scholarly journals Clinical Usefulness of Red Cell Distribution Width/Albumin Ratio to Discriminate 28-Day Mortality in Critically Ill Patients with Pneumonia Receiving Invasive Mechanical Ventilation, Compared with Lacate/Albumin Ratio: A Retrospective Cohort Study

Diagnostics ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 2344
Author(s):  
Jong Hwan Jeong ◽  
Manbong Heo ◽  
Seung Jun Lee ◽  
Yi Yeong Jeong ◽  
Jong Deog Lee ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Invasive Mechanical Ventilation ◽  
Red Cell Distribution Width ◽  
Receiver Operating Curve ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Albumin Ratio

The value of the red cell distribution width (RDW) is associated with prognosis in critically ill patients. A simplex combined index—the RDW/albumin ratio—has been proposed for the prediction of mortality, as has the lactate/albumin ratio. The aim of this study was to evaluate the clinical utility of the RDW/albumin ratio regarding 28-day mortality in critically ill patients with pneumonia. Clinical data of critically ill patients with pneumonia who were hospitalized in the medical intensive care unit from May 2018 to December 2020, and received invasive mechanical ventilation (IMV), were reviewed retrospectively. The values of RDW, lactate, and albumin measured at the time of IMV, were used for the index calculations. Of the 234 patients, the median age was 76 years, and 74.2% were male. The 28-day mortality rate was 47.3%. The median RDW/albumin ratio was significantly higher in non-survivors than survivors at 28 days (5.8 vs. 4.9, p < 0.001). A higher RDW/albumin ratio was significantly associated with increased 28-day mortality (odds ratio [OR] 1.338, 95% confidence interval [CI] 1.094–1.637, p = 0.005). The area under the receiver operating curve (AUROC) was 0.694 (95% CI: 0.630–758, p < 0.005) to discern 28-day mortality without significant difference, compared with that of the lactate/albumin ratio. Our data suggest that high RDW/albumin ratio has a similar predictability to the lactate/albumin ratio in critically ill patients with pneumonia receiving IMV.

scholarly journals Red cell distribution width and all-cause mortality in critically ill patients*

2011 ◽  
Vol 39 (8) ◽  
pp. 1913-1921 ◽  
Author(s):  
Heidi S. Bazick ◽  
Domingo Chang ◽  
Karthik Mahadevappa ◽  
Fiona K. Gibbons ◽  
Kenneth B. Christopher
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
All Cause Mortality

scholarly journals High Red Cell Distribution Width as a Biomarker of Mortality in Critically Ill Paediatric Patients

2020 ◽  
Vol 40 (3) ◽  
pp. 210-216
Author(s):  
Eva Gauchan ◽  
Sahisnuta Basnet
Keyword(s):  
Intensive Care ◽  
Critically Ill ◽  
Prognostic Indicator ◽  
Red Cell Distribution Width ◽  
Receiver Operating Curve ◽  
Critically Ill Children ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Complicated Course

Introduction: Red cell distribution width (RDW) is a frequently overlooked parameter in routine haematological reports. It is a simple and inexpensive test which has been found by many adult studies to be a prognostic indicator of mortality in intensive care units. The objective of this study was to see if high RDW could be used as a marker to predict mortality in critically ill children. Methods: This was a prospective observational study conducted in the paediatric intensive care unit (PICU) of a tertiary hospital of Western Nepal over a period of one year. Study subjects were selected by purposive sampling method. RDW at admission and relative change in RDW (ΔRDW) was compared to see if they had any role in predicting mortality in this group of children. Receiver operating curve analysis was plotted to find an optimal cut-off point to define high and low RDW and various outcome parameters were analysed. Results: Out of 131 children, there were 12 (9.1%) mortalities. Admission RDW was higher in the death group as compared to the survivor group (17 vs 14.6; p = 0.012). Similar finding was seen with ΔRDW (0.45 vs 0.00; p = 0.006). ΔRDW above the cut-off value of 0.15 was found to be associated with a generally more complicated course during hospitalisation as well as had more risk of mortality. Conclusions: Both RDW and ΔRDW above the cut-off value were found to be associated with mortality. In addition, high ΔRDW was also found to predict a more complicated course during hospitalisation.

scholarly journals Red cell distribution width as a prognostic marker in mechanically ventilated children admitted in pediatric critical care unit of tertiary care centre, India

2018 ◽  
Vol 5 (5) ◽  
pp. 1794
Author(s):  
Swati M. Gadappa ◽  
Manas Kumar Behera
Keyword(s):  
Mechanical Ventilation ◽  
Length Of Stay ◽  
Critically Ill ◽  
Red Cell Distribution Width ◽  
Critically Ill Children ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Mechanically Ventilated ◽  
Prospective Longitudinal

Background: Paediatric population is a vulnerable group necessitating standard care for medically and surgically ill children. Red cell distribution width (RDW) is a simple and low-cost measure that denotes the variability in red blood cell size. Any process that releases reticulocytes in the circulation will result in an increase in RDW. RDW may also be useful as a biomarker of disease severity and clinical outcomes in critically ill patients. Methods: Retrospective cohort study of all patients between 1month-12yrs of age, mechanically ventilated in Paediatric intensive care unit. Those patients with RDW on admission and complete data for PIM3 (Paediatric Index of Mortality 3) were included. Analyses included correlation, logistic regression analysis, and receiver operating characteristic (ROC) curves.Results: Retrospective analysis of data on 93 consecutive critically ill children admitted in PICU was done between Jan 2015- June 2016. We noted statistically significant correlation between mortality and anemia (10.24 g/dL, SD 2.26; 8.78 g/dL, SD 2.60.p = 0.009), LOS on MV (p = 0.008), RDW (p = 0.002), shock (p = 0.004) and ventilator associated Pneumonia (p = 0.024).  Mortality increased as length of stay on mechanical ventilation increased (4.13 days, SD 2.125 versus 6.94 days, SD 7.603 p = 0.008). The cut-off of 18.10 was chosen as Mean RDW. Based on AUROC, RDW is independently associated with high risk of mortality.Conclusions: RDW measured within 24 hours of PICU admission was independently associated with length of stay on mechanical ventilation and mortality in a general PICU population. We recommend the need for multicentric, prospective longitudinal studies to determine the optimum utility of RDW to enhance decision making in PICU.

scholarly journals Red Cell Distribution Width Elevation and Sepsis in Pediatric Critically Ill Patients

2018 ◽  
Vol 6 (2) ◽  
Author(s):  
Ghamartaj Khanbabaee ◽  
Seyedeh Masumeh Hashemi ◽  
Sara Salarian ◽  
Mohammad Reza Fariborzi ◽  
Azadeh Kiumarsi
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width
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