scholarly journals Bilateral Nephroblastoma with Dilated Cardiomyopathy as an Indication for Off-Protocol Treatment: A Case Report

Author(s):  
Patrycja Sosnowska-Sienkiewicz ◽  
Ewelina Gowin ◽  
Katarzyna Jończyk-Potoczna ◽  
Przemysław Mańkowski ◽  
Jan Godziński ◽  
...  

Patients with a Wilms tumor are often admitted to the hospital accidentally, with an abdominal mass causing asymmetry of the abdominal wall. Hypertension accompanying a Wilms tumor occurs in about 10–27% of children, but cardiomyopathy associated with a Wilms tumor is very rarely described. This publication presents a case of a 9-month-old girl with a bilateral Wilms tumor accompanied by dilated cardiomyopathy since her initial cancer diagnosis, as well as her off-protocol treatment. The severe condition of the child forced the application of off-protocol treatment, i.e., accelerated resection of a larger tumor, which enabled the improvement of heart performance and made subsequent therapy possible. In the course of the presented treatment, a gradual normalization of cardiac ventricular function and contractility was observed. In conclusion, a massive abdominal tumor associated with abdominal compartment syndrome compromised the functioning of the cardiovascular system in the young child. Therefore, earlier removal of Wilms tumors in patients with heart failure should be considered. This may result in the improvement of cardiovascular function and the possibility of further therapy.

2002 ◽  
Vol 39 (3) ◽  
pp. 376-379 ◽  
Author(s):  
Chung-Chih Yu ◽  
Fen-Hwa Wong ◽  
Lun-Jou Lo ◽  
Yu-Ray Chen

Objective: The association of cleft lip/palate (CLP) with other anomalies is not uncommon, but its association with Wilms tumor (WT) is very rare, especially in a familial pattern. In this report, we present a family in which six members in two generations were affected with CLP, WT, or both. Patients and Results: A male patient presented with right complete CLP. He had a family history of facial cleft and abdominal tumor. Lip repair was performed at 3 months of age. An abdominal mass was noticed at 12 months of age, which proved to be WT. Surgical excision of the tumor and chemotherapy were conducted. He subsequently underwent palate repair. His father had an unrepaired microform cleft lip. Three of his aunts were known to have similar problems: one had both facial cleft and WT, one had WT only, and the other had facial cleft only. One of his cousins also was affected with WT. Conclusions: This is a unique family affected with a rare association of CLP and WT. Pedigree study revealed an autosomal dominant hereditary pattern.


2013 ◽  
Vol 30 (3) ◽  
pp. 318-320 ◽  
Author(s):  
Murat Alkan ◽  
Cemal Parlakgumus ◽  
Serdar Hilmi Iskit ◽  
Recep Tuncer ◽  
Hasan Okur ◽  
...  

Urology ◽  
2021 ◽  
Author(s):  
Deguang Meng ◽  
Xiaofeng Chang ◽  
Qinghua Ren ◽  
Jiatong Xu ◽  
Huanmin Wang

1987 ◽  
Vol 138 (4 Part 2) ◽  
pp. 968-973 ◽  
Author(s):  
M.L. Blute ◽  
P.P. Kelalis ◽  
K.P. Offord ◽  
N. Breslow ◽  
J.B. Beckwith ◽  
...  

2016 ◽  
Vol 12 (6) ◽  
pp. 5075-5079
Author(s):  
Zechen Yan ◽  
Qingjun Meng ◽  
Jinjian Yang ◽  
Junjie Zhang ◽  
Wei Zhao ◽  
...  

Author(s):  
Arnold C. Paulino ◽  
Judith Wilimas ◽  
Neyssa Marina ◽  
Dana Jones ◽  
Mahesh Kumar ◽  
...  

PEDIATRICS ◽  
1982 ◽  
Vol 70 (1) ◽  
pp. 135-136
Author(s):  
Deborah Tolchin ◽  
Mordecai Koenigsberg ◽  
Maria Santorineou

There have been many reports of the association between hemihypertrophy and intraabdominal masses, including Wilms' tumor, hepatoma, and adrenal cortical neoplasias.1 The present report describes a patient with segmental hemihypertrophy, multiple ovarian cysts, and bilateral Wilms' tumor and suggests a screening regimen for patients with hemihypertrophy. CASE REPORT The patient was a 9 lb 14 oz product of a term pregnancy, who was well until a mass filling the entire right side of the abdomen was discovered on routine examination at 4 months of age. Intravenous pyelogram (IVP) confirmed a large prerenal mass which on ultrasound was felt to be an ovarian cyst.


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