scholarly journals Symptom Profiles, Health-Related Quality of Life, and Clinical Blood Markers among Korean Community-Dwelling Older Adults Living with Chronic Conditions

Author(s):  
Jongmin Park ◽  
Nada Lukkahatai ◽  
Nancy Perrin ◽  
Yoonju Kim ◽  
Leorey N. Saligan ◽  
...  

Older adults suffer from multiple symptoms, which negatively affects their health-related quality of life. The single-symptom management approach has been less than effective. The data of 2362 Korean community-dwelling older adults aged 70 and above were analyzed in the Korean Frailty and Aging Cohort Study (KFACS) study. A cluster analysis, correlation analysis, and logistic regression were used to analyze the data. We found three symptom clusters: high symptom burden (HSB, n = 1032); pain and fatigue group (PAF, n = 566); and the sleep deprivation group (SDP, n = 764). Participants in the HSB group are more likely to be of old age (OR = 1.1), be female (OR = 2.4), live in a rural area (OR = 1.4), have low physical activity (OR = 0.9), and have multiple chronic conditions (OR = 1.5). The clinical blood markers analysis showed a negative relationship among the physical health, free T4 (r = −0.083, p < 0.01) and insulin (r = −0.084, p < 0.01). The sex-specific blood markers analysis showed differences among three clusters. While free testosterone (male: r = 0.124, female: r = 0.110, p < 0.05) and dehydroepiandrosterone (DHEA) (male: r = 0.352 and female: r = 0.134, p < 0.05) were associated with physical health in the HSB group, only free testosterone was associated with mental health (male: r = −0.093, and female: r = −0.116, p < 0.05) in the SDP group. These findings suggest the potential role of the patient’s sex and sex hormones in symptoms of Korean community-dwelling older adults. Understanding the symptom profiles and impact of biopsychosocial factors may enhance precision symptom management.

Drugs & Aging ◽  
2017 ◽  
Vol 34 (10) ◽  
pp. 785-792 ◽  
Author(s):  
Benoit Cossette ◽  
Maimouna Bagna ◽  
Modou Sene ◽  
Caroline Sirois ◽  
Gabrielle P. Lefebvre ◽  
...  

2015 ◽  
Vol 25 (7) ◽  
pp. 1735-1742 ◽  
Author(s):  
Maria Augusta Bessa Rebelo ◽  
Evangeline Maria Cardoso ◽  
Peter G. Robinson ◽  
Mario Vianna Vettore

PLoS ONE ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. e0155171 ◽  
Author(s):  
Raúl F Pérez-Tasigchana ◽  
Luz M. León-Muñoz ◽  
Esther López-García ◽  
José R. Banegas ◽  
Fernando Rodríguez-Artalejo ◽  
...  

2019 ◽  
Vol 8 (11) ◽  
pp. 1810 ◽  
Author(s):  
Encarnación Blanco-Reina ◽  
Jenifer Valdellós ◽  
Ricardo Ocaña-Riola ◽  
María Rosa García-Merino ◽  
Lorena Aguilar-Cano ◽  
...  

The main aim of this study was to determine the association of various clinical, functional and pharmacological factors with the physical (PCS) and mental (MCS) summary components of the health-related quality of life (HRQoL) of community-dwelling older adults. Design: Cross-sectional study. Patients and setting: Sample of 573 persons aged over 65 years, recruited at 12 primary healthcare centres in Málaga, Spain. Sociodemographic, clinical, functional, and comprehensive drug therapy data were collected. The main outcome was HRQoL assessed on the basis of the SF-12 questionnaire. A multinomial logistic regression model was constructed to study the relationship between independent variables and the HRQoL variable, divided into intervals. The average self-perceived HRQoL score was 43.2 (± 11.02) for the PCS and 48.5 (± 11.04) for the MCS. The factors associated with a poorer PCS were dependence for the instrumental activities of daily living (IADL), higher body mass index (BMI), number of medications, and presence of osteoarticular pathology. Female gender and the presence of a psychopathological disorder were associated with worse scores for the MCS. The condition that was most strongly associated with a poorer HRQoL (in both components, PCS and MCS) was that of frailty (odds ratio (OR) = 37.42, 95% confidence interval (CI) = 8.96–156.22, and OR = 20.95, 95% CI = 7.55–58.17, respectively). It is important to identify the determinant factors of a diminished HRQoL, especially if they are preventable or modifiable.


2014 ◽  
Vol 37 (2) ◽  
pp. 83-91 ◽  
Author(s):  
Cecelia Sartor-Glittenberg ◽  
Sara Lehmann ◽  
Mari Okada ◽  
Danielle Rosen ◽  
Kathryn Brewer ◽  
...  

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