Visualization and Process Understanding of Material Behavior in the Extrusion Barrel during a Hot-Melt Extrusion Process Using Raman Spectroscopy

2013 ◽  
Vol 85 (11) ◽  
pp. 5420-5429 ◽  
Author(s):  
Lien Saerens ◽  
Chris Vervaet ◽  
Jean-Paul Remon ◽  
Thomas De Beer
Keyword(s):  
Raman Spectroscopy ◽  
Hot Melt Extrusion ◽  
Extrusion Process ◽  
Material Behavior ◽  
Melt Extrusion ◽  
Process Understanding ◽  
Hot Melt

Development and Performance of a Highly Sensitive Model Formulation Based on Torasemide to Enhance Hot-Melt Extrusion Process Understanding and Process Development

2018 ◽  
Vol 19 (4) ◽  
pp. 1592-1605 ◽  
Author(s):  
Rachel C. Evans ◽  
Samuel O. Kyeremateng ◽  
Lutz Asmus ◽  
Matthias Degenhardt ◽  
Joerg Rosenberg ◽  
...  
Keyword(s):  
Process Development ◽  
Hot Melt Extrusion ◽  
Extrusion Process ◽  
Model Formulation ◽  
Melt Extrusion ◽  
Process Understanding ◽  
Highly Sensitive ◽  
And Performance ◽  
Hot Melt

Global approach for the validation of an in-line Raman spectroscopic method to determine the API content in real-time during a hot-melt extrusion process

Talanta ◽  
2017 ◽  
Vol 171 ◽  
pp. 45-52 ◽  
Author(s):  
L. Netchacovitch ◽  
J. Thiry ◽  
C. De Bleye ◽  
E. Dumont ◽  
J. Cailletaud ◽  
...  
Keyword(s):  
Real Time ◽  
Spectroscopic Method ◽  
Hot Melt Extrusion ◽  
Extrusion Process ◽  
Global Approach ◽  
Melt Extrusion ◽  
Raman Spectroscopic ◽  
Hot Melt

scholarly journals Development of Porous Polyurethane Implants Manufactured via Hot-Melt Extrusion

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2950
Author(s):  
Ioannis Koutsamanis ◽  
Martin Spoerk ◽  
Florian Arbeiter ◽  
Simone Eder ◽  
Eva Roblegg
Keyword(s):  
Material Selection ◽  
Hot Melt Extrusion ◽  
Extrusion Process ◽  
Controlled Delivery ◽  
Application Site ◽  
Melt Extrusion ◽  
Average Pore ◽  
Porous Carrier ◽  
Good Patient Compliance ◽  
Hot Melt

Implantable drug delivery systems (IDDSs) offer good patient compliance and allow the controlled delivery of drugs over prolonged times. However, their application is limited due to the scarce material selection and the limited technological possibilities to achieve extended drug release. Porous structures are an alternative strategy that can overcome these shortcomings. The present work focuses on the development of porous IDDS based on hydrophilic (HPL) and hydrophobic (HPB) polyurethanes and chemical pore formers (PFs) manufactured by hot-melt extrusion. Different PF types and concentrations were investigated to gain a sound understanding in terms of extrudate density, porosity, compressive behavior, pore morphology and liquid uptake. Based on the rheological analyses, a stable extrusion process guaranteed porosities of up to 40% using NaHCO3 as PF. The average pore diameter was between 140 and 600 µm and was indirectly proportional to the concentration of PF. The liquid uptake of HPB was determined by the open pores, while for HPL both open and closed pores influenced the uptake. In summary, through the rational selection of the polymer type, the PF type and concentration, porous carrier systems can be produced continuously via extrusion, whose properties can be adapted to the respective application site.

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