scholarly journals Utility and Cutoff Value of Hair Nicotine as a Biomarker of Long-Term Tobacco Smoke Exposure, Compared to Salivary Cotinine

2014 ◽  
Vol 11 (8) ◽  
pp. 8368-8382 ◽  
Author(s):  
Sungroul Kim ◽  
Benjamin Apelberg ◽  
Erika Avila-Tang ◽  
Lisa Hepp ◽  
Dongmin Yun ◽  
...  
2007 ◽  
Vol 26 (6) ◽  
pp. 535-544 ◽  
Author(s):  
E. Köhler ◽  
S. Avenarius ◽  
A. Rabsilber ◽  
C. Gerloff ◽  
G. Jorch

Meconium samples collected from 115 neonates were analysed for nicotine, cotinine and trans -3-hydroxycotinine (OH-cotinine) by means of high-performance liquid chromatography (HPLC) to identify prenatal smoke exposure. The self-reported maternal smoking status during pregnancy was determined by means of a questionnaire and verified by measurements in urine prior to childbirth. The total sum of nicotine and its metabolites (Sumtot) of the first passed meconium samples was 1560 ± 1024 pmol/g in newborns of smoking mothers. Smoking of less than five cigarettes was clearly detected. Sumtot remained constant in all meconium samples passed by a neonate in succession. However, the proportion of nicotine decreased with the time of passage after birth and the OH-cotinine proportion increased, whereas cotinine hardly changed. Nicotine or its metabolites were not detectable in meconium (detection limit < 20 pmol/g), when the mothers were only exposed to environmental tobacco smoke (ETS) using the HPLC method. The hypothesis that the content of nicotine metabolites in meconium reflects long-term smoke exposure could not be confirmed in newborns whose mothers had quit smoking during the latter half of pregnancy. Determining Sumtot enables the intensity of continuous smoking during pregnancy to be estimated in all meconium samples passed by a newborn. Human & Experimental Toxicology (2007) 26: 535—544


1987 ◽  
Vol 136 (2) ◽  
pp. 305-309 ◽  
Author(s):  
David B. Coultas ◽  
Cheryl A. Howard ◽  
Glenn T. Peake ◽  
Betty J. Skipper ◽  
Jonathan M. Samet

2020 ◽  
Vol 58 (1) ◽  
pp. 21-30 ◽  
Author(s):  
Bradley N. Collins ◽  
Uma S. Nair ◽  
Katie I. DiSantis ◽  
Melbourne F. Hovell ◽  
Samantha M. Davis ◽  
...  

BMJ Open ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. e049547
Author(s):  
Matthew Robson ◽  
Joseph Lord ◽  
Tim Doran

ObjectiveTo estimate the equity impacts of the 2007 smoking ban in England, for both smokers and non-smokers.DesignDoubly robust regression discontinuity analysis of salivary cotinine levels. Conditional average treatment effects were used to estimate differential impacts of the ban by socioeconomic deprivation (based on the Index of Multiple Deprivation). Distributional impacts were further assessed using conditional quantile treatment effects and inequality treatment effects.SettingIn 2007, England introduced a ban on smoking in public places. This had little impact on tobacco consumption by smokers but was associated with decreases in environmental tobacco smoke exposure for non-smokers. However, the impact of the ban on socioeconomic inequalities in exposure is unclear.Participants766 smokers and 2952 non-smokers responding to the Health Survey for England in 2007.Outcome measureLevels of salivary cotinine.ResultsBefore the ban, socioeconomic deprivation was associated with higher cotinine levels for non-smokers but not for smokers. The ban caused a significant reduction in average cotinine levels for non-smokers (p=0.043) but had no effect for smokers (p=0.817). Reductions for non-smokers were greater for more deprived groups with higher levels of exposure, and there was a significant reduction in socioeconomic-related inequality in cotinine. Across the whole population (both smokers and non-smokers), there was no significant increase in the concentration of cotinine levels among the socioeconomically deprived.ConclusionThe 2007 ban on smoking in public places had little impact on smokers, but was, as intended, associated with reductions in both (1) average levels of environmental tobacco smoke exposure and (2) deprivation-related inequality in exposure among non-smokers.


2020 ◽  
Vol 17 (10) ◽  
pp. 1835-1847
Author(s):  
Ahmet Yardimci ◽  
Ramazan Fazil Akkoc ◽  
Ahmet Tektemur ◽  
Nazife Ulker ◽  
Nalan Kaya Tektemur ◽  
...  

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