Elucidation and visualization of solid-state transformation and mixing in a pharmaceutical mini hot melt extrusion process using in-line Raman spectroscopy

2017 ◽  
Vol 517 (1-2) ◽  
pp. 119-127 ◽  
Author(s):  
Jeroen Van Renterghem ◽  
Ashish Kumar ◽  
Chris Vervaet ◽  
Jean Paul Remon ◽  
Ingmar Nopens ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Solid State ◽  
Hot Melt Extrusion ◽  
Extrusion Process ◽  
Melt Extrusion ◽  
State Transformation ◽  
Solid State Transformation ◽  
Hot Melt

scholarly journals Development of Porous Polyurethane Implants Manufactured via Hot-Melt Extrusion

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2950
Author(s):  
Ioannis Koutsamanis ◽  
Martin Spoerk ◽  
Florian Arbeiter ◽  
Simone Eder ◽  
Eva Roblegg
Keyword(s):  
Material Selection ◽  
Hot Melt Extrusion ◽  
Extrusion Process ◽  
Controlled Delivery ◽  
Application Site ◽  
Melt Extrusion ◽  
Average Pore ◽  
Porous Carrier ◽  
Good Patient Compliance ◽  
Hot Melt

Implantable drug delivery systems (IDDSs) offer good patient compliance and allow the controlled delivery of drugs over prolonged times. However, their application is limited due to the scarce material selection and the limited technological possibilities to achieve extended drug release. Porous structures are an alternative strategy that can overcome these shortcomings. The present work focuses on the development of porous IDDS based on hydrophilic (HPL) and hydrophobic (HPB) polyurethanes and chemical pore formers (PFs) manufactured by hot-melt extrusion. Different PF types and concentrations were investigated to gain a sound understanding in terms of extrudate density, porosity, compressive behavior, pore morphology and liquid uptake. Based on the rheological analyses, a stable extrusion process guaranteed porosities of up to 40% using NaHCO3 as PF. The average pore diameter was between 140 and 600 µm and was indirectly proportional to the concentration of PF. The liquid uptake of HPB was determined by the open pores, while for HPL both open and closed pores influenced the uptake. In summary, through the rational selection of the polymer type, the PF type and concentration, porous carrier systems can be produced continuously via extrusion, whose properties can be adapted to the respective application site.

Sign in / Sign up

Export Citation Format

Share Document