scholarly journals Raman Spectroscopy as a Process Analytical Tool for In-line and Real-time Monitoring of a Pharmaceutical Hot-melt Extrusion Process

2011 ◽  
Author(s):  
Lien Saerens ◽  
Thomas De Beer ◽  
Jean Paul Remon ◽  
Chris Vervaet
Keyword(s):  
Raman Spectroscopy ◽  
Real Time ◽  
Hot Melt Extrusion ◽  
Extrusion Process ◽  
Analytical Tool ◽  
Real Time Monitoring ◽  
Melt Extrusion ◽  
Hot Melt

Global approach for the validation of an in-line Raman spectroscopic method to determine the API content in real-time during a hot-melt extrusion process

Talanta ◽  
2017 ◽  
Vol 171 ◽  
pp. 45-52 ◽  
Author(s):  
L. Netchacovitch ◽  
J. Thiry ◽  
C. De Bleye ◽  
E. Dumont ◽  
J. Cailletaud ◽  
...  
Keyword(s):  
Real Time ◽  
Spectroscopic Method ◽  
Hot Melt Extrusion ◽  
Extrusion Process ◽  
Global Approach ◽  
Melt Extrusion ◽  
Raman Spectroscopic ◽  
Hot Melt

scholarly journals Application of FT-NIR Analysis for In-line and Real-Time Monitoring of Pharmaceutical Hot Melt Extrusion: a Technical Note

2018 ◽  
Vol 19 (8) ◽  
pp. 3425-3429 ◽  
Author(s):  
Anh Q. Vo ◽  
Herman He ◽  
Jiaxiang Zhang ◽  
Scott Martin ◽  
Rui Chen ◽  
...  
Keyword(s):  
Real Time ◽  
Hot Melt Extrusion ◽  
Technical Note ◽  
Real Time Monitoring ◽  
Melt Extrusion ◽  
Hot Melt

scholarly journals Development of Porous Polyurethane Implants Manufactured via Hot-Melt Extrusion

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2950
Author(s):  
Ioannis Koutsamanis ◽  
Martin Spoerk ◽  
Florian Arbeiter ◽  
Simone Eder ◽  
Eva Roblegg
Keyword(s):  
Material Selection ◽  
Hot Melt Extrusion ◽  
Extrusion Process ◽  
Controlled Delivery ◽  
Application Site ◽  
Melt Extrusion ◽  
Average Pore ◽  
Porous Carrier ◽  
Good Patient Compliance ◽  
Hot Melt

Implantable drug delivery systems (IDDSs) offer good patient compliance and allow the controlled delivery of drugs over prolonged times. However, their application is limited due to the scarce material selection and the limited technological possibilities to achieve extended drug release. Porous structures are an alternative strategy that can overcome these shortcomings. The present work focuses on the development of porous IDDS based on hydrophilic (HPL) and hydrophobic (HPB) polyurethanes and chemical pore formers (PFs) manufactured by hot-melt extrusion. Different PF types and concentrations were investigated to gain a sound understanding in terms of extrudate density, porosity, compressive behavior, pore morphology and liquid uptake. Based on the rheological analyses, a stable extrusion process guaranteed porosities of up to 40% using NaHCO3 as PF. The average pore diameter was between 140 and 600 µm and was indirectly proportional to the concentration of PF. The liquid uptake of HPB was determined by the open pores, while for HPL both open and closed pores influenced the uptake. In summary, through the rational selection of the polymer type, the PF type and concentration, porous carrier systems can be produced continuously via extrusion, whose properties can be adapted to the respective application site.

scholarly journals Hot-melt extrusion process impact on polymer choice of glyburide solid dispersions: The effect of wettability and dissolution

2019 ◽  
Vol 559 ◽  
pp. 245-254 ◽  
Author(s):  
Maen Alshafiee ◽  
Mohammad K. Aljammal ◽  
Daniel Markl ◽  
Adam Ward ◽  
Karl Walton ◽  
...  
Keyword(s):  
Solid Dispersions ◽  
Hot Melt Extrusion ◽  
Extrusion Process ◽  
Melt Extrusion ◽  
Hot Melt
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