χαρακτηρίζουν τη χωρική ετερογένεια. Τα διαφορικώς εκφρασμένα γονίδια (Differentially Expressed Genes, DEGs) ταξινομήθηκαν βάσει της απόλυτης τιμής του log Fold Change (logFC) και χρησιμοποιήθηκαν μεμονωμένα ως είσοδοι σε ταξινομητές με σκοπό την ανάδειξή τους σε πιθανούς βιοδείκτες. Μετά την ανάλυση των δεδομένων, μέσω αλγορίθμων μηχανικής μάθησης, αποδείχθηκε ότι η ανάλυση υφής μπορεί να χρησιμοποιηθεί σε συνδυασμό με την αγγειακή απεικόνιση ΡΕΤ και ενδεχομένως να παρέχει πολύτιμες συμπληρωματικές πληροφορίες σε σύγκριση με το λόγο πρόσληψης 18F-FDG της υπό εξέτασης ανατομικής δομής προς το αίμα (target to background ratio, TBR) σχετικά με τα βιολογικά χαρακτηριστικά της πλάκας που ενδέχεται να μη διακρίνονται από το ανθρώπινο μάτι. Παράλληλα, εντοπίστηκαν κρίσιμα γονίδια που εμπλέκονται στην ανάπτυξη της αθηροσκλήρωσης της καρωτίδας και μπορεί να αποτελούν πολύτιμοι θεραπευτικοί στόχοι και δείκτες πρόβλεψης για την αθηροσκλήρωσή της. Στη συνέχεια, διερευνήθηκε η ικανότητα αλγορίθμων μηχανικής μάθησης στην πρόβλεψη μεταβολών μυοκαρδιακής αιμάτωσης (myocardial perfusion) μέσω PET και τομογραφίας μονοφωτονιακής εκπομπής (Single Photon Emission Computer Tomography, SPECT) απεικόνισης, ενσωματώνοντας παραμέτρους που εξάγονται από τις εικόνες υπολογιστικής τομογραφίας στεφανιαίων αγγείων (Computed Tomography Coronary Angiography, CTCA), όπως την υπολογιστική δυναμική ρευστού, το φορτίο αθηρωματικής πλάκας, τη μορφολογία και τα ανατομικά χαρακτηριστικά αυτής, καθώς και χαρακτηριστικά υφής, εκτιμώμενης ως εφεδρεία στεφανιαίας ροής μυοκαρδίου (myocardial flow reserve, MFR) ή ως ροή αίματος μυοκαρδίου (myocardial blood flow, MBF). Τα αποτελέσματα έδειξαν ότι η μηχανική μάθηση φαίνεται να είναι αποτελεσματική στην πρόβλεψη παθολογικής μυοκαρδιακής αιμάτωσης. Μεταξύ των καλύτερων συνδυασμών χαρακτηριστικών, η ενδοθηλιακή διατμητική τάση (endothelial shear stress, ESS) στο εγγύς τμήμα ήταν το χαρακτηριστικό που εμφανίστηκε στις πρώτες θέσεις σε όλα τα σχήματα ταξινόμησης. Επιπλέον, η ανατομία της πλάκας και οι συνακόλουθες αλλαγές στη δυναμική του υγρού, όπως καταγράφονται από τo ESS, φαίνεται να είναι σημαντικοί πληροφοριακοί δείκτες για τη λειτουργική σημασία μιας στεφανιαίας βλάβης. Επιπλέον, τo ESS μπορεί να προσθέσει αξία στη σοβαρότητα της στένωσης, βελτιώνοντας την πρόβλεψη της εξασθενημένης αγγειοδιασταλτικής ικανότητας που αξιολογείται από το ΡΕΤ-ΜΡΙ (Myocardial Perfusion Imaging – απεικόνιση αιμάτωσης του μυοκαρδίου). Η ανάλυση υφής μπορεί να χρησιμοποιηθεί σε συνδυασμό με την απεικόνιση CTCA και ενδεχομένως να παρέχει πολύτιμες συμπληρωματικές πληροφορίες σε συνδυασμό με ανατομικά και μορφολογικά χαρακτηριστικά για την πρόβλεψη επαγώγιμων ανωμαλιών αιμάτωσης στο SPECT-MPI, οι οποίες ενδέχεται να μην συλλαμβάνονται από το ανθρώπινο μάτι.

Computerized Tomography (CT) Updates and Challenges in Diagnosis of Bone Metastases During Prostate Cancer

2020 ◽  
Vol 16 (5) ◽  
pp. 565-571
Author(s):  
Jinguo Zhang ◽  
Guanzhong Zhai ◽  
Bin Yang ◽  
Zhenhe Liu
Keyword(s):  
Prostate Cancer ◽  
Computed Tomography ◽  
Bone Metastases ◽  
Computerized Tomography ◽  
Single Photon ◽  
Photon Emission ◽  
Major Complication ◽  
Tracer Uptake ◽  
Emission Computed Tomography ◽  
Pet Ct

Prostate cancer is one of the most common cancers in men. This cancer is often associated with indolent tumors with little or no lethal potential. Some of the patients with aggressive prostate cancer have increased morbidity and early deaths. A major complication in advanced prostate cancer is bone metastasis that mainly results in pain, pathological fractures, and compression of spinal nerves. These complications in turn cause severe pain radiating to the extremities and possibly sensory as well as motor disturbances. Further, in patients with a high risk of metastases, treatment is limited to palliative therapies. Therefore, accurate methods for the detection of bone metastases are essential. Technical advances such as single-photon emission computed tomography/ computed tomography (SPECT/CT) have emerged after the introduction of bone scans. These advanced methods allow tomographic image acquisition and help in attenuation correction with anatomical co-localization. The use of positron emission tomography/CT (PET/CT) scanners is also on the rise. These PET scanners are mainly utilized with 18F-sodium-fluoride (NaF), in order to visualize the skeleton and possible changes. Moreover, NaF PET/CT is associated with higher tracer uptake, increased target-to-background ratio and has a higher spatial resolution. However, these newer technologies have not been adopted in clinical guidelines due to lack of definite evidence in support of their use in bone metastases cases. The present review article is focused on current perspectives and challenges of computerized tomography (CT) applications in cases of bone metastases during prostate cancer.

FDG-PET/CT Assessment of Pulmonary Sarcoidosis: A Guide for Internists

2018 ◽  
Vol 15 (1) ◽  
pp. 21-25 ◽  
Author(s):  
Marco Tana ◽  
Silvio di Carlo ◽  
Marcello Romano ◽  
Massimo Alessandri ◽  
Cosima Schiavone ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Fdg Pet ◽  
Correct Diagnosis ◽  
Pulmonary Sarcoidosis ◽  
High Resolution Computed Tomography ◽  
Inflammatory Conditions ◽  
Positron Emission ◽  
Pet Ct ◽  
Noncaseating Granulomas ◽  
Fdg Pet Ct

Background:18F-fluorodeoxyglucose positron emission tomography integrated with computed tomography (18-F-FDG-PET/CT) is getting wide consensus in the diagnosis and staging of neoplastic disorders and represents a useful tool in the assessment of various inflammatory conditions. </P><P> Discussion: Sarcoidosis is an uncommon disease characterized by the systemic formation of noncaseating granulomas. Lungs are the sites most often affected, and investigation with high resolution computed tomography and biopsy is essential to achieve a correct diagnosis. 18-F-FDGPET/ CT is effective in the assessment of pulmonary sarcoidosis by demonstrating pulmonary and extrathoracic involvement and findings correlate well with pulmonary function in patients affected.Conclusion:This review would illustrate the usefulness and limits of 18-F-FDG-PET/CT in the assessment of pulmonary sarcoidosis.

scholarly journals A Nordic survey of CT doses in hybrid PET/CT and SPECT/CT examinations

2019 ◽  
Vol 6 (1) ◽  
Author(s):  
Natalie A. Bebbington ◽  
Bryan T. Haddock ◽  
Henrik Bertilsson ◽  
Eero Hippeläinen ◽  
Ellen M. Husby ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Single Photon Emission ◽  
Positron Emission ◽  
Pet Ct ◽  
Clinical Purpose ◽  
Single Photon Emission Computed ◽  
Photon Emission Computed Tomography

Abstract Background Computed tomography (CT) scans are routinely performed in positron emission tomography (PET) and single photon emission computed tomography (SPECT) examinations globally, yet few surveys have been conducted to gather national diagnostic reference level (NDRL) data for CT radiation doses in positron emission tomography/computed tomography (PET/CT) and single photon emission computed tomography/computed tomography (SPECT/CT). In this first Nordic-wide study of CT doses in hybrid imaging, Nordic NDRL CT doses are suggested for PET/CT and SPECT/CT examinations specific to the clinical purpose of CT, and the scope for optimisation is evaluated. Data on hybrid imaging CT exposures and clinical purpose of CT were gathered for 5 PET/CT and 8 SPECT/CT examinations via designed booklet. For each included dataset for a given facility and scanner type, the computed tomography dose index by volume (CTDIvol) and dose length product (DLP) was interpolated for a 75-kg person (referred to as CTDIvol,75kg and DLP75kg). Suggested NDRL (75th percentile) and achievable doses (50th percentile) were determined for CTDIvol,75kg and DLP75kg according to clinical purpose of CT. Differences in maximum and minimum doses (derived for a 75-kg patient) between facilities were also calculated for each examination and clinical purpose. Results Data were processed from 83 scanners from 43 facilities. Data were sufficient to suggest Nordic NDRL CT doses for the following: PET/CT oncology (localisation/characterisation, 15 systems); infection/inflammation (localisation/characterisation, 13 systems); brain (attenuation correction (AC) only, 11 systems); cardiac PET/CT and SPECT/CT (AC only, 30 systems); SPECT/CT lung (localisation/characterisation, 12 systems); bone (localisation/characterisation, 30 systems); and parathyroid (localisation/characterisation, 13 systems). Great variations in dose were seen for all aforementioned examinations. Greatest differences in DLP75kg for each examination, specific to clinical purpose, were as follows: SPECT/CT lung AC only (27.4); PET/CT and SPECT/CT cardiac AC only (19.6); infection/inflammation AC only (18.1); PET/CT brain localisation/characterisation (16.8); SPECT/CT bone localisation/characterisation (10.0); PET/CT oncology AC only (9.0); and SPECT/CT parathyroid localisation/characterisation (7.8). Conclusions Suggested Nordic NDRL CT doses are presented according to clinical purpose of CT for PET/CT oncology, infection/inflammation, brain, PET/CT and SPECT/CT cardiac, and SPECT/CT lung, bone, and parathyroid. The large variation in doses suggests great scope for optimisation in all 8 examinations.

scholarly journals An Unusual Case of Primary Hyperparathyroidism: Case Report of a Bifocal Intrathyroidal Parathyroid Carcinoma

2020 ◽  
pp. 014556132097746
Author(s):  
Maxime Damien ◽  
Alexandra Rodriguez ◽  
Pierre Kleynen ◽  
Didier Dequanter ◽  
Cyril Bouland
Keyword(s):  
Computed Tomography ◽  
Primary Hyperparathyroidism ◽  
Parathyroid Carcinoma ◽  
Photon Emission ◽  
Parathyroid Tissue ◽  
Emission Computed Tomography ◽  
Thyroid Lobe ◽  
Imaging Results ◽  
Pet Ct ◽  
Left Thyroid Lobe

Intrathyroidal parathyroid carcinoma is an extremely rare cause of primary hyperparathyroidism. We reported a 51-year old woman who presented symptoms of hypercalcemia. 99mTc sestamibi single-photon emission computed tomography/computed tomography (CT) revealed a large hypermetabolic nodule in the left thyroid lobe suggestive of hyperfunctioning parathyroid tissue. 11C-methionine positron emission tomography/computed tomography (PET/CT) and 18F-fluorocholine PET/CT confirmed the nodule in the left thyroid lobe and also revealed a hypermetabolic activity on the posterior surface of the lower left pole. The patient underwent a total thyroidectomy and parathyroidectomy, and a diagnosis of bifocal intrathyroidal parathyroid carcinoma was confirmed. We present the first reported case of bifocal intrathyroidal carcinoma and discuss the discordant imaging results.

POSITRON EMISSION TOMOGRAPHY WITH 18F -FDG IN THE DIAGNOSIS OF PROSTHETIC HEART VALVE ENDOCARDITIS

2021 ◽  
Vol 5 (1) ◽  
pp. 1151-1160
Author(s):  
A.S. Lukashevich ◽  
Keyword(s):  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Fdg Pet ◽  
Prosthetic Heart Valve ◽  
Emission Tomography ◽  
Whole Body ◽  
Positron Emission ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Purpose. The purpose of the article is to evaluate the diagnostic significance of positron emission tomography / computed tomography with 18F -fluorodeoxyglucose (18F -FDG PET/CT) for the diagnosis of prosthetic endocarditis. Methods of research. The study included 82 patients with suspected prosthetic endocarditis in accordance with the criteria proposed by Duke University [1-5]. The patients received hospital treatment at the State Institution RSPC "Cardiology" from January 2016 to March 2021. The study was of a prospective, non-randomized, single-center cohort design. The duration of the monitor period was 12 months from the moment of patients’ inclusion in the study. Whole-body positron emission tomography / computed tomography (PET/CT) examinations were performed in 82 patients. 27 patients were selected for surgical treatment. Conservative treatment group included 16 patients. 27 patients were selected into the observation group, they were suspected to have prosthetic heart valve infection in the primary referral and underwent PET/CT scanning, according to which the diagnosis of prosthetic endocarditis was excluded. The event under the study did not develop in this group during the year of observation. Results and conclusion. The history of infective endocarditis was not statistically significant and did not increase the risk of developing prosthetic endocarditis in the sample presented. The Duke criteria are less reliable in establishing the diagnosis of prosthetic endocarditis. The median number of days from the date of the first prosthesis implantation to the onset of prosthetic endocarditis was about 4 years. This study revealed that the development of the infectious process in the area of the prosthesis was noted in a more distant postoperative period compared to literature data. Histological confirmation of infection was noted in 100% (27 patients) of cases in reoperated patients. The presence of a more formidable complication such as valve ring abscess located mainly in the projection of the aortic valve ring was quite common in both groups. Presepsin and Interleukin-6 have a statistically significant (U = 394,50 p = 0,01 and U = 94,50 p = 0.004) value in the prognosis of prosthetic endocarditis. Considering the data obtained from ROC analysis, it can be said that the cut-off point at which it is possible to diagnose prosthetic endocarditis based on PETCT is 2.85. The presented methods for the interpretation of whole-body FDG-PET/CT images of patients with suspected infectious complications after cardiac surgery, as well as with the presence of prosthetic endocarditis, show high sensitivity and specificity.

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