scholarly journals Role of Endoscopic Ultrasound in Liver Disease: Where Do We Stand?

Diagnostics ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 2021
Author(s):  
Tajana Pavic ◽  
Ivana Mikolasevic ◽  
Dominik Kralj ◽  
Nina Blazevic ◽  
Anita Skrtic ◽  
...  
Keyword(s):  
Liver Disease ◽  
Endoscopic Ultrasound ◽  
Treatment Options ◽  
Endoscopic Examination ◽  
Focal Liver Lesions ◽  
Liver Lesions ◽  
Noninvasive Methods ◽  
Diffuse Liver Disease ◽  
Tissue Acquisition

As the burden of liver disease in the general populace steadily increases, so does the need for both advanced diagnostic and treatment options. Endoscopic ultrasound is a reliable diagnostic and therapeutic method that has an established role, foremost in pancreatobiliary pathology. This paper aims to summarize the growing role of endoscopic ultrasound in hepatology based on the search of the current literature. A number of applications of endoscopic ultrasound are reviewed, including both noninvasive methods and tissue acquisition in focal and diffuse liver disease, portal hypertension measurement, detection and management of gastric and esophageal varices, treatment of focal liver lesions and staging of pancreatobiliary malignancies, treatment of cystic and solid liver lesions, as well as liver abscess drainage. Both hepatologists and endoscopists should be aware of the evolving role of endoscopic ultrasound in liver disease. The inherent invasive nature of endoscopic examination limits its use to a targeted population identified using noninvasive methods. Endoscopic ultrasound is one the most versatile methods in gastroenterology, allowing immediate access with detection, sampling, and treatment of digestive tract pathology. Further expansion of its use in hepatology is immanent.

The role of endoscopic ultrasound elastography in differentiating focal liver lesions

2020 ◽  
Vol 32 (10) ◽  
pp. 1408-1408
Author(s):  
Apostolis Papaefthymiou ◽  
Michael Doulberis ◽  
Vassilios Papadopoulos ◽  
Fotis Tsiopoulos ◽  
Andreas Kapsoritakis ◽  
...  
Keyword(s):  
Endoscopic Ultrasound ◽  
Ultrasound Elastography ◽  
Focal Liver Lesions ◽  
Liver Lesions

scholarly journals The Role of the Histone Methyltransferase EZH2 in Liver Inflammation and Fibrosis in STAM NASH Mice

Biology ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 93 ◽  
Author(s):  
Seul Lee ◽  
Dong-Cheol Woo ◽  
Jeeheon Kang ◽  
Moonjin Ra ◽  
Ki Hyun Kim ◽  
...  
Keyword(s):  
Liver Disease ◽  
Epigenetic Modification ◽  
Treatment Options ◽  
Histone Methyltransferase ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Steatohepatitis ◽  
Promising Therapeutic Target ◽  
Alcoholic Fatty Liver Disease ◽  
Potential Therapeutics

Non-alcoholic fatty liver disease (NAFLD) is a leading form of chronic liver disease, with few biomarkers and treatment options currently available. Non-alcoholic steatohepatitis (NASH), a progressive disease of NAFLD, may lead to fibrosis, cirrhosis, and hepatocellular carcinoma. Epigenetic modification can contribute to the progression of NAFLD causing non-alcoholic steatohepatitis (NASH), in which the exact role of epigenetics remains poorly understood. To identify potential therapeutics for NASH, we tested small-molecule inhibitors of the epigenetic target histone methyltransferase EZH2, Tazemetostat (EPZ-6438), and UNC1999 in STAM NASH mice. The results demonstrate that treatment with EZH2 inhibitors decreased serum TNF-alpha in NASH. In this study, we investigated that inhibition of EZH2 reduced mRNA expression of inflammatory cytokines and fibrosis markers in NASH mice. In conclusion, these results suggest that EZH2 may present a promising therapeutic target in the treatment of NASH.

Differential diagnosis of focal liver lesions: role of spin-echo and contrast-enhanced dynamic MR imaging.

Radiology ◽  
1994 ◽  
Vol 193 (1) ◽  
pp. 59-65 ◽  
Author(s):  
Y Yamashita ◽  
Y Hatanaka ◽  
H Yamamoto ◽  
A Arakawa ◽  
T Matsukawa ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Mr Imaging ◽  
Spin Echo ◽  
Focal Liver Lesions ◽  
Liver Lesions ◽  
Dynamic Mr Imaging ◽  
Contrast Enhanced ◽  
Dynamic Mr

scholarly journals Tissue acquisition and pancreatic masses: Which needle and which acquisition technique should be used?

2020 ◽  
Vol 08 (10) ◽  
pp. E1315-E1320
Author(s):  
Benedetto Mangiavillano ◽  
Leonardo Sosa-Valencia ◽  
Pierre Deprez ◽  
Pierre Eisendrath ◽  
Carlos Robles-Medranda ◽  
...  
Keyword(s):  
Treatment Options ◽  
Fine Needle Biopsy ◽  
Needle Aspiration ◽  
Histopathological Diagnosis ◽  
Fine Needle ◽  
Oncological Treatment ◽  
Pancreatic Masses ◽  
Tissue Acquisition ◽  
Acquisition Technique

Abstract Background and study aims Pancreatic cancer represents the fourth most common cause of cancer-related deaths in Western countries and the need of a low-risk investigation to obtain an accurate histopathological diagnosis has become increasingly pressing. Endoscopic ultrasonography (EUS) with fine-needle aspiration (FNA) is the standard method for obtaining samples from pancreatic masses. In recent years, there has been an increasing need to obtain histological specimens during EUS procedures, rather than cytological ones, to guide oncological treatment options, leading to the so-call “FNB concept.” Different needles have been developed for fine-needle biopsy (FNB) in recent years, enabling acquisition of larger specimens on which to perform histological and molecular analyses. The aim of this narrative review was to assess the role of EUS-guided FNA and FNB in patients with pancreatic masses, and to identify which needle and which acquisition technique should be used to improve tissue acquisition.

scholarly journals Role of contrast enhanced ultrasound in characterization of focal liver lesions

2014 ◽  
Vol 45 (1) ◽  
pp. 7-17 ◽  
Author(s):  
Shruti Thakur ◽  
Anupam Jhobta ◽  
D.S. Dhiman ◽  
R.G. Sood ◽  
Arun Chauhan ◽  
...  
Keyword(s):  
Focal Liver Lesions ◽  
Liver Lesions ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced

scholarly journals Hepatocellular Carcinoma Is the Most Frequent Final Diagnosis of Focal Liver Lesions Identified in a Cross-Sectional Evaluation of Patients with Chronic Liver Disease in Saudi Arabia

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Adnan Agha ◽  
Manuele Furnari ◽  
Rafaat Morched Chakik ◽  
Mamdouh M. Abdulhadi Ali ◽  
Dib Alsaudi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Odds Ratio ◽  
Final Diagnosis ◽  
Liver Lesion ◽  
Focal Liver Lesions ◽  
Liver Lesions ◽  
Benign Lesions ◽  
Cross Sectional

Background. Hepatocellular carcinoma (HCC) is a frequent diagnosis in patients with chronic liver disease (CLD) and a newly identified liver lesion, although benign diseases may also be responsible for this finding. Objective. To evaluate the characteristics of focal liver lesions in a population of patients with CLD not under surveillance for HCC in the Middle East. Methods. We performed a cross-sectional study evaluating 77 patients with CLD and a focal liver lesion identified during ultrasonography. Patients’ characteristics were analyzed on the basis of the final diagnosis (HCC versus benign lesions). Results. The most frequent diagnosis was HCC (64.9%). These patients were older (median age 64 versus 55 years, P=0.003) and cirrhotics (80.0% versus 51.9%, P=0.018), with multinodular lesions (58.0% versus 29.6%, P=0.031) and portal vein thrombosis (24.0% versus 0%, P=0.001) compared to patients with benign lesions. Prevalence of elevated alpha-fetoprotein (>10 ng/mL) was similar in both groups (80.0% versus 88.9%, P=0.198). Cirrhosis (odds ratio: 3.283) and multinodularity (odds ratio: 2.898) were independently associated with HCC. Conclusions. HCC is the most common diagnosis in Middle-Eastern patients with CLD and a liver lesion identified outside HCC surveillance programs, especially in cirrhotic patients. In these patients, elevated alpha-fetoprotein does not differentiate HCC from benign lesions.

scholarly journals Diffusion-Weighted Imaging with Two Differentb-Values in Detection of Solid Focal Liver Lesions

2016 ◽  
Vol 2016 ◽  
pp. 1-9
Author(s):  
Da-wei Yang ◽  
Ke-yang Wang ◽  
Xun Yao ◽  
Hui-yi Ye ◽  
Tao Jiang ◽  
...  
Keyword(s):  
Liver Disease ◽  
Prospective Study ◽  
Diffusion Weighted Imaging ◽  
Detection Rate ◽  
Focal Liver Lesions ◽  
Liver Lesions ◽  
Diffusion Weighted ◽  
Subgroup Analyses ◽  
To Receive ◽  
Mr Sequences

One hundred and eighty-two consecutive patients with suspected liver disease were recruited to receive diffusion-weighted imaging (DWI) with two differentb-values, in comparison with T2-weighted imaging (T2WI). The detection rate of three MR sequences in solid focal liver lesions (FLLs) and subgroup analyses were performed. Our prospective study found that DWI600 was equivalent to DWI100 and T2WI for the detection of solid FLLs overall but was significantly more accurate in the detection of malignant solid FLLs and lesions larger than 10 mm.

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