scholarly journals Whole-Body MRI in Rheumatology: Major Advances and Future Perspectives

Diagnostics ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1770
Author(s):  
Luca Deplano ◽  
Matteo Piga ◽  
Michele Porcu ◽  
Alessandro Stecco ◽  
Jasjit S. Suri ◽  
...  
Keyword(s):  
Pediatric Population ◽  
Standard Technique ◽  
Chronic Recurrent Multifocal Osteomyelitis ◽  
Whole Body ◽  
Whole Body Mri ◽  
Treatment Response Evaluation ◽  
Multifocal Osteomyelitis ◽  
Body Magnetic Resonance Imaging ◽  
Juvenile Spondyloarthritis

Whole-body magnetic resonance imaging is constantly gaining more importance in rheumatology, particularly for what concerns the diagnosis, follow-up, and treatment response evaluation. Initially applied principally for the study of ankylosing spondylitis, in the last years, its use has been extended to several other rheumatic diseases. Particularly in the pediatric population, WB-MRI is rapidly becoming the gold-standard technique for the diagnosis and follow-up of both chronic recurrent multifocal osteomyelitis and juvenile spondyloarthritis. In this review, we analyze the benefits and limits of this technique as well as possible future applications.

scholarly journals Whole-body MRI in the diagnosis of paediatric CNO/CRMO

Rheumatology ◽  
2020 ◽  
Vol 59 (10) ◽  
pp. 2671-2680 ◽  
Author(s):  
Savvas Andronikou ◽  
Jeannette K Kraft ◽  
Amaka C Offiah ◽  
Jeremy Jones ◽  
Hassan Douis ◽  
...  
Keyword(s):  
Chronic Recurrent Multifocal Osteomyelitis ◽  
Bisphosphonate Therapy ◽  
Whole Body ◽  
Inflammatory Disorder ◽  
Whole Body Mri ◽  
Spine Imaging ◽  
Multifocal Osteomyelitis ◽  
Hands And Feet ◽  
Short Tau Inversion Recovery

Abstract Chronic recurrent multifocal osteomyelitis (CRMO) is an auto-inflammatory disorder affecting the skeleton of children and adolescents. Whole-body MRI (WBMRI) is key in the diagnosis and follow-up of CRMO. Imaging protocols should include sagittal short Tau inversion recovery of the spine, imaging of the hands and feet, and T1 images for distinguishing normal bone marrow. CRMO lesions can be metaphyseal, epiphyseal and physeal—potentially causing growth disturbance and deformity. Spinal lesions are common, important and can cause vertebral collapse. Lesion patterns include multifocal tibial and pauci-focal patterns that follow a predictable presentation and course of disease. Common pitfalls of WBMRI include haematopoietic marrow signal, metaphyseal signal early on in bisphosphonate therapy and normal high T2 signal in the hands and feet. Pictorial reporting assists in recording lesions and follow-up over time. The purpose of this paper is to review the different WBMRI protocols, imaging findings, lesion patterns and common pitfalls in children with CRMO

scholarly journals Whole body MRI in the diagnosis of chronic recurrent multifocal osteomyelitis

2012 ◽  
Vol 98 (4) ◽  
pp. 461-464 ◽  
Author(s):  
M.T. Kennedy ◽  
T. Murphy ◽  
M. Murphy ◽  
E. Laffan ◽  
P. Connolly
Keyword(s):  
Chronic Recurrent Multifocal Osteomyelitis ◽  
Whole Body ◽  
Whole Body Mri ◽  
Multifocal Osteomyelitis

scholarly journals Whole-body MRI Imaging Is an Essential Tool in Diagnosing and Monitoring Patients With Sterile Osteomyelitis

2021 ◽  
pp. jrheum.201507
Author(s):  
Takashi Shawn Sato ◽  
Polly J. Ferguson
Keyword(s):  
Bone Pain ◽  
Chronic Recurrent Multifocal Osteomyelitis ◽  
Whole Body ◽  
Mri Imaging ◽  
Whole Body Mri ◽  
Diagnostic Odyssey ◽  
Essential Tool ◽  
Multifocal Osteomyelitis

From the first description in 1972 as “subacute and chronic recurrent osteomyelitis” to the currently recognized chronic recurrent multifocal osteomyelitis (CRMO) or chronic nonbacterial osteitis (CNO), diagnosis and monitoring of patients with this disease has been and continues to be a challenge1,2. While the most common presenting symptom is focal bone pain, its waxing and waning nature tends to contribute to the diagnostic odyssey that many patients must endure.

Chronic recurrent multifocal osteomyelitis: the value of whole-body MRI in a series of 34 children

2015 ◽  
Author(s):  
Benjamin Jacobs ◽  
Mathew Brown ◽  
Ananya Guha ◽  
Dion Alexandrou ◽  
O'Donnell Paul ◽  
...  
Keyword(s):  
Chronic Recurrent Multifocal Osteomyelitis ◽  
Whole Body ◽  
Whole Body Mri ◽  
Multifocal Osteomyelitis

scholarly journals P133 Chronic recurrent multifocal osteomyelitis (CRMO) associated with polymyositis and polyarthritis in a boy

Rheumatology ◽  
2020 ◽  
Vol 59 (Supplement_2) ◽  
Author(s):  
Devang B Pandya
Keyword(s):  
Chronic Recurrent Multifocal Osteomyelitis ◽  
Whole Body ◽  
Muscle Enzymes ◽  
Whole Body Mri ◽  
Night Pain ◽  
Severe Acne ◽  
First Choice ◽  
Paediatric Age ◽  
Multifocal Osteomyelitis ◽  
Inflammatory Bowel

Abstract Background CRMO is an autoinflammatory bone disease mainly affecting the paediatric age group. It may have overlapping features with other rheumatological diseases. I report a case of a 7-year-old boy who presented with fever, persistent limp and pain at multiple sites involving the extremities. Methods His complaint started with pain in the gluteal region with an accompanying limp. Two months later, he started having fever, pain and localised swelling around multiple sites - right knee, right ankle and left wrist associated with intermittent night pain and morning stiffness. MSK examination revealed localised peri-articular swelling and restriction of movements involving bilateral knees, ankles, hips and wrists. Lab reports showed low hemoglobin, neutrophilic leucocytosis, elevated platelets, CRP and ESR. Muscle enzymes (CPK, SGPT, SGOT, LDH), bone profile, ferritin, RF, ASO titer, ANA and ANA profile were normal. Whole body MRI (WBM) revealed multifocal bone marrow edema predominantly in metaphyseal regions involving multiple bones. Polymyositis and mild effusions were noted in bilateral hips and knees. He was put on oral naproxen, prednisolone, methotrexate and pamindronate infusion for two days. He responded dramatically and continues to remain well at two weeks' follow up. Results CRMO is mainly associated with severe acne, palmoplantar pustulosis, generalised pustular psoriasis, pyoderma gangrenosum, ankylosing spondylitis and inflammatory bowel disease. There are only 2-3 reported cases of CRMO associated myositis in adolescents to the best of my knowledge. This child will be the youngest diagnosed CRMO with polymyositis. Conclusion When any child presents with fever, recurrent or chronic night pain and/or swelling at multiple sites with moderate elevation of inflammatory markers, we should suspect CRMO and our first choice of investigation should be whole body MRI to reveal associated extra-osseous lesions. Disclosures D.B. Pandya None.

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