severe acne
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2021 ◽  
Author(s):  
Mitsumasa Kishimoto ◽  
Yoshinori Taniguchi ◽  
Shigeyoshi Tsuji ◽  
Yoko Ishihara ◽  
Gautam A Deshpande ◽  
...  

ABSTRACTS Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis (SAPHO) syndrome is a rare inflammatory osteo-articular disorder, which encompassed many diseases, including pustulotic arthro-osteitis (PAO). Bone and joint manifestations, including osteitis, synovitis and hyperostosis, are the hallmark of the SAPHO syndrome and affect a variety of regions of the body. Recent GRAPPA survey indicated that more than 80 percent of cases of SAPHO syndrome in Japan were thought to be PAO, originally proposed by Sonozaki et al. in 1981, whereas severe acne was the most commonly reported skin ailment amongst participants with SAPHO syndrome in Israel. SAPHO syndrome is a rare disease and adequate data regarding its prevalence remains unavailable, whereas prevalence of PPP was reported to be 0.12 % in Japan and 10-30% of patients with PPP had PAO. SAPHO syndrome and PAO are predominantly found in patients in the third through fifth decades of life, and a female predominance are seen in both groups. The diagnosis of SAPHO syndrome/PAO is typically made by a rheumatologist or dermatologist. Identification of a variety of the clinical, radiological, and laboratory features outlined, as well as diagnostic criteria, are used to make the diagnosis. Goals for treating patients with SAPHO syndrome/PAO seek to maximize health-related quality of life by improving skin and articular symptoms, preventing structural changes and destruction, and normalizing physical function and social participation. Finally, we review the non-pharmacological (ie: smoking cessation and controlling focal infections) and pharmacological managements including NSAIDs, bisphosphonates, cs DMARDs, bDMARDs, and other treatments for SAPHO syndrome/PAO.


Author(s):  
Katewadee Roengritthidet ◽  
Nanticha Kamanamool ◽  
Montree Udompataikul ◽  
Salinee Rojhirunsakool ◽  
Saranya Khunket ◽  
...  

The association between diet and acne has been growing in concern. Every country has its own food culture. A few studies surveyed the influence of Asian cuisine on acne. This study investigated the association between acne severity and diet/lifestyle factors in 2,467 Thai adolescents and adults. The data were collected from the validated semi-quantitative food frequency questionnaire. The prevalence of mild acne was 52%, moderate acne was 22%, and 8% severe acne in Thai adolescents and adults. No acne was found in 18% of participants. The dietary factors associated with increased acne severity were the consumption of chocolate >100 grams/weeks (aOR, 1.29; 95% CI, 1.07-1.56), oily and fried food >3 times/week (aOR, 1.84; 95% CI, 1.07-3.16) and white rice (aOR, 1.80; 95% CI, 1.24-2.63). On the contrary, the factors associated with decreased acne severity were the consumption of sugar-free tea (aOR, 0.61; 95% CI, 0.43-0.87), and vegetables (aOR, 0.74; 95% CI, 0.62-0.89).


2021 ◽  
Vol 12 ◽  
Author(s):  
Nevena Skroza ◽  
Ersilia Tolino ◽  
Veronica Balduzzi ◽  
Nicoletta Bernardini ◽  
Alessandra Mambrin ◽  
...  

This retrospective single-center study analyzes the efficacy and safety of isotretinoin for the treatment of moderate to severe acne in real-life clinical practice, particularly with regard to acne severity, isotretinoin cumulative dosage, and patients’ gender. The results suggest the opportunity of an early isotretinoin systemic treatment in patients affected by moderate acne and emphasize the importance of an appropriate dose adjustment in order to minimize adverse events.


2021 ◽  
Vol 5 (6) ◽  
pp. s70
Author(s):  
James Del Rosso ◽  
Linda Stein Gold ◽  
Stephen Tyring ◽  
William Philip Werschler ◽  
Fran Cook-Bolden ◽  
...  

N/A


2021 ◽  
pp. 20-25
Author(s):  
L. S. Kruglova ◽  
N. V. Gryazeva ◽  
E. V. Sidorenko

This article presents data on the pathogenesis of acne, the mechanisms of choosing therapy, the tactics of prescribing isotretinoin and further management of patients. Answers are given to important questions concerning the appointment of an adequate daily dose and the obligation to set of cumulative dose concerning the mandatory, the safety of drugs containing isotretinoin. In addition, the possibility of prescribing drugs based on vitamin A (retinol palmitate) in large doses in patients with acne and related adverse reactions is being discussed. The article is illustrated with three clinical examples of patients diagnosed with acne with a description of management tactics.


2021 ◽  
Author(s):  
Firas Al-Qarqaz ◽  
Khaldon Bodoor ◽  
Ala Baba ◽  
Ali Al-Yousef ◽  
Jihan Muhaidat ◽  
...  

Background: Acne is common among young individuals. People with dark skin have a higher risk for developing pigmentary complications.  Inflammation is an important factor in post-acne hyperpigmentation however other factors are also involved in developing this complication however these factors are not well studied. Objective: The aim of this study is to identify risk factors involved in post-acne hyperpigmentation. Materials and Methods: Clinical data related to acne, acne- related hyperpigmentation were collected. Data was analyzed for risk factors associated with acne pigmentation. Artificial neural network was used as predictive disease classifier for the outcome of pigmentation. Results: Majority of patients in this study (339 patients) had dark skin phototypes (3 and 4). Post- acne hyperpigmentation was seen in more than 80% of patients. Females, darker skin color, severe acne, facial sites, and excessive sunlight exposure, squeezing or scratching lesions are important risk factors for post-acne hyperpigmentation. Conclusion: Post-acne hyperpigmentation is multifactorial. Several factors implicated in PAH are modifiable by adequate patient education (lesion trauma, excessive sunlight exposure). The use of ANN was helpful in predicting appearance of post-acne hyperpigmentation based on identified risk factors.


QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Ghada Fathy Mohamed ◽  
Ahmed Abdel fattah Afify ◽  
Waleed Abdel hady Ahmed ◽  
Basant Alaa Eldin Elsayed Mohamed Elsayed Eid

Abstract Background Acne vulgaris is a multifactorial inflammatory skin disease of the pilosebaceous unit with complex pathogenesis. Calprotectin is a heterodimer of two calcium-binding proteins S100A8 and S100A9, which are members of the S100 protein family, and which play a role in various inflammatory processes, it is mainly present in the cytoplasm of neutrophils and expressed on the membrane of monocytes. Objective to assess the level of Calprotectin in blood and in tissue of AV patients and compare it with healthy controls. Beside correlate it with the degrees of severity of acne in order to further understand the role of Calprotectin in the pathogenesis of AV. Subjects and Methods This case-control study included 28 subjects who have AV, divided into four groups according to Global Acne Grading System: the first group included 7 patients with mild acne, the second group included 7 patients with moderate acne, the third group included 7 patients with severe acne, and the fourth group included 7 patients with very severe AV. In addition to a control group which included 28 apparently healthy individuals of matched age, sex and with no previous history of acne or active acne. All the patients were recruited from the outpatient clinic of Al Haud Al Marsoud hospital from September 2019 till January 2020. After taking the approval of research ethics committee (FMASU M S 22/2019) all subjects gave an informed consent to participate in this work. Results Our study showed that the increase in AV severity was not affected by the difference in gender, type of acne, nor disease duration. However, there was a significant correlation between plasma calprotectin level and AV severity. In addition to, There was a significant statistical correlation between the increase in the age of patients and the decrease in the severity of acne, which indicates that AV is more severe in younger patients than older ones. The correlation between the Plasma Calprotectin level in patients group and Tissue Calprotectin level in inflammatory lesions (papules) was non-significant. However, the correlation between the Plasma Calprotectin level in patients’ group and Tissue Calprotectin level in non-inflammatory lesions (comedones) was highly significant. Conclusion Plasma Calprotectin level showed significant relation with AV severity and presence of scar. The correlation between plasma Calprotectin level and tissue Calprotectin level in noninflammatory lesions (comedones) was highly significant.


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